We have synthesized a hydrogel with long polyethyleneoxide (PEO) chains and evaluated its hemocompatibility. The hydrogel significantly suppressed the adsorption of plasma proteins and adhesion of platelets. In addition, the marked retardation of thrombus formation on its surface was recognized. These findings seems to be caused by the volume restriction effects derived from the highly flexible and hydrophilic PEO chains.
Andrade, J.D. , H.B. Lee, M.S. Jhon, S.W. Kim and J.B. Hibbs, Jr.Trans. Am. Soc. Artif. Intern. Organs , 19:1 ( 1973).
2.
Leonard, E.F., S. Kochwa, R.S. Litwak and R.E. Rosenfield .N.H.L.I. report No. NOI HB-3-291D-2, National Institutes of Health, Washington, DC (1976).
3.
Muzykewicz, K.J. , E.B. Crowell, Jr., A.P. Hart, M. Schults, C.G. Hill, Jr. and S.L. Cooper.J. Biomed. Mater. Res., 9:487 (1975).
4.
Pennington, C.J., L.L. Peterson, J.H. Rotaru and J.B. Boatman.N.H.L.I. report No. PH43-67-1404-F-3, National Institutes of Health, Washington, DC (1971).
Abuchowski, A., T. VanEs, N. C. Palczuk and E. F. Davis. J. Biol. Chem., 252:3578 (1977).
8.
Nagaoka, S., M. Shiota, Y. Mori and T. Kikuchi.Kobunshi Ronbunshu, 38: 571 (1981).
9.
Mori, Y., S. Nagaoka, H. Takiuchi, T. Kikuchi, N. Noguchi, H. Tanzawa and Y. Noishiki.Trans. Am. Soc. Artif. Intern. Organs, 28:459 (1982).
10.
Nagaoka, S. , Y. Mori, H. Takiuchi, K. Yokota, H. Tanzawa and S. Nishiumi.Polymers as Biomaterials. Plenum Publishing Corporation, p. 361 (1984).
11.
Nakao, A., K. Ohkura, T. Nonami, A. Harada, H. Takagi and Y. Mori.Trans. Am. Soc. Artif. Intern. Organs, 32:319 (1986).
12.
Ratonoff, O.D. and H. Saito.Ann. N.Y. Acad. Sci., 283:88 (1977).
13.
Sakata, Y. and N. Aoki.J. Clin. Invest., 65:290 (1980).
14.
Mori, Y., S. Nagaoka, H. Takiuchi, R. Terada, S. Nishiumi, H. Tanzawa, A. Kuwano and H. Miyama.Progress in Artificial Organs 1983. Cleveland: ISAO Press, p. 825 (1984).
