In vitro hemolytic properties’ assessment of K 2 Ti 6 O 13 nanowires

Abstract

K₂Ti₆O₁₃ nanowires are excellent inorganic nanomaterials, which have high value and huge potential use in many fields. However, the biocompatibility of K₂Ti₆O₁₃ nanowires will be directly related to its application. But the quantity of its hemocompatibility reports is limited. In this study, K₂Ti₆O₁₃ nanowires were first synthesized by sol–gel/hydrothermal combined method. In view of its biosafety, the hemocompatibility of the novel nanomaterial was investigated by a hemolysis test. Fresh whole blood was drawn by venipuncture from a healthy human volunteer. The absorbance of free hemoglobin in the clear supernatant of the blood mixtures in contact with the test, positive and negative control groups was measured by ultraviolet–visible spectrophotometer for evaluating the hemolysis ratio. The hemolysis ratio of the test group is far lower than the standard of 5%. And the results indicate that the novel material has no hemolytic effect and has application prospects in the fields of biomedicine and biomaterials.