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Abstract

The purpose of this review is to provide health practitioners and physicians the most current state of the research on sarcopenia, its consequences, and to offer a summary of consensus guidelines for identification based on the most recent and compelling investigations and analyses. To accomplish this, the causes and consequences of sarcopenia will be described, and definitions and screening methods are updated. Importantly, interventional recommendations for sarcopenia will be discussed with a special emphasis on the effects of resistance training on sarcopenia-related outcomes. Furthermore, due to the increasing usage of hormone treatment as a strategy to combat sarcopenia, special consideration on the effects of hormone changes with aging and as interventions will be briefly reviewed.

Keywords

aging muscle strength function

‘Sarcopenia is defined in the literal sense from the Greek for “poverty of the flesh” and is the natural, aging-related process of the loss of LM [lean mass]’

The aging process in the growing population of older adults is accompanied by an increase in chronic health conditions and a high prevalence of functional limitations and disability associated with declines in lean mass (LM; ie, sarcopenia) and strength.¹ Healthy People 2020 estimates that more than 37 million older adults are expected to be managing at least one chronic disease or condition by the year 2030.² The economic burden associated with disability in older adults remains high³ despite small annual declines in chronic disability attributed to improved overall health. Nevertheless, health care costs associated with sarcopenia-related disability in the year 2000 were estimated to be $12.6 billion for older men and $29.5 billion for older women.⁴ Moreover, given the rapid increase in the older adult population over the past 15 years, these estimates are now likely to be far higher.

Lifestyle changes that are associated with aging include a reduction in physical activity levels,⁵ which is related to a multitude of complex aging-related changes that affect muscle and physical functioning in older adults.^6,7 As a result, determining who is at risk and what the best interventions are to improve LM and function and/or to prevent LM loss and disability is a critical public health objective.^8,9 Accordingly, there has been a rapid growth in the scientific literature over the past several years investigating sarcopenia and related health outcomes. For example, as of February 2015, a PubMed search using the term “sarcopenia” yielded >2800 results, with >2000 of these published in the past 5 years. However, the most valid methods to identify sarcopenic patients and to determine recommendations for interventions that best reduce declines in physical functioning remain elusive. Therefore, recent research has focused on currently unanswered questions of how to recognize and treat patients living with sarcopenia, and excellent systematic and scholarly reviews of the sarcopenia literature have been recently performed.^1,10-15

What Is Sarcopenia, and Why Is It Important to Clinicians?

Sarcopenia is defined in the literal sense from the Greek for “poverty of the flesh” and is the natural, aging-related process of the loss of LM. Skeletal muscle undergoes numerous changes during adult aging including fiber atrophy, loss of type II muscle fibers, clustering of type I fibers, a reduction in fast motor units, fatty infiltration, and neuromuscular changes that all may contribute to the process of sarcopenia.^6,16 Thus, sarcopenia is a multifactorial geriatric syndrome¹⁷ and was first mentioned in the literature as a condition by Rosenberg¹⁸ over 25 years ago. The loss of LM is considered a universal hallmark of the aging process, especially later in life, and sarcopenia is viewed as a chronic state that is distinct from other conditions of LM loss such as microgravity exposure, wasting, cachexia, and other chronic conditions or muscle diseases.¹⁵ Sarcopenia is closely associated with reductions in muscle strength and power,^19,20 physical function,^21-23 and increased risk of disability in older adults.⁸

Estimates of sarcopenia prevalence vary,^24,25 and the national estimates have historically been hampered by unclear definitions or cut-points due to a lack of strong clinical end-points. A recent meta-analysis suggests¹³ that among a host of different age groups and sarcopenia identification techniques sarcopenia prevalence can be anywhere from 1% to 29% in community-dwelling older adults, 14% to 33% in older adults in long-term care facilities, and ~10% in acute care facilities. Irrespective of the wide ranging estimates, sarcopenia and associated symptoms are considered major public health problems given their strong associations with numerous outcomes including reductions in strength,²⁶ physical functioning,²⁷ increased hospitalization risks,²⁸ postoperative complications,²⁹ and mortality.³⁰ Consequently, clinicians and researchers often refer to sarcopenia more as a process rather than a specific clinical diagnosis, and attempts to define sarcopenia typically employ appendicular LM (ALM) cut-points, either compared to younger adult reference groups³¹ or as the lowest percentile of an older cohort.²⁷ Importantly, for the purposes of the current review, it is essential to note at this time that the use of LM and ALM refers specifically to muscle mass and does not include bone mass.

