Serum sialic acid levels were measured in 80 healthy subjects, in 60 patiens with benign tumors and in 110 patients with oral cancer. It was shown that these levels were significantly elevated in oral cancer patients compared to healthy controls and patients with benign tumors (p < 0.01); they were higher in patients with stage III and stage IV disease than in those with stage I and II disease (p < 0.01). However, no difference was observed between healthy controls and stage I and II cancer patients. The results of this study suggest that the determination of sialic acid levels may be of value in the diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging is limited.
KatapodisN., HirshautY., GellerN.L., StockC.C.Lipid-associated sialic acid test for the detection of human cancer.Cancer Res1982; 42: 5270–5.
2.
HorganI.E.Total and lipid-bound sialic acid levels in sera from patients with cancer.Cli Chim Acta1982; 118: 327–31.
3.
KakariS., AvgoustatosG., FerderigosA.S.Total and lipid-bound sialic acid in the cerebrospinal fluid of patients with brain tumors.Anticancer Res1984; 4: 313–6.
4.
KakariS., MichaelipidisG., BesbeasS.Serum lipid-bound sialic acid as a marker of gastrointestinal cancer.Anticancer Res1984; 4(Suppl 1): 3–6.
5.
SalvagnoL., FerrazziE., SileniV.C.Lipid-bound sialic acid in cancer patients.Tumori1985; 71: 127–33.
6.
MunjalD.D., PickenJ., PritchardJ.Combined measurement and significance of lipid-bound sialic acid and carcinoembryonic antigen in detection of human cancer.Diagn Immunol1984; 2: 36–43.
7.
GailM.H., MuenzL., McIntireK.R.Multiple markers for lung cancer diagnosis: validation of models for advanced lung cancer, JNCI1986; 76: 805–16.
8.
GailM.H., MuenzL., McIntireK.R.Multiple markers for lung cancer diagnosis: validation of models for localised lung cancer.JNCI1988; 80: 97–101.
9.
DnisteianA.M.Lipid bound sialic acid as a marker in lung cancer.Clin Chem1985; 31: 982–6.
10.
KrolicowskiF.J., RileyW.M., ProrokJ.J.Serum sialic acid levels in lung cancer patients.Pharmacology1976; 14: 47.
11.
PlucinskyM.C.Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and different degree of metastatic involvement.Cancer1986; 58: 2680.
12.
KhanderiaU., KellerJ.H., GrossmanH.B.Serum sialic acid is a biologic marker for malignant disease.J Surg Oncol1983; 23: 163–6.
13.
ShambergerB.J.Serum sialic acid in normals and in cancer patients.J Clin Chem Clin Biochem1984; 22: 647–51.
14.
AminnoffD.Method for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.Biochem J1961; 81: 384–92.
15.
YogeeswarmanG.Cell surface glycolipids and glycoproteins in malignant transformation.Adv Cancer Res1983; 38: 289–350.
16.
KhadapkurS.V., ShethN.A., BhideS.V.Independence of sialic acid levels in normal and malignant growth.Cancer Res1975; 35: 1520–3.
17.
SchwartzP.E., ChambersS.K., ChambersJ.T., GutmanJ., KatopodisN., FoemmelR.Circulating tumor markers in the monitoring of gynecologic malignancies.Cancer1987; 60: 353–61.
18.
KakariS., StringouE., ToumbisA.S.Five tumor markers in lung cancer: significance of total and lipid-bound sialic acid.Anticancer Res1991; 11: 2107–10.
19.
RopkaM.E., GoodwingW.J., LevineP.A.Effective head and neck tumor markers.Arch Otolaryngol Head Neck Surg1991; 117: 1011–4.
20.
BhatavdekarJ.M., PatelD.D., VoraH.H., BalarD.B.Squamous cell carcinoma antigen and protein-bound sialic acid in the management of head and neck cancer.Int J Biol Markers1991; 6: 237–40.
