A summary is given of data on the clinical experience with the antimelanoma antibody 225.28S in ophthalmology and the tissue expression of the high molecular weight-melanoma associated antigen in choroidal melanoma. Results are discussed in relation to other detection methodsfor ocular melanoma currently employed by the ophthalmologist.
van DijkR.A.The P32-test and other methods in the diagnosis of intraocular tumors. Dissertation. The Hague, The NetherlandsDr W Junk BV Publishers, 1978; 57.
2.
ColemanD.J., AbramsonD.H., JackR.L., FranzenL.A.Ultrasonic diagnosis of tumors of the choroid.Arch Ophthalmol1974; 91: 344–54.
PauwelsE.K.J., van LangeveldeA., KaspersenF.M., Boer IwemaR., OosterhuisJ.A.Non-invasive detection of ocular melanoma: a patient study with 67Ga-and 99mTc-citrate and animal studies with a iodo-quinoline analogue.Nucl Med Comm1980; 1: 224–32.
6.
LambrechtR.M., PackerS., AtkinsH.L.Differential radioactivity monitor for non-invasive detection of ocular melanoma.Nucl Med Comm1984; 5: 381–6.
7.
FrankenN.A.P., van DelftJ.L., van LangeveldeA.Scintimetric detection of choroidal malignant melanoma with (123)-5-iodo-2-thiouracil.Ophthalmolo-gica1986; 93: 248–54.
8.
LambrechtR.M., PackerS., WolfA.P., LloydD., AtkinsH.L.Detection of ocular melanoma with 4-(3-dimeth-ylaminopropylamino)-7-(123I)-iodoquinoline.J Nucl Med1984; 25: 800–4.
9.
KohlerG., MilsteinC.Continuous cultures of fused cells secreting antibody of predefined specifity.Nature1975; 256: 495.
10.
BrownJ.P., WoodburyR.G., HartC.E., HellströmI., HellströmK.E.Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.Proc Natl Acad Sci USA1981; 78: 539–43.
11.
BumolT.F., WalkerL.E., ReisfeldR.A.Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans.J Biol Chem1984; 259: 12733–41.
12.
CarrelS., AccollaR.S., CarmagnolaA.L., MachJ.P.Common human melanoma associated antigens detected by monoclonal antibodies.Cancer Res1980; 40: 2523–8.
13.
DippoldW.G., LloydK.O., LiL.T.L., IkedaH., OettgenH.F., OldL.J.Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.Proc Natl Acad Sci USA1980; 77: 6114–8.
14.
HellströmI.H., GarriguesJ., CabascoL., MoselyG.H., BrownJ.P., HellströmK.E.Studies of a high molecular weight human melanoma-associated antigen.J Immunol1983; 130: 1467–72.
15.
ImaiK., MolinaroG.A., FerroneS.Monoclonal antibodies to human melanoma associated antigens.Transplant Proc1980; 12: 380–3.
16.
ImaiK., NataliP.G., KayN.E., WilsonB.S., FerroneS.Tissue distribution and molecular profile of a differentiation antigen detected by a monoclonal antibody (345.134S) produced against human melanoma cells.Cancer Immunol Immunother1982; 12: 159–66.
17.
ImaiK., WilsonB.S., BigottiA., NataliP.G., FerroneS.A.94000-dalton glycoprotein expressed by human melanoma and carcinoma cellsJ Natl Cancer Inst1982; 68: 761–9.
18.
JohnsonJ.P., Demmer-DieckmanM., MeoT., HaddenM.R., RiethmullerG.Surface antigens of human melanoma cells defined by monoclonal antibodies: 1. Biochemical characterization of two antigens found on cell lines and fresh tumors of diverse tissue origin.Eur J Immunol1982; 11: 825–31.
19.
LarsonS.M., CarrasquilloJ.A., McGuffinR.W.Use of I-131 labeled murine Fab against a high molecular weight antigen of human melanoma: preliminary experience.Radiology1985; 155: 487–92.
20.
LiaoS.K., ClarkeB.J., KwongP.C., BrickerdenA., GallieB., DentP.B.Common neuroectodermal antigens on human melanoma, neuroblastoma, retinoblastoma, glioblastoma, and fetal brain revealed by hybridoma antibodies raised against melanoma cells.Eur J Immunol1981; 11: 450–4.
21.
LiaoS.K., ClarkeB.J., KhosraviM., KwongP.C., Brick-endenA., DentP.B.Human melanoma specific oncofetal antigen defined by a mouse monoclonal antibody.Int J Cancer1982; 30: 573–80.
22.
SteplewskiZ., HerlynM., HerlynD., ClarkW., KoprowskiH.Reactivity of monoclonal antimelanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma.Eur J Immunol1979; 9: 94–6.
23.
