Lifestyle medicine interventions are well established for the prevention and treatment of cardiovascular disease (CVD) and are increasingly applied to people with cancer, who face elevated cardiovascular risk from both the disease and its treatments. Cardio-oncology, an emerging subspecialty, focuses on prevention, management, and treatment of CVD in patients with cancer and survivors. Incorporating lifestyle medicine principles—such as physical activity, healthy diet, stress management, and social connections—can help mitigate CVD risk in this population. This article reviews the impact of cancer and its therapies on cardiovascular health, current guideline recommendations, and the importance of an interprofessional, holistic approach to individualized care.
HivertMFArenaRFormanDE, et al.Medical training to achieve competency in lifestyle counseling: an essential foundation for prevention and treatment of cardiovascular diseases and other chronic medical conditions: a scientific statement from the American heart association. Circulation. 2016;134(15):e308-e327. doi:10.1161/CIR.0000000000000442
OgilvieLMCoyle-AsbilBBruntKRPetrikJSimpsonJA. Therapy-naïve malignancy causes cardiovascular disease: a state-of-the-art cardio-oncology perspective. Am J Physiol Heart Circ Physiol. 2024;326(6):H1515-H1537. doi:10.1152/ajpheart.00795.2023
4.
MillsteinRAWintersLSullivanCEisenstatSSorgEComanderA. Implementing a multidisciplinary lifestyle medicine clinic for cancer survivorship. Oncology (Williston Park). 2024;38(11):421-425. doi:10.46883/2024.25921030
5.
StrongmanHGaddSMatthewsA, et al.Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394(10203):1041-1054. doi:10.1016/S0140-6736(19)31674-5
6.
HeDQinKLiJ, et al.Increased incidence risks of cardiovascular disease among cancer patients: evidence from a population-based cohort study in China. Int J Cardiol. 2024;396:131362. doi:10.1016/j.ijcard.2023.131362
BloomMWVoJBRodgersJE, et al.Cardio-oncology and heart failure: a scientific statement from the heart failure society of America. J Card Fail. 2025;31(2):415-455. doi:10.1016/j.cardfail.2024.08.045
MisiągWPiszczykASzymańska-ChabowskaAChabowskiM. Physical activity and cancer care-A review. Cancers (Basel). 2022;14(17):4154. doi:10.3390/cancers14174154. Published 2022 Aug 27.
LowyDRFioreMCWillisGMangoldKNBlochMHBakerTB. Treating smoking in cancer patients: an essential component of cancer care-the New National cancer institute tobacco control monograph. JCO Oncol Pract. 2022;18(12):e1971-e1976. doi:10.1200/OP.22.00385
13.
LeeHJiangCBhattDLKimHCLeeH. Smoking habits following cancer diagnosis and heart failure. JAMA Netw Open. 2024;7(10):e2437867. doi:10.1001/jamanetworkopen.2024.37867
14.
ParkERPerezGKReganS, et al.Effect of sustained smoking cessation counseling and provision of medication vs shorter-term counseling and medication advice on smoking abstinence in patients recently diagnosed with cancer: a randomized clinical trial. JAMA. 2020;324(14):1406-1418. doi:10.1001/jama.2020.14581
15.
NongJTongJWangRShiKZhangY. Associations of sleep disorders with all-cause and cause-specific mortality in cancer survivors: a cross-sectional analysis of the NHANES 2005-2016. BMC Psychiatry. 2024;24(1):118. doi:10.1186/s12888-024-05589-3. Published 2024 Feb 12.
16.
BoenCEBarrowDABensenJT, et al.Social relationships, inflammation, and cancer survival. Cancer Epidemiol Biomarkers Prev. 2018;27(5):541-549. doi:10.1158/1055-9965.EPI-17-0836
17.
AlbasheerOAbdelwahabSIZainoMR, et al.The impact of social isolation and loneliness on cardiovascular disease risk factors: a systematic review, meta-analysis, and bibliometric investigation. Sci Rep. 2024;14(1):12871. doi:10.1038/s41598-024-63528-4. Published 2024 Jun 4.
18.
Vignjević PetrinovićSMiloševićMSMarkovićDMomčilovićS. Interplay between stress and cancer-A focus on inflammation. Front Physiol. 2023;14:1119095. doi:10.3389/fphys.2023.1119095. Published 2023 Mar 20.
19.
BerishaAShutkindKBornigerJC. Sleep disruption and cancer: chicken or the egg?Front Neurosci. 2022;16:856235. doi:10.3389/fnins.2022.856235. Published 2022 May 19.
20.
MuddTWJrKhalidMGuddatiAK. Cardiotoxicity of chemotherapy and targeted agents. Am J Cancer Res. 2021;11(4):1132-1147. Published 2021 Apr 15.
21.
MehtaLSWatsonKEBaracA, et al.Cardiovascular disease and breast cancer: where these entities intersect: a scientific statement from the American heart association. Circulation. 2018;137(8):e30-e66. doi:10.1161/CIR.0000000000000556
22.
FradleyMGNguyenNHKMadnickD, et al.Adverse cardiovascular events associated with cyclin-dependent kinase 4/6 inhibitors in patients with metastatic breast cancer. J Am Heart Assoc. 2023;12(12):e029361. doi:10.1161/JAHA.123.029361
