Cardiac surgery is one of the largest users of blood and blood products – currently estimated at 15% of UK blood stocks. While the blood supply could be considered to be the safest it has ever been, there are well recognised risks associated with the transfusion of red cells and blood products. It is appropriate that attempts should be made to decrease and optimise the transfusion of blood and blood products.
AndersonL, QuasimI, SoutarR, StevenM, MacfieA, KorteW2006An audit of red cell and blood product use after institution of thromboelastometry in a cardiac intensive care unitTransfusion Medicine1631–39
2.
CladellasM, BrugueraJ, CominJ2006Is pre-operative anaemia a risk marker for in-hospital mortality and morbidity after valve replacementEuropean Heart Journal271093–1099
3.
EngorenMC, HabibRH, ZachariasA, SchwannTA, RiordanCJ, DurhamSJ2002Effect of blood transfusion on long-term survival after cardiac operationAnnals of Thoracic Surgery741180–1186
4.
FerrarisV, FerrarisS, SahaS2007Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists clinical practice guidelinesAnnals of Thoracic Surgery83S27–86
5.
FergussonDA, HebertPC, MazerCD2008A comparison of aprotinin and lysine analogues in high-risk cardiac surgeryNew England Journal of Medicine3582319–2331
6.
GillR, HerbertsonM, VuylstekeA2009Safety and efficacy of recombinant activated factor VII: a randomized placebo-controlled trial in the setting of bleeding after cardiac surgeryCirculation12021–27
7.
KlausM, WiesnerG, BreuerT, LangeR, TassaniP2008The risks of aprotinin and tranexamic acid in cardiac surgery; a one-year follow-up of 1188 consecutive patientsAnesthesia and Analgesia107(6) 1783–1790
8.
KochCG, LiL, DuncanAI2006Morbidity and mortality associated with red blood cell and blood-component transfusion in isolated coronary artery bypass graftingCritical Care Medicine341608–1616
9.
LaupacisA, FergussonD for the International Study of Perioperative Transfusion (ISPOT) investigators 1997Drugs to minimize perioperative blood loss in cardiac surgery; meta-analyses using perioperative blood transfusion as the outcomeAnesthesia and Analgesia851258–1267
10.
LeviM, CromheeckeME, de JongeE1999Pharmacological strategies to decrease excessive blood loss in cardiac surgery; a meta-analysis of clinically relevant endpointsThe Lancet3541940–1947
11.
ManganoDT, TudorIC, DietzelC2006The risk associated with aprotinin in cardiac surgeryNew England Journal of Medicine354353–365
12.
NatansonC, KernSJ, LurieP, BanksSM, WolfeSM2008Cell-free Hemoglobin-based blood substitutes and risk of myocardial infarction and deathJournal of the American Medical Association299(19) 2304–2312
13.
NuttallGA, OliverWC, SantrachP2001Efficacy of a simple intraoperative transfusion algorithm for non-erythrocyte component utilization after cardiopulmonary bypassAnesthesiology94773–381
14.
PedenAH, HeadMW, RitchieDL, BellJE, IronsideJW2004Preclinical vCJD after blood transfusion in a codon 129 heterozygous patientThe Lancet364(9633) 527–529
15.
Quality Improvement Scotland Health Technology Assessment2008The clinical and cost-effectiveness of thromboelastography/thromboelastometry Available from: http://www.nhshealthquality.org/nhsqis/4203.html (Accessed October 2010)
16.
Rahe-MeyerN, WinterhalterM, BodenA2009Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometryActa Anaestheiologica Scandinavica53168–175
Shore-LessersonL, ManspeizerH, DePerioM, FrancisS, Veli-CantosF, ErginMA1999Thromboelastography-guided transfusion algorithm reduces transfusion in complex cardiac surgeryAnesthesia and Analgesia88312–319
19.
SowadeO, WarnkeH, ScigallaP1997Avoidance of allogeneic blood transfusions by treatment with epoetin beta (recombinant human erythropoietin) in patients undergoing open-heart surgeryBlood89(2) 411–418
20.
SpaldingGJ, HartrumpfM, SierigT2007Cost reduction of perioperative coagulation management in cardiac surgery: value of ‘bedside’ thromboelastography (ROTEM)European Journal of Cardiothoracic Surgery311052–1057
21.
SpiessB, LeyC, BodyS1998Hematocrit value on intensive care unit entry influences the frequency of Q-wave myocardial infarction after coronary artery bypass graftingJournal of Thoracic and Cardiovascular Surgery116(3) 460–467
22.
StevenM, QuasimI, SoutarR, AndersonL2004Pre and postoperative iron status in patients presenting for cardiac surgeryEuropean Journal of Anaesthesiology21(suppl S33 p 1–43)
23.
StoverEP, SiegelLC, ParksR1998Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines; a 24-institution study. Institutions of the multicentre study for perioperative ischemia research groupAnesthesiology88327–333
24.
SurgenorSD, KramerRS, OlmsteadEM2009The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgeryAnesthesia and Analgesia108(6) 1741–1746
25.
Van der LindenP, SakrP2005Acute normovolaemic haemodilution in cardiac surgeryTransfusion Alternatives in Transfusion Medicine7(1) 11–19
26.
WangG, BainbridgeD, MartinJ, ChengD2009The efficacy of an intraoperative cell saver during cardiac surgery; a meta-analysis of randomized trialsAnesthesia and Analgesia109320–330
27.
WeiskopfRB, VieleMK, FeinerJ1998Human cardiovascular and metabolic response to acute severe isovolemic anemiaJournal of the American Medical Association279217–221