DamatoB.E., CampbellA.M., McGuireB.J., LeeW.R., FouldsW.S.Monoclonal antibodies to human primary uveal melanomas demonstrate tumor heterogeneity.Invest Ophthalmol Vis Sci1986; 27: 1362–7.
24.
DonosoL.A., ShieldsJ.A., AugsburgerJ.J., WhitmanJ., ArbizoV.Antigenic and cellular heterogeneity of primary uveal malignant melanomas.Arch Ophthalmol1986; 104: 106–10.
25.
BomanjiJ., GarnerA., PrasadJ.Characterisation of ocular melanoma with cutaneous melanoma antibodies.Br J Ophthalmol1987; 71: 647–50.
26.
FolbergR., DonosoL.A., AtkinsonB.F., ErnstC.S., HerlynM., ArbizoV.V.An antimelanoma monoclonal antibody and the histopathology of uveal melanomas.Arch Ophthalmol1985; 103: 275–9.
27.
Van der PolJ.P., JagerM.J., De Wolff-RouendalD., RingensP.J., VennegorC., RuiterD.J.Heterogenous expression of melanoma-associated antigens in uveal melanomas.Curr Eye Res1987; 6: 757–65.
28.
BuraggiG., TurrinA., CascinelliN.Radioimmu-nodetection of melanoma: preliminary results of a prospective study.Int J Biol Makrers1986; 1: 47–54.
29.
SiccardiA.G., BuraggiG.L., NataliP.G., ScassellatiG.A., VialeG., FerroneS. and the European Multicentre Study Group-European multicentre study on melanoma immunoscintigraphy by means of 99mTc-99mTc-labeled monoclonal antibody fragments.Eur J Nucl Med1990; 16: 317–23.
30.
BomanjiJ., HungerfordJ.L., GranowskaM., BrittonK.E.Radioimmunoscintigraphy of ocular melanoma with 99mTc labeled cutaneous melanoma antibody fragments.Br J Ophthalmol1987; 71: 651–8.
31.
SchalingD.F., van KroonenburghMJPG, BorsjeR.A.Radioimmunoscintigraphy with melanoma associated monoclonal antibody fragments in ocular melanoma.Graefe's Arch Clin Exp Ophthalmol1989; 227: 291–4.
32.
ScheidauerK., MarklA., LeinsingerG.Immunoscintigraphy in intraocular malignant melanoma.Nucl Med Comm1988; 9: 669–79.
33.
WilsonB.S., ImaiK., NataliP.G., FerroneS.Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies.Int J Cancer1981; 28: 293–300.
34.
WilsonB.S., GiacominiP., ImaiK.Human melanoma associated antigens identified with monoclonal antibodies.La Ricerca Clin Lab1982; 12: 517.
35.
NataliP.G., BigottiA., NicotraM.R.Analysis of the antigenic profile of uveal melanoma lesions with anti-cutaneous melanoma-associated antigen and anti-HLA monoclonal antibodies.Cancer Res1989; 49: 1269–74.
36.
GiacominiP., VegliaF., Cordiali FeiP., RehleT., NataliP.G., FerroneS.Level of membrane bound high-mole-cular-weight melanoma associated antigen and a cytoplasmic melanoma-associated antigen in surgically removed tissues and in sera from patients with melanoma.Cancer Res1984; 44: 1281–7.
37.
NgA.K., GiacominiP., KantorR., FerroneS.Molecular heterogeneity and shedding of a high-molecular-mass melanoma-associated antigen identified with monoclonal antibodies.Clin Chem1982; 28/12: 2347–50.
38.
SchlingemannR.O., RietveldF.J.R., De WaalR.M.W., FerroneS., RuiterD.J.Does the melanoma-associated high-molecular-weight antigen play a role in pericyte function during tumor angiogenesis?Proc Am Ass Cane Res1989; 30: 378.
39.
SchalingD.F., Van der PIJ.P., JagerM.J., Van KroonenburghMJPG, OosterhuisJ.A., RuiterD.J.Immunoscintigraphy and immunohistochemistry with melanoma associated monoclonal antibody in choroidal melanoma.Br J Ophthalmol1990; 74: 538–41.
BomanjiJ., HungerfordJ.L., GranowskaM., BrittonK.E.Uptake of 99m Tc labelled (Fab')2 fragments of monoclonal antibody 225.28S by a benign ocular naevus.Eur J Nucl Med1988; 14: 165–6.
43.
SchalingD.F., OosterhuisJ.A., PauwelsE.K.J.Ocular melanoma (Letter to the editor).Br J Ophthalmol1990; 74, 4: 254–5.
44.
NataliP.G., BigottiA., CavaliereR., NicotraM.R., FerroneS.Phenotyping of lesions of melanocyte origin with monoclonal antibodies to melanoma-associated antigens and to HLA antigens.J Natl Cane Inst1984; 73: 13–24.
