Rosuvastatin Demonstrates Greater Reduction of Low-Density Lipoprotein Cholesterol Compared with Pravastatin and Simvastatin in Hypercholesterolaemic Patients: A Randomized,Double-Blind Study

Abstract

Background Rosuvastatin (Crestor), a new, highly efficacious statin, has demonstrated dose-dependent low-density lipoprotein cholesterol (LDL-C) reductions of up to 65% in a dose-ranging programme with doses of 1 to 80 mg.

Design A randomized, double-blind multicentre trial compared rosuvastatin with commonly used starting doses of pravastatin and simvastatin to determine relative efficacy in LDL-C reduction and impact on other lipid parameters in primary hypercholesterolaemia.

Methods and results A total of 502 patients (≥ 18 years; LDL-C ≥ 4.14 mmol/l [160mg/dl] and <6.50mmol/l [250mg/dl] and triglycerides <4.52 mmol/l [400mg/dl]) were randomized to 12 weeks of rosuvastatin 5 mg (n=120) or 10mg (n=115), pravastatin 20 mg (n=137) or simvastatin 20 mg (n=130). Rosuvastatin 5 and 10mg reduced LDL-C by 42 and 49%, respectively, compared with 28% for pravastatin (P< 0.001 versus both rosuvastatin doses) and 37% for simvastatin (P<0.01 versus rosuvastatin 5mg; P < 0.001 versus 10mg). National Cholesterol Education Program Adult Treatment Panel II (NCEP ATP II) goals were achieved by 87% of rosuvastatin 10mg patients, 71% of rosuvastatin 5 mg patients, 53% of pravastatin patients, and 64% of simvastatin patients; similar proportions of patients achieved NCEP ATP III goals. European Atherosclerosis Society (EAS) goals were achieved by 83, 63, 20 and 50% of patients, respectively. All study treatments were well tolerated.

Conclusions Both doses of rosuvastatin were more effective than pravastatin and simvastatin in meeting NCEP ATP II and EAS LDL-C targets. Rosuvastatin 10mg was more effective than pravastatin and simvastatin in meeting NCEP ATP III targets.