Background: Lifestyle medicine (LM) has been shown to reverse chronic diseases, yet data is limited on the application of LM interventions in low-resource countries. Methods: This practice-based implementation report evaluated the impact of individual and group LM interventions on chronic disease reversal in 15 patients followed longitudinally at a medical clinic in Malawi. Results: LM interventions led to the reversal of an average of 1.4 chronic diseases per patient based on legacy criteria used by the American Board of Lifestyle Medicine. Conclusion: These findings support the use of LM interventions for chronic disease reversal in a global health setting with limited resources. Future studies may explore enhanced health data tracking as well as expanding LM initiatives in similar environments.