In this study, we aimed to investigate the relationship between adult degenerative scoliosis (ADS) and the aortic plaques and diameters.
Method
We included 219 patients with ADS and 100 control patients without ADS. Diameters of ascending, arch, descending and abdominal aorta and number, localization and types of the aortic plaques, and the Cobb angles of all patients were measured from computed tomography (CT) images. We divided the patients with ADS into three groups according to the Cobb angle, and divided them into four groups according to level of spine deformity.
Results
The patients with ADS had a larger aorta and more aortic plaques (both, p < 0.001). The patients with ADS had more fibro-fatty and mix plaques (both, p < 0.001). The patients with severe ADS had larger diameters of the ascending and arch of the aorta (p = 0.026 and p = 0.027, respectively). The patients with the main thoracic curve had a larger ascending aorta and the patients with a thoracolumbar curve had more aortic plaques (p = 0.035 and p = 0.029, respectively). In multivariate regression analysis, the ADS was an independent risk factor for both aortic dilatation (>3.6 cm) and aortic plaque build-up (both, p < 0.001).
Conclusion
The ADS may be a risk factor for aortic dilatation and aortic atherosclerosis.
SampsonUKANormanPEFowkesGR. Global and regional burden of aortic dissection and aneurysms. Global Heart2014; 9: 171–180.
2.
CapocciaLRiambauV. Current evidence for thoracic aorta type B dissection management. Vascular2014; 22: 439–447.
3.
JiangHQiuXWangW. The position of the aorta changes with altered body position in single right thoracic adolescent idiopathic scoliosis: A magnetic resonance imaging study. Spine (Phila Pa 1976)2012; 37: E1054–1061.
4.
BeckerCRNikolaouKMudersM. Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT. Eur Radiol2003; 13: 2094–2098.
5.
BullmannVFallenbergEMMeierN. The position of the aorta relative to the spine before and after anterior instrumentation in right thoracic scoliosis. Spine (Phila Pa 1976)2006; 31: 1706–1713.
6.
LiuJShenJZhangJ. The position of the aorta relative to the spine for pedicle screw placement in the correction of idiopathic scoliosis. J Spinal Disord Tech2012; 25: E103–107.
7.
ChatzizisisYSCoskunAUJonasM. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: Molecular, cellular, and vascular behavior. J Am Coll Cardiol2007; 49: 2379–2393.
8.
VergalloRPapafaklisMIYonetsuT. Endothelial shear stress and coronary plaque characteristics in humans: Combined frequency-domain optical coherence tomography and computational fluid dynamics study. Circ Cardiovasc Imag2014; 7: 905–911.
9.
BradyARThompsonSGFowkesFG. Abdominal aortic aneurysm expansion: Risk factors and time intervals for surveillance. Circulation2004; 110: 16–21.
10.
BasnyatPSAionoSWarsiAA. Natural history of the ectatic aorta. Vascular2003; 11: 273–276.
11.
StatherPWDattaniNBownMJ. International variations in AAA screening. Eur J Vasc Endovasc Surg2013; 45: 231–234.
12.
WilminkABHubbardCSDayNE. The incidence of small abdominal aortic aneurysms and the change in normal infrarenal aortic diameter: Implications for screening. Eur J Vasc Endovasc Surg2001; 21: 165–170.
13.
von AllmenRSAnjumAPowellJT. Incidence of descending aortic pathology and evaluation of the impact of thoracic endovascular aortic repair: A population-based study in England and Wales from 1999 to 2010. Eur J Vasc Endovasc Surg2013; 45: 154–159.
14.
GolledgeJMullerJDaughertyA. Abdominal aortic aneurysm: Pathogenesis and implications for management. Arterioscler Thromb Vasc Biol2006; 26: 2605–2613.
15.
FreibergMSArnoldAMNewmanAB. Abdominal aortic aneurysms, increasing infrarenal aortic diameter, and risk of total mortality and incident cardiovascular disease events: 10-year follow-up data from the Cardiovascular Health Study. Circulation2008; 117: 1010–1017.
16.
OyamaNGonaPSaltonCJ. Differential impact of age, sex, and hypertension on aortic atherosclerosis: The Framingham Heart Study. Arterioscler Thromb Vasc Biol2008; 28: 155–159.
17.
HagerAKanzSKaemmererH. Coarctation Long-term Assessment (COALA): Significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material. J Thorac Cardiovasc Surg2007; 134: 738–745.
IsmailIAgarwalAAggarwalS. Aortic atherosclerosis: A common source of cerebral emboli, often overlooked!. Am J Therap2015.
20.
JollySSAmlaniSHamonM. Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: A systematic review and meta-analysis of randomized trials. Am Heart J2009; 157: 132–140.
21.
van der LindenJHadjinikolaouLBergmanP. Postoperative stroke in cardiac surgery is related to the location and extent of atherosclerotic disease in the ascending aorta. J Am Coll Cardiol2001; 38: 131–135.
22.
EggebrechtHSchmermundAVoigtlanderT. Risk of stroke after transcatheter aortic valve implantation (TAVI): A meta-analysis of 10,037 published patients. EuroIntervention2012; 8: 129–138.
23.
HaganPGNienaberCAIsselbacherEM. The International Registry of Acute Aortic Dissection (IRAD): New insights into an old disease. JAMA2000; 283: 897–903.
24.
RylskiBSuedkampMBeyersdorfF. Outcome after surgery for acute aortic dissection type A in patients over 70 years: Data analysis from the German Registry for Acute Aortic Dissection Type A (GERAADA). Eur J Cardiothorac Surg2011; 40: 435–440.
25.
Piechota-PolanczykADemyanetsSMittlboeckM. The influence of simvastatin on NGAL, matrix metalloproteinases and their tissue inhibitors in human intraluminal thrombus and abdominal aortic aneurysm tissue. Eur J Vasc Endovasc Surg2015; 49: 549–555.
26.
AulisaLPapaleoPPolaE. Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: A case-control study. Spine (Philia Pa 1976)2007; 32: 2700–2702.
27.
BurwellRGDangerfieldPHMoultonA. Whither the etiopathogenesis (and scoliogeny) of adolescent idiopathic scoliosis? Incorporating presentations on scoliogeny at the 2012 IRSSD and SRS meetings. Scoliosis2013; 8: 4.
28.
CaselliCDe GraafMALorenzoniV. HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain. Atherosclerosis2015; 241: 55–61.
29.
GoncalvesIBengtssonEColhounHM. Elevated plasma levels of MMP-12 are associated with atherosclerotic burden and symptomatic cardiovascular disease in subjects with type 2 diabetes. Arterioscler Thromb Vasc Biol2015.
30.
RossSEikelboomJAnandSS. Association of cyclooxygenase-2 genetic variant with cardiovascular disease. Eur Heart J2014; 35: 2242–2248a.
31.
YaprakMAltunAVardarA. Decreased nocturnal synthesis of melatonin in patients with coronary artery disease. Int J Cardiol2003; 89: 103–107.
32.
WolakT. Osteopontin - a multi-modal marker and mediator in atherosclerotic vascular disease. Atherosclerosis2014; 236: 327–337.
