A series of 65 cases of different histological types of breast carcinoma was investigated for the immunohistochemical location of the estrogen receptor-related, 29 kD phosphoprotein using the ER-D5 monoclonal antibody.
The ER-D5 response is heterogeneous in relation to some therapeutic limitations and is correlated with histopathological features of the tumors and survival. The main parameters for evaluation of breast cancers are reviewed, both those that are statistically correlated and those that are not apparently always correlated but are known to have considerable biological meaning, such as the ER-status of tumors.
FisherE.R., GregorioR.M., FisherB.The pathology of invasive breast cancer: a syllabus derived from findings of National Surgical Adjuvant Breast Project (Protocol n. 4). Cancer1975; 36: 1–84.
2.
BloomH.J.G., RichardsonW.W.Histological grading and prognosis in breast cancer. Br J Cancer1957; 9: 359–77.
3.
CofferA.I., LewisK.M., BrokasA.J., KingR.J.B.Monoclonal antibody against a component related to soluble estrogen receptor. Cancer Res1985; 45: 3686–93.
4.
KingR.J.B., CofferA.L., GilbertJ.Histological studies with a monoclonal antibody raised against a partially purified estradiol receptor preparation from human myometrium. Cancer Res1985; 45: 5728–33.
5.
SternbergerL.A.Immunocytochemistry. 2nd ed. New York: John Wiley and Sons, 1979.
6.
HorwitzK.B., McGuireW.L.Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science1975; 89: 726–7.
7.
KiangD.T., KennedyB.J.Factor affecting estrogen receptors in breast cancer. Cancer1977; 40: 1571–6.
8.
LeeS.H.Cancer cells estrogen receptor of human mammary carcinoma. Cancer1979; 44: 712–7.
9.
PoulsenS.H., JensenJ., HermansenC.Human breast cancer: heterogeneity of estrogen binding sites. Cancer1981; 48: 1791–9.
10.
TaylorC.R., CooperC.L., KurmanR.J., GoebelsmannU., MarklandF.S.Detection of estrogen receptor in breast and endometrial carcinoma by the immunoperoxidase technique. Cancer1981; 47: 2634–40.
11.
DavisB.W., ZavaD.T., LovherG.W., GoldhirshA., HartmannW.H.Receptor heterogeneity of human breast cancer as measured by multiple intratumoral assays of estrogen and progesterone receptor. Eur J Cancer1984; 20: 373–82.
12.
CrawfordD., CowanS., HyderS., Mc MenaminM., SmithD., LeakeR.New storage for human tumor prior to estrogen receptor measurement. Cancer Res1984; 44: 2348–51.
13.
GeyerH., EberlM., HornbergerB.Influence of tissue heterogeneity on the determination of steroid receptors. J Cancer Res Clin Oncol1985; 110: 141–4.
14.
KingR.J.B., De SombreE.R., JensenE.V., GreeneG.L.Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumor. Cancers Res1985; 45: 293–304.
15.
PoulsenS.H., OzzelloL., KingW.J., GreeneG.L.The use of monoclonal antibodies to estrogen receptors (ER) for immunoperoxidase detection of ER in paraffin sections of human cancer tissue. J Histochem Cytochem1985; 33: 87–92.
16.
GuazziA., BozzettiC., RivaI., ZaffeD., CocconiG.Relationship between estrogen receptor concentration and cytomorphometry in breast cancer. Cancer1985; 56: 1972–6.
17.
PertschukL.P., EisenbergK.B., CarterA.C., FeldmanJ.G.Heterogeneity of estrogen binding sites in breast cancer: morphologic demonstration and relationship to endocrine response. Breast Cancer Res Treat1985; 5: 137–47.
18.
DawsonP.J., KarrisonT., FergusonD.J.Histologic features associated with long-term survival in breast cancer. Hum Path1986; 17: 1015–21.
19.
Vollenweider-ZerarguiL., BarreletL., WongY., Lemarchand-BéraudT., GomezF.The predictive value of estrogen and progesterone receptors’ concentration on the clinical behavior of breast cancer in women. Clinical correlation on 547 patients. Cancer1986; 23: 75–80.
20.
CharpinC., MartinP.M., JacquemierJ., LavautM.N., Pourreau-SchneiderN., TogaM.Estrogen receptor immunocytochemical assay (ER-ICA): computerized image analysis system, immunoelectron microscopy, and comparison with estradiol binding assays in 115 breast carcinomas. Cancer Res1986; Suppl 4271S–7S.
21.
ShintakuI.P., SaidJ.W.Detection of estrogen receptors with monoclonal antibodies in routinely processed formalin-fixed paraffin sections of breast carcinoma. Am J Clin Pathol1987; 87: 161–7.
22.
KodamaF., GreeneG.L., SalmonS.E.Relation of estrogen receptor expression to clonal growth and anti-estrogen effects on human breast cancer cells. Cancer Res1985; 45: 2720–4.
23.
McGuireW.L., HorwitzK.B., PearsonO.H., SegaloffA.Current status of estrogen and progesterone receptors in human breast cancer. Seminars Oncol1983; suppl 4: 2–6.
24.
