Five tumor markers (CEA, Ferritin, CA-50, TPA and SCC) were assayed in 54 patients with ear, nose and throat (ENT) cancers in early and advanced stages. The specificity of these markers always exceeded 95%. Their sensitivity ranged from 13 to 43%, and reached 72% as a combination of all five markers.
No distinction was found between early and advanced stage of illness. These markers seem to have no distinct function in ENT oncological diagnosis and follow-up because objective data is easily available even in early tumors.
BombardieriE.I marker tumorali in oncologia: aspetti attuali di un problema antico.Biomarcatori in Oncologia1984; 1/1: 3–7.
2.
KholerG., MilsteinC.Continuous cultures of fused cells secreting antibody of predefined specificity.Nature (London)1975; 256: 495–7.
3.
HerzenbergL.A., MilsteinC.Cell hybrids of myelomas with antibody cells and T-lymphocytes with T-cells. In: Weir DM, ed. Handbook of experimental immunology.London: Blackwell Scientific Publications,1978; 25: 1–7.
4.
BracciottiC., DuratiE., BaniB.. Ricerche sul valore diagnostico di alcuni marcatori fenotipici nei tumori cervico-facciali.Atti del 73° Congresso Nazionale S.I.O.,Roma1986.
5.
CarrecaI., MellinaL., CignoA.I markers dei tumori della testa e del collo. Atti del XI Congresso Nazionale di Oncologia: I tumori del rene - I markers tumorali, Bologna 12-14 dicembre 1985.
6.
De VincentisM., BiserniA., GalloA.Diagnosi precoce del cancro laringeo.Il Valsalva1983; 59: 233–43.
7.
VeltriR.W., MaximP.E.Tumor immunity and tumor markers in head and neck cancer. In: WolfG.T., ed. Head and neck oncology.Dordrecht (NL): B Martinus Nijhoff, 1984; 411–30.
8.
FiorellaR., Di NicolaN., GiannubiloC., FacondoM.Antigene carcinoembrionario e carcinoma laringeo: sensibilità e valore predittivo di metastasi.Acta Otorhinol Ital1986; 6/2: 127–32.
9.
LunghiF., FrassonP., LunghiM.Antigene carcino-embrionale e carcinoma del distretto testa-collo.Acta Otorhinol Ital1985; 5: 271–6.
10.
RossiM.Denaro A, Caruso R, Mazzarino C, Messina L, Malaponte G. L'antigene carcino-embrionale nel monitoraggio del carcinoma della laringe.Acta Otorhinol Ital1984; 1: 3–7.
11.
SilvermannN.A., AlexanderJ.C., ChretienP.B.CEA levels in head and neck cancer.Cancer1976; 37: 2204–10.
12.
MaximP., VeltriR.Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck.Cancer1986; 57: 305–11.
13.
ZerilloG., RestivoS., SpecialeR., CupidoG., CarrecaI., OlivieriD.Impiego di biomarcatori tumorali (TPA e CA 50) nel follow-up clinico delle neoplasie della testa e del collo.Atti del 73° Congresso Nazionale S.I.O., Roma 1986.
14.
KatoH., MoriokaH., AramakiS., TirigoeT.Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma.Cell and Mol Biol1979; 25: 51–6.
15.
KatoH., MoriokaH., TsutsuiH., AramakiS., TirigoeT.Value of tumor-antigen (TA-4) of squamous cell carcinoma in predicting the extent of cervical cancer.Cancer1982; 50: 1294–6.
16.
WernerE., JonasT.J.Tumor markers in the management of squamous cell carcinoma of the head, neck and lung.Princeton: Excerpta Medica1987; 8–32.
17.
BombardieriE.Utilità clinica dei metodi radioimmunologici per il dosaggio dei markers tumorali. In: VeronesiU., EmanuelliH., De LenaM., GuzzonA., RilkeF., SpinelliP., eds. Progressi diagnostici in Oncologia.Milano: Case Ed Ambrosiana1980; 199–207.
18.
BombardieriE., RinghiniR., BuraggiG.L.CEA-antigene carcino-embrionale. Biologia e clinica. I° ed.Saluggia, Italy: Monografie di Immunologia Sorin Biomedica1985: 64.
19.
OreficeS., GennariL., MonC., CostaA.The value of the CEA-test in the diagnosis of the metastases of adenocarcinomas of the gastroenteric tract.Tumori1981; 67: 109–12.
