The Caudwell Xtreme Everest (CXE) expedition in the spring of 2007 was a large field-study investigating adaptive responses to hypoxia, and was supported by a grant from the Intensive Care Foundation. This article sets out to explain why the CXE team went to Everest, what they hope to learn, and discusses some of the key studies.
GrocottMP. Human physiology in extreme environments: lessons from life at the limits?Postgrad Med J2008;84: 2–3.
5.
GrocottMMontgomeryHVercueilA. High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Crit Care2007;11: 203.
6.
MarshallRPWebbSBellinganGJAngiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med2002;166: 646–50.
7.
HardingDBainesPBBrullDSeverity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism. Am J Respir Crit Care Med2002;165: 1103–06.
8.
MontgomeryHEMarshallRHemingwayHHuman gene for physical performance. Nature1998;393: 221–22.
SingerMDe SantisVVitaleDJeffcoateW. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet2004;364: 545–48.
12.
PB-PG-0906-11426. A randomised controlled trial of the utility of Cardiopulmonary Exercise Testing for preoperative risk stratification to guide perioperative care and thereby reduce postoperative morbidity. National Institute for Health Research, Research for Patient Benefit Program (Competition 2) www.nihr-ccf.org.uk/site/conimissionedprojects/default.cfm?subcat=viewprogrammes (accessed 16 February 2007).