AntoniadesK., SpectorH.Correlation of estrogen receptors levels with histology and cytomorphology in human mammary cancer. Am J Clin Pathol1979; 74: 497–503.
25.
MontescoM.C., PluchinottaA., PiffanelliA., PelizzolaD., GiovanniniG., Arslan-PagniniC.Hormone receptors and breast cancer: correlations with clinical and histologic features. Tumori1984; 70: 445–50.
26.
StegnerH.E., BrorkenW., BahnsenJ.Relation between receptor status and ultrastructure in breast cancer: E + P + versus E-P-. Path Res Pract1986; 181: 377–81.
27.
SicaV.I recettori ormonali quali indici biochimici dei tumori ormono-sensibili: utilità a prospettive. In: CacioppoF., CastagnettaL., eds. Aspetti biochimici e clinici dei tumori ormono-sensibili.Palermo: Ed. Clemenza. 1979; 23–32.
28.
JensenE.V., De SombreE.R., JungblutP.W.Estrogen receptors in hormone-responsive tissues and tumors. In: WisslerR.W., DaoT.L., WoodS.Jr., eds. Endogeneous factors influencing host-tumor balance.Chicago: Univ of Chicago Press, 1967; 15–30.
29.
JensenE.V., GreeneG.L., ClossL.E., De SombreE.R., NadjiM.Receptors reconsidered: a 20 year perspective. Rec Progr Horm Res1982; 38: 1.
30.
HorwitzK.B., McGuireW.L.Estrogen control of progesterone receptors in human breast cancer. J Biol Chem1978; 253: 2223–30.
31.
NenciI., FabrisG., MarchettiE., MarzolaA.Intracellular flow of particular steroid-receptor complexes in steroid target cells. Virch Arch B Celle Pathologie1980; 32: 139–42.
32.
McGuireW.L., ClarkG.M.The prognostic role of progesterone receptors in human breast cancer. Seminars Oncol1983; 10 Suppl 4: 2–6.
33.
MohammedR.H., LakatuaD.J., HausE., YashinenW.J.Estrogen and progesterone receptors in human breast cancer. Correlation with histologic subtype and degree of differentiation. Cancer1986; 58: 1976–81.
34.
RosenP.P., MenendezC.J., NisselbaumJ.S.Pathological review of breast lesions analyzed for estrogen receptor protein. Cancer Res1975; 35: 3187–94.
35.
SilfverswardC., GustafssonJ.A., GustafssonS.A.Estrogen receptor concentration in 269 cases of histologically classified human breast cancer. Cancer1980; 45: 2001–5.
36.
Mc CartyK.S.Jr., BartonT., FetterB.Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinoma. Cancer1980; 46: 2851–8.
37.
ParlF.F., WagnerR.K.The histopathological evaluation of human breast cancers in correlation with estrogen receptor values. Cancer1980; 46: 362–7.
38.
FisherE.R., RedmondC.K., LiuH., RocketteH., FisherB., and collaborating NSABP Investigators. Correlation of estrogen receptor and pathologic characteristics of invasive breast cancer. Cancer1980; 45: 349–53.
39.
LesserM.L., RosenP.P., SenieR.T., DuthieK., Henendez-BotetC., SchwartzM.K.Estrogen and progesterone receptors in breast carcinoma: correlation with epidemiology and pathology. Cancer1981; 48: 299–309.
40.
PoulsenS.H., OzzelloL., AndersenJ.Oestrogen receptors in human breast cancer. Problems of correlation with histopathological features. Virch Arch Pathol Anat1982; 397: 103–8.
41.
GallagerH.S.Pathologic types of breast cancer: their prognoses. Cancer1984; 53: 623–9.
42.
CampobassoO., ConcinaS., CozzaniC.Correlazioni tra determinazione biochimica ed istochimica dei recettori ormonali nei carcinomi della mammella con eta delle pazienti, stadio e tipö istologico. Pathologica1987; 79: 53–9.
43.
HumeniukV., ForrestA.P.M., HawkinsR.A.Elastosis and primary breast cancer. Cancer1983; 52: 1448–52.
44.
GlaubitzL.C., BowenJ.H., CoxE.B., Mc CartyK.S.Elastosis in breast cancer. Correlation with sex steroid receptors and comparison with clinical outcome. Arch Pathol Lab Med1984; 108: 27–30.
45.
GiriD.D., LondsdaleR.N., DangerfieldV.J.M., HarrisS.C., ParsonsM.A., UnderwoodJ.C.E.Clinicopathological significance of intratumoral variations in elastosis grades and oestrogen receptor status of human breast cancer. J Path1987; 151: 297–303.
46.
RollandP.H., JacquilierJ., MartinR.M.Histologic differentiation in human breast cancer is related to steroid receptors and stromal elastosis. Cancer Chemother Pharmacol1980; 5: 73–7.
47.
HorieA., NomuraY., StemmermannG.Histopathological features and their association with steroid receptors in women with breast cancer in Fuknoka, Japan. Acta Path Jap1984; 34: 229–39.
48.
Pucci MinafraI., MinafraS., TomasinoR.M., SciarrinoS., TinerviaR.Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth. J Submicr Cytol1986; 18: 795–805.
