Relationship between global limb anatomic staging system (GLASS) and short- and mid-term endovascular treatment outcomes in chronic limb-threatening ischemia (CLTI) patients with infra-inguinal lesions

Abstract

Background

Chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease (PAD), results in significant morbidity and mortality. The Global Limb Anatomic Staging System (GLASS) is a new tool designed to predict outcomes in CLTI patients undergoing endovascular treatments, yet its relationship with short-term outcomes requires further investigation.

Objective

This study evaluates the correlation between GLASS staging and short-term outcomes in CLTI patients treated with endovascular procedures for infrainguinal lesions.

Methods

Prospective cohort of 160 CLTI patients who received endovascular treatment for infrainguinal lesions was analyzed. GLASS staging was assigned based on angiographic data, and short-term outcomes, including immediate technical failure (ITF), limb-based patency (LBP) at 1 year, and amputation-free survival (AFS) at 1 year, were measured.

Results

In the cohort of patients, a significant association was found between GLASS staging and short-term outcomes. Higher GLASS stages correlated with increased ITF rates, lower 1-year LBP rates, and reduced 1-year AFS rates. Specific GLASS parameters, such as femoropopliteal and infrapopliteal scores, independently predicted short-term outcomes.

Conclusion

This study indicates that GLASS staging is a useful prognostic tool for assessing short-term outcomes in CLTI patients undergoing endovascular treatment for infrainguinal lesions. Utilizing GLASS staging in clinical settings may enhance treatment planning and patient prognoses.