Challenges to Diagnosing Sarcopenia

There have been numerous attempts to identify a viable algorithm to classify sarcopenic individuals, and the major obstacle to such a universally accepted definition has been the lack of strong clinical end-points and clinically independent predictors of sarcopenia (eg, the use of fracture risk for osteoporosis).¹⁴ Some have made a convincing arguments that sarcopenia, often used as a broad term for decreased muscle function associated with LM losses, should become a specific diagnosis that should apply only to LM losses with age, and that dynapenia should be used when describing the age-related loss of muscle strength.³² The powerful relationship between LM and muscle function previously hypothesized by investigators has been reexamined and are now considered interrelated but separate conditions as the notion of “sarcopenia with impaired mobility”¹⁵ is a more apt classification. Nevertheless, sarcopenia seems to be the most recognized term and remains the primary focus of recent investigations, although the model for using measures of physical and muscular function as primary criteria for sarcopenia identification in an individual has gained considerable traction.

Arguably, the most commonly employed method for sarcopenia determination has been the use of the skeletal muscle index (SMI), which is equal to the quotient of a person’s ALM divided by his/her height-squared (ALM/height²). The advantage of this method is that it considers the height of the individual as taller people tend to have more LM.³³ Indeed, the highly recognized New Mexico Elders Aging Process Study used the SMI with sex-specific standard deviation cut-points for comparison to a younger reference population from the Rosetta Study.³¹ However, there were 2 major obstacles that prevented this from becoming the accepted definition. First, the SMI did not account for body fat mass and seemed to only classify people with low body mass index (BMI) as sarcopenic. For example, when the SMI method was applied to the Health, Aging and Body Composition (Health ABC) cohort, a longitudinal study of 3075 community-dwelling older men and women, no obese participant was classified as sarcopenic.²⁷ It is now well documented that body fat mass can adversely affect mobility,³⁴ and because the SMI resembles the definition for BMI, it excludes some older adults with relatively low LM and high fat mass from being classified as sarcopenic. A second major limitation to the SMI method is the lack of physical function measurement as part of the definition. While LM and strength are correlated,²⁶ there are a host of other factors that influence muscle function that cannot be ignored (Figure 1).

Figure 1.

A Working Model by Clark and Manini⁷ of the Hypothesized Etiologic Factors That Are Responsible for the Development of Dynapenia in Older Adults.

In response to the SMI misidentifying some older individuals as normal who may have “sarcopenic obesity,” alternative methods were developed to better categorize persons who have relatively poor physical function and mobility due to low LM relative to body fat mass. Furthermore, although consensus guidelines vary in terms of cut-points for sarcopenia screening, there now seems to be some agreement that the key elements for defining sarcopenia are (a) poor physical functioning, (b) muscle weakness, and (c) low LM. Accordingly, these criteria should be examined together further to determine an individual’s sarcopenic status and also additional health-related factors to consider when evaluating treatment options.

Functional Outcomes

There are several simple, valid, and reliable ways to measure physical function in older adults involving tests for balance, chair rising (standing from a seated position), and walking (eg, Short Physical Performance Battery).³⁵ Most functional tests include some measure of gait speed and typically employ the 6-minute walk, 400-meter walk, and/or timed up-and-go tests.³⁶ The importance of gait speed for daily activities and inclusion in the definition of sarcopenia cannot be understated as gait speed is associated with a myriad of health outcomes including overall physical functioning, executive function,³⁷ and mortality risk.³⁸ In addition, gait speed is one of the defining criteria for frailty,³⁹ which is a broader health concept that may include sarcopenia and related conditions.¹⁷ For example, walking speed predicts survival and increases in gait speed as little as 0.1 m/s significantly improve survival likelihood.³⁸ Additionally, to emphasize this importance, some have suggested that gait speed should be assessed clinically with breathing, temperature, heart rate, pain, and color and become the “sixth vital sign.”⁴⁰ Appropriately, a gait speed cut-point of <0.8 m/s is now used as part of the differential diagnosis for sarcopenia in at least 2 novel definitions.^14,17

Muscle Function

Muscle strength is considered a component of physical fitness and muscle weakness is associated with poor physical functioning^41,42 and an increased risk for metabolic disease,⁴³ hospitalization,²⁸ and mortality³⁰ in older adults. Peak strength typically plateaus sometime in the 30s followed by a steady decline thereafter, and the age-associated loss of muscle strength that is not caused by neurologic or muscular disease is referred to as dynapenia.^19,44 Nevertheless, like sarcopenia, dynapenia is a complex process and appears to increase in severity during the seventh decade.^12,31 In addition, the direct effects of sarcopenia on functional outcomes may be best illustrated by the dramatic 30% declines in competitive international weightlifting records observed in men between 30 and 60 years⁴⁵ (Figure 2). Furthermore, this relationship seems to be associated with a stepwise strength decrease beginning in the fourth decade, which continues into the seventh decade at which point women appear to retain only ~30% of the strength formerly possessed in their 30s⁴⁵ (Figure 2).

