Synthesis of the Pseudoguaianolide and Guaianolide Skeleton by Cleavage of the Ether Bridge of 8-Oxabicyclo[3.2.1]octan-3-one Derivatives †

Abstract

The synthesis of three new polysubstituted cycloheptenones by cleavage of the ether bridge of 8-oxabicyclo[3.2.1]octan-3-one derivatives is described, together with the application of this methodology in the construction of the guaianolide and pseudoguaianolide skeleton.