Bone metastasis is a common problem affecting a significant proportion of patients with metastatic cancer. Bone metastasis can present in a number of ways and the patients may need surgical stabilisation of their lesions. There are many important considerations in the care of these patients that need to be borne in mind including their increased anesthetic risks and potential risk of complications. There are continuous developments in the prevention, diagnosis and treatment with advances in imaging, orthopaedic technique and medication, particularly radiopharmaceuticals and cytotoxic, endocrine treatments with newer treatments based around the tumour cell-osteoclast interaction. Having a better understanding of these considerations and developments is important in allowing the optimisation of the care of the patient with bone metastasis.
AokiJ, InoueT, TomiyoshiK2001Nuclear imaging of bone tumors: FDG-PETSemin Musculoskelet Radiol5(2) 183–7
2.
BibboC, PatelD, BeneveniaJ1999Perioperative considerations in patients with metastatic diseaseOrthopaedic Clinics of North America31(4) 577–95
3.
Breast Specialty Group of the British Association of Surgical Oncology (BASO)1999The management of metastatic bone disease in the UKEuropean Journal of Surgical Oncology253–23
ColemanRE1997Skeletal complications of malignancyCancer80(S)1588–94
9.
CookAM, LauTN, TomlinsonMJ, VaidyaM, WakeleyCJ, GoddardP1998Magnetic resonance imaging of the whole spine in suspected malignant spinal cord compression: impact on managementClinical Oncology10(1) 39–43
10.
CookGJ, FogelmanI2000The role of positron emission tomography in the management of bone metastasesCancer88(S12) 2927–33
11.
DaltonJA, YoungbloodR2000Clinical application of the World Health Organization analgesic ladderJournal of Intravenous Nursing23(2) 118–24
12.
DielIJ, JaschkeA, SolomayerEF2008Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow—a long-term follow-upAnnals of Oncology19(12) 2007–11
13.
FleischH1991Bisphosphonates Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone diseaseDrugs42(6) 919–44
14.
FleischH2002Development of bisphosphonatesBreast Cancer Research4(1) 30–4
15.
HabermannET, LopezRA1989Metastatic disease of bone and treatment of pathological fracturesOrthopaedic Clinics of North America20(3) 469–86
16.
HaynesAB, WeiserTG, BerryWR2009A surgical safety checklist to reduce morbidity and mortality in a global populationNew England Journal of Medicine360491–99
17.
HeldJL, PeahotaA1993Nursing care of the patient with spinal cord compressionOncology Nursing Forum20(10) 1507–16
18.
HusbandDJ1998Malignant spinal cord compression: prospective study of delays in referral and treatmentBritish Medical Journal317(7150) 18–21
19.
JanjanNA1997Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticalsCancer80(S8) 1628–45
20.
KardamakisD, VassiliouV, ChowE2009Bone metastases: A translational and clinical approachCancer Metastasis - Biology and Treatment12, DOI: 10.1007/978-1-4020-9819-2
21.
KohnoN, AogiK, MinamiH, NakamuraS, AsagaT, Yuichi2005Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trialJournal of Clinical Oncology23(15) 3314–21
22.
LevackP, GrahamJ, CollieD2001A prospective audit of the diagnosis, management and outcome of malignant spinal cord compressionClinical Resource and Audit Group (CRAG)97/08
23.
LiptonA2004Pathophysiology of bone metastases: how this knowledge may lead to therapeutic interventionSupport Oncology2205–20
24.
LoblawDA, LaperriereNJ, MackillopWJ2003A population-based study of malignant spinal cord compression in OntarioClinical Oncology (Royal College of Radiologists)15(4) 211–7
25.
MajorPP, CookRJ2004Clinical endpoints for assessing bisphosphonate efficacy in the prevention of skeletal complications of bone metastasesEuropean UrologyS334–39
26.
MirelsH1989Metastatic disease in long bones: A proposed scoring system for diagnosing impending pathologic fractureClinical Orthopaedic Related Research249256
27.
MerrickMV, BealesJS, GarvieN, LeonardRC1992Evaluation and skeletal metastasesBritish Journal of Radiology65(777) 803–6
28.
MoosRV, StrasserF, GillessenS, ZauggK2008Metastatic bone pain: treatment options with an emphasis on bisphosphonatesSupport Care Cancer161105–15
29.
MundyGR2002Metastasis to bone: causes, consequences and therapeutic opportunitiesNature Reviews Cancer2584–93
30.
NiermanE, ZakrzewskiK1999Recognition and management of preoperative riskRheumatic Disease Clinics of North America25585–622
31.
PehWC2000Screening for bone metastasesAmerican Journal of Orthopaedics2(5) 405
32.
RosenLS, GordonD, KaminskiM2003Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trialJournal of Clinical Oncology21(16) 3150–57
33.
Royal College of Anaesthetists2004Guidelines for the Provision of Anaesthetic ServicesLondon, RCoA Available from: www.rcoa.ac.uk/docs/GPAS.pdf [Accessed November 2011]
34.
Royal College of Surgeons2003Preoperative tests - the use of routine preoperative tests for elective surgery. Appendices, guidelines and informationLondon, RCS Available from: http://www.rcseng.ac.uk/publications/docs/preop_test.html/ [Accessed October 2011]
35.
RubinsJR1983The role of myelofibrosis in malignant myelosclerosisCancer51308–11
36.
SaartoT, BlomqvistC, VirkkunenP1999No reduction of bone metastases with adjuvant clodronate treatment in node-positive breast cancer patientsProceedings of American Society Clinical Oncology18128a
37.
SalmonJM, KilpatrickSE2000Pathology of skeletal metastasesOrthopaedic Clinics of North America31(4) 537–44 vii–viii
38.
SmallEJ, SmithMR, SeamanJJ, PetroneS, KowalskiMO2003Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancerJournal of Clinical Oncology21(23) 4277–84
39.
TraillZC, TalbotD, GoldingS, GleesonFV1999Magnetic resonance imaging versus radionuclide scintigraphy in screening for bone metastasesClinical Radiology54(7) 448–51
40.
van der PluijmG, LowikC, PapapoulosS2000Tumour progression and angiogenesis in bone metastases from breast cancer: new approaches to an old problemCancer Treat Reviews2611–27
41.
WeberKL2010Evaluation of the adult patient (aged >40 years) with a destructive bone lesionJournal of American Academy of Orthopaedic Surgeons18(3) 169–79
42.
YonedaT, MichigamiT, YiB1999Use of bisphosphonates for the treatment of bone metastasis in experimental animal modelsCancer Treat Reviews25293–99