Figure 2.

Average National and International Masters Level Men’s and Women’s Combined Total Weightlifting Records Are Presented From Competition Results of the USA National, Pan American, and American Masters Competition Weightlifting Events Occurring Between August 1, 2014 and February 20, 2015.

Recent findings from the Health ABC study²⁶ confirm that over a 5-year period muscle strength declines at a much faster rate than muscle cross-sectional area (CSA), suggesting reduction in muscle quality (force production per unit area of LM) (Figure 3). In a 5-year study of 1678 participants, men and women exhibited decreases in knee extensor muscle torque by 16.1% and 13.4%, respectively. These losses amount to an annualized decrease in knee torque that is 2 to 5 times greater than the decreases in leg muscle CSA. Interestingly, although some participants gained weight and increased muscle CSA over the 5-year period, torque loss was similar to overall group change, despite increases in contractile tissue. These greater age-related decrements in strength compared to muscle CSA indicate a loss in muscle quality, further illustrating that LM is not the sole determinant of muscle strength or function in older adults.²⁶

Figure 3.

Five-Year Percentage Changes in Mid-Thigh Muscle Cross-Sectional Area (CSA), Knee Extensor Torque, and Muscle Quality (Torque Divided by CSA) in 1678 men and women from the Health, Aging and Body Composition Study.

In addition, it should be noted that muscle power is a measure of the rate of performing mechanical work and explains variance in physical function in older adults better than measures of strength alone.^46,47 Power has been shown to decrease roughly 3% to 4% faster than strength,^19,48,49 with aging and power declines earlier in women when compared to men.¹⁹ Furthermore, muscle power in older adults is associated with worsened muscle structure, function, tendon characteristics, and increased sarcopenia in specific muscle groups.⁵⁰ In fact, some age comparisons¹⁹ suggest that a decrease of >50% in muscle power occurs between the ages of 20 and 80 years without substantial differences in muscle CSA, which further suggests that muscle power declines are a consequence of causes other than LM.

In most studies, muscle strength is more strongly associated with low physical function compared to LM in older adults, which further supports the evidence for uncoupling of muscle strength and LM with age (ie, declines in muscle quality). Based on their findings, Manini and Clark⁷ have further suggested that screening for dynapenia is a more important clinical outcome rather than, or at least in addition to, LM (Figure 1). Despite the mounting evidence sarcopenia is still considered a more commonly recognized condition and the introduction of a new diagnosis (ie, dynapenia) might result in misunderstandings for clinicians and patients.¹⁷

Lean Mass

The definition of sarcopenia began as a description of LM losses, and LM continues to be at least partly responsible for decreased strength and function in older adults. Therefore, it is essential for evidence-based reasons and consistency purposes to include LM in an operational definition of sarcopenia. In community-dwelling men and women in their 70s, low muscle CSA is related with lower physical function.⁵¹ Longitudinal data from the Health ABC Study²⁶ also suggest that men and women in their 70s experience 5-year mid-thigh LM losses of ~5% in men and ~3% in women and a dramatic increases of intermuscular fat infiltration (~49% in men, ~29% in women), indicating specific changes in regional body composition with aging. Moreover, low-thigh muscle CSA increases the risk of major disability by ~40%.⁴¹

Body fat mass is a strong predictor of physical function, particularly in women who seem to be more susceptible to sarcopenia and its consequences. Indeed, Riebe et al³⁴ observed in the Study of Exercise and Nutrition in Older Rhode Islanders investigation that obese older women have lower physical function scores, determined by gait speed, compared with obese older men and therefore are at increased risk for future mobility impairment. Likewise, older women have reduced physical function compared with men, which is explained primarily by higher fat mass.⁵² Furthermore, higher body fat mass and/or higher fat mass to LM ratios may lead to biomechanical disadvantages in women and increased effort with movement. Accordingly, data seem to support the inclusion of fat mass measurement when evaluating individuals for sarcopenia.

