Gastrointestinal biopsies from 18 members of a family with Lynch Syndrome II were evaluated and immunocytochemical studies were made to characterize the phenotypic expression of the tissue's immune populations. The intestinal findings suggest polyclonal B-cell activation related to the T-helper distribution. Our evaluation provides no specific information so far on the management of patients with Lynch Syndrome II.
LynchH.T., KimberlingW.J., AlbanoW.Hereditary nonpolyposis colorectal cancer. I. Clinical description of resource.Cancer1985; 56: 934–8.
2.
BolandoC.R., TroncaleF.J.Familial colonic cancer in the absence of antecedent polyposis. Ann. Inter.Med.1984; 100: 700–1.
3.
LynchH.T., LynchJ.F.Genetics and colorectal cancer. In Familial Cancer, 1st Int Res Conf, Muller Weber (eds) 1985; 72–7.
4.
TwomeyJ.J., SharkeyO.An adaptation of the mixed leucocyte culture test for use in evaluating lymphocyte and macrophage function.J Immunol1972; 108: 984–90.
5.
LynchH.T., LynchP.M., AlbanoW., LynchJ.F.The Cancer Syndrome: A Status Report.Dis Col and Rect1981; 24: 311–22.
6.
MartinF., CaignardA., JeanninJ.F., OlssonO., MartinM.S.Role of host-tumor interaction in the growth control of chemically induced colon cancer. In: SherlockP., MorsonB.C., BarbaraL., VeronesiU., eds. Precancerous lesions of the gastrointestinal tract.New York: Raven Press, 1983; 237–40.
7.
CristofaroG., CarusoM.L., AttoliniA., Di MatteoG., GiorgioP., TrabuccoM.. Cancer Family Syndrome (Lynch Syndrome II: Preliminary Report of New Phenot-ypic Findings).Familial Cancer, 1st Int Res Conf, Muller Weber (eds) 1985; 85–7.
