Free accessResearch articleFirst published online 2015-3
Possible Role of the Microbiome in the Development of Acute Malnutrition and Implications for Food-Based Strategies to Prevent and Treat Acute Malnutrition
A pattern of changes in the microbiome composition have been observed in the normal maturation of the human gut. Perturbations from this pattern have been described in malnourished humans and reproduced in animal models of severe malnutrition. Treatment and prevention of malnutrition in the future may be more effective if the interventions not only restore body composition, but the composition of the microbiome as well.
YatsunenkoTReyFEManaryMJTrehanIDominguez-BelloMGContrerasMMagrisMHidalgoGBaldassanoRNAnokhinAPHeathACWarnerBReederJKuczynskiJCaporasoJGLozuponeCALauberCClementeJCKnightsDNightRGordonJI. Human gut microbiome viewed across age and geography. Nature2012;486:222–7.
2.
De FilippoCCavalieriDDi PaolaMRamazzottiMPoulletJBMassartSColliniSPieracciniGLionettiP. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA2010;107:14691–6.
3.
SmithMIYatsunenkoTManaryMJTrehanIMkakosyaRChengJKauALRichSSConcannonPMychaleckyjJCLiuJHouptELiJVHolmesENicholsonJKnightsDUrsellLKKnightRGordonJI. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013 Feb 1;339(6119):548–54.
4.
KauAPlanerJRaoSTrehanIManaryMHseihCSGordonJ. Immunoglobulin A targets microbes in the fecal microbiota of Malawian twins discordant for kwashiorkor. J Allergy Clin Immunol2013;131:(suppl):AB330.
