Phosphorylation of phenols with diethyl chlorophosphonate on the surface of magnesia is an easy, rapid, safe and high-yielding reaction.
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All products gave satisfactory spectral data in accord with the assigned structures. E.g. for 3g δH(CDCl3, TMS): 1.15-1.30 (2t, 6H, 2-OCH2CH3), 2.31 (s, 3H), 3.90-4.65 (2q, 4H, 2-OCH2CH3), 7.13-7.33 (m, 4H); IR (neat): v 1608 (Ar), 1278 (P=O), 1032, 966 cm−1 (P-O-Et).
