Kyrle's disease is a rare perforative skin dermatosis. It was first described in 1916 by J. Kyrle, under the name of hyperkeratosis follicularis et parafollicular in cutem penetrans. It refers to a disorder of keratinization, which usually appears as scattered or grouped hyperkeratotic papules on the extremities and the trunk characterized by extrusion of keratotic material into an epidermal invagination.
KasiakouSPeppasGKapaskelisAFalagasM. Regression of skin lesions of Kirle's disease with clindamycin: Implications for an infectious component in the etiology of the disease. J Infection2005; 55:139–40.
2.
KhalifaMSlimIKaabiaNBahriFTrabelsiALetaiefAO. Regression of skin lesions of Kyrle's disease with metronidazole in a diabetic patient. J Infect2007; 55(6):e 139–40.
3.
ViswanathanSNarurkarSDRajpalANagpurNGAvasareSS. Rare presentation of Kyrle's disease in siblings. Indian J Dermatol2008; 53(2):85–7.
4.
Wolff Schreiner Ech. Kyrle's disease and perforating disorders. 5th edNew York: Mc Graw Hill Book p. 631–6.
5.
MommersJMter MeulenACvan ErpPEvan de KerkhofPC. Influence of tacalcitol on cell cycle kinetics of human keratinocytes following standardized injury. Skin Pharmacol Appl Skin Physiol1999; 12(4): 174–81.
