A new procedure for carrying out the benzil–benzilic acid rearrangement in the solid state has been developed which provides a new route to synthesize the pharmacologically interesting anticonvulsant dilantin.
References
1.
von LiebigJ., Justus Liebigs Ann. Chem., 1838, 25, 27.
DoeringW. E., and UrbanR. S., J. Am. Chem. Soc., 1956, 78, 5938; I. Kasiwagi, Bull. Chem. Soc. Jpn., 1926, 1, 66; C. G. Screttas, M. Micha-Screttas and C. T. Cazianis, Tetrahedron Lett., 1983, 24, 3287; T. W. Evans and W. M. Dehn, J. Am. Chem. Soc., 1930, 52, 252; S. Selman, Diss. Abstr., 1960, 20, 3083.
4.
TodaF., Acc. Chem. Res., 1995, 28, 480; F. Toda, K. Tanaka, Y. Kagawa and Y. Sakaino, Chem. Lett., 1990, 373.
5.
ChenS.-T., YuH.-M., ChenS.-T., and WangK.-T., J. Chin. Chem. Soc., submitted.
