Recently, endovascular treatment of coil embolisation has been widely used for obliterating cerebral aneurysms. However, the process of endothelial cell growth within aneurysms to prevent aneurysmal rupture associated with endovascular coil embolisation remains unclear. Fourteen aneurysms were produced in seven matured swine and embolised with Guglielmi Detachable coils (GDCs). The aneurysms were resected either immediately or three weeks after coil embolisation, and subjected to histological and scanning electron microscopic examinations. Blood coagulation factor XIII was administered in four animals on the day of embolisation and on the following four days. These aneurysms were also resected three weeks after the embolisation and investigated histologically. Marked fibroblast proliferation and growth of endothelial cells on the intraluminal surface of the coil were observed more often in the group administered factor XIII than in those not given factor XIII. These results suggest that administration of factor XIII may contribute to more effective aneurysm obliteration during coil embolisation.
GuglielmiGViñuelaF: Electrothrombosis of saccular aneurysm via endovascular approach; Part 1. J Neurosurg75: 1–7, 1991.
2.
GuglielmiGViñuelaF: Electrothrombosis of saccular aneurysm via endovascular approach; Part 2. J Neurosurg75: 8–14, 1991.
3.
GuglielmiGViñuelaF: Endovascular treatment of posterior circulation aneurysms by electrothrombosis using electrically detachable coils. J Neurosurg77: 515–524, 1992.
4.
MolyneuxAJEllisonDW: Histological findings in giant aneurysms treated with Guglielmi detachable coils. J Neurosurg83: 129–132, 1995.
5.
TenjinHFukuiS: Effect of Guglielmi detachable coils on experimental carotid artery in primates. Stroke26: 2027–2080, 1995.
6.
MawadMEMawadJK: Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils. Am J Neuroradiol16: 7–13, 1995.
7.
BavinzkyGTalazogluV: Gross and microscopic histpathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg91: 284–293, 1999.
HiraharaKShinboK: Suppressive effect of human blood coagulation factor XIII on the vascular permeability induced by anti-guinea pig endothelial cell antiserum in guinea pigs. Thromb Res71: 139–148, 1993.
10.
IsogaiNUedaY: Wound healing at the site of microvascular anastomosis; fibrin-stabilizing factor XIII administration and its effect. Microsurgery11: 40–46, 1990.
11.
KangYHashimotoN: Effects of blood coagulation factor XIII on the development of experimental cerebral aneurysms in rats. J Neurosurg73: 242–247, 1990.
12.
DawsonRCKrishtAF: Treatment of experimental aneurysms using collagen-coated microcoils. Neurosurgery36: 133–140, 1995.
13.
MurayamaYViñuelaF: Development of biologically active GDC for the treatment of cerebral aneurysms. Interventional Neuroradiology5: 211–214, 1999.
14.
TamataniSOzawaT: Radiologic and histopathologic evaluation of canine artery occlusion after collagen-coated platinum microcoil delivery. Am J Neuroradiol20: 541–545, 1999.
15.
MurayamaYViñuelaF: Ion implantation and protein coating of detachable coils for endovascular treatment of cerebral aneurysms: Concepts and preliminary results in swine models. Neurosurg40: 1233–1244, 1997.
16.
TamataniSOzawaT: Histological interaction of cultured endothelial cells and endovascular embolic materials coated with extracellular matrix. J Neurosurg86: 109–112, 1997.
17.
AhujaAAHergenrotherRW: Platinum coil coatings to increase thrombogenicity: A preliminary study in rabbits. Am J Neuroradiol14: 794–798, 1993.
18.
SzikoraIWakhlooAK: Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms. Am J Neuroradiol18: 67–672, 1997.
19.
KonishiYHalbachVV: Evaluation of acute thrombogenesis following microcoil aneurysm treatment in swine. Advances in Intravascular Radiology and Intravascular Neurosurgery: 45–50, 1996.
20.
ManabeHFujitaS: Rerupture of coil-embolized aneurysm during long-term observation. J Neurosurg88: 1096–1098, 1998.
21.
MiyachiSNegoroM: Histopathological study of balloon embolization; silicone versus latex. Neurosurg30: 483–489, 1992.
22.
MurayamaYViñuelaF: Development of the biologically active Guglielmi detachable coil for the treatment of cerebral aneurysms. Part II: An experimental study in a swine aneurysm model. Am J Neuroradiol20: 1992–1999, 1999.
23.
HorowitzMBBurnsPD: Scanning microscopic findings in a basilar tip aneurysm embolized with Guglielmi detachable coils. Am J Neuroradiol18: 688–690, 1997.
24.
SudaYKikuchiK: Long-term histopathology of intracranial aneurysms after endovascular treatment with coils. Interventional Neuroradiology5: 225–231, 1999.
25.
HayakawaMMurayamaY: Natural history of the neck remnant of a cerebral aneurysm treated with the Guglielmi detachable coil system. J Neurosurg93: 561–568, 2000.
26.
SpetzgerUReulJ: Microsurgically produced bifurcation aneurysms in a rabbit model for endovascular coil embolization. J Neurosurg85: 488–495, 1996.
27.
ShimizuSKurataA: Tissue response of a small saccular aneurysm after incomplete occlusion with a Guglielmi detachable coil. Am J Neuroradiol20: 546–548, 1999.
28.
CastroEForteaF: Long-term histopathologic findings in two cerebral aneurysms embolized with Guglielmi detachable coils. Am J Neuroradiol20: 549–552, 1999.
29.
ViñuelaFDockwilerG: Guglielmi detachable coil embolization of acute intracranial aneurysm: Perioperative anatomical and clinical outcome in 403 patients. J Neurosurg86: 475–482, 1997.