Measuring Lean Mass

Computed tomography (CT) and magnetic resonance imaging (MRI)⁵³ are best for measuring ALM, but these techniques are expensive, are typically restricted to well-funded research studies¹⁷ or clinics, and include exposure to radiation (CT). Bioelectrical impedance analysis (BIA) is an alternative and inexpensive technique for measuring total body LM, and hand-held and bathroom scale–type devices are easy to use and common. Subsequently, total body LM measured via BIA is employed frequently in research and has been included in some sarcopenia definitions that utilize total body LM.¹⁷ Unfortunately, inexpensive BIA devices are unable to identify specific regional sites (ie, ALM). Newly developed, advanced, multifrequency BIA devices can measure ALM,⁵⁴ but the higher costs and the relatively low prevalence may limit their utility. Consequently, dual energy X-ray absorptiometry (DXA) continues to be accepted as the clinical “gold standard” for body composition assessment. Bone density in the aging population is routinely examined using DXA,¹⁵ and increased use in both clinical and research settings has resulted in regional LM estimates for increased numbers of older adults. However, more work is necessary to improve LM databases for specific gender age ranges and racial/ethnic groups.¹⁴

Moving Toward a Sarcopenia Definition Consensus

Without a universally accepted definition for sarcopenia, most studies could not effectively screen participants for sarcopenia and/or used definitions based on preference and available measures for LM, and thus interpreting or comparing results has been a challenge. Accordingly, several “working groups” have convened to establish consensus and progress has been made toward a definition of sarcopenia. The most prominent statements have been from the European Working Group on Sarcopenia in Older People (EWGSOP), the International Working Group (IWG), and the Foundation for the National Institutes of Health Sarcopenia Project (FNIHSP).

EWGSOP Guidelines

The EWGSOP developed a classification method to identify individuals based on clinical symptoms associated with sarcopenia rather than LM alone¹⁷ (Table 1). Moreover, given the known and unknown causes of sarcopenia, the EGWSOP determined that sarcopenia should be described as “primary,” the natural multifactorial age-related decline in LM, or “secondary” due to one or more identifiable causes such as chronic inactivity, other diseases, or specific dietary factors.¹⁷ Thus, the EWGSOP’s algorithm for screening for sarcopenia includes gait speed and grip strength as primary criteria, and LM is only considered in the presence of low gait or grip scores.¹⁷ A classification system to grade sarcopenia for tracking those with varying degrees of sarcopenia was also developed. Essentially, this novel classification system recognizes that primary sarcopenia typically develops over a long period and therefore EWGSOP established sarcopenia stages¹⁷ (ie, presarcopenia, sarcopenia, and severe sarcopenia), similar to those adopted for osteoporosis⁵⁵ or hypertension,⁵⁶ with presarcopenia defined as the presence of low LM only.

Table 1.

The European Working Group on Sarcopenia in Older People Sarcopenia (EWGSOP) and International Working Group on Sarcopenia (IWG) Screening Guidelines for Sarcopenia and Severe Sarcopenia^a.

Presarcopenia	EWGSOP	IWG
Lean mass, ALM/height²
Men	<7.23 kg/m²	N/A
Women	<5.67 kg/m²	N/A
Sarcopenia
Gait speed	<0.8 m/s	<1.0 m/s
Muscle strength^b	OR
Men	<30 kg	N/A^c
Women	<20 kg	N/A^c
Lean mass, ALM/height²	AND
Men	<7.23 kg/m²	<7.23 kg/m²
Women	<5.67 kg/m²	<5.67 kg/m²
Severe sarcopenia
Gait speed	<0.8 m/s	N/A
Muscle strength^a	AND
Men	<30 kg	N/A
Women	<20 kg	N/A
Lean mass, ALM/height²	AND
Men	<7.23 kg/m²	N/A
Women	<5.67 kg/m²	N/A

Abbreviation: ALM, appendicular lean mass.

Adapted from Cruz-Jentoft et al,¹⁷ Dam et al,⁵⁷ and Fielding et al.¹⁵

Measured by grip strength.

The IWG suggests a single chair rise test as a potential measure of lower body strength.

IWG Guidelines

Concurrently, the IWG, a team of scientists and geriatricians from both academia and the private sector, proposed a somewhat similar set of criteria¹⁵ (Table 1). While the IWG similarly included gait speed, cut-points were less conservative (<1.0 m/s) than EWGSOP guidelines. The IWG did not specify a measure or cut-point for muscle strength, but they suggest that the ability to rise from a chair unassisted should be used as an indicator of lower-body physical function. Importantly, this test assesses lower body function adjusted automatically for total body mass and, in our opinion, was a strong choice. The need to screen for LM using the IWG system is predicated on a mobility deficiency and suggests that the sex-specific SMI cut-points be used.¹⁵ Although these (or similar) LM cut-points have been used in other sarcopenia definitions,^27,31 there seems to be no recommendation for adjustments for fat mass or BMI, and therefore the use of LM-only cut-points may diminish the ability to identify those with sarcopenic obesity.²⁷

The definitions of sarcopenia developed by the EWGSOP and IWG employ a combination of mobility and strength with LM, but the use of absolute sex-specific LM cut-points that do not account for fat mass, which has considerable interindividual variability and is a major predictor of function in sarcopenic individuals,^27,34,58 may not be optimal.

How Do These New Definitions Compare?

The EGWSOP and IWG guidelines for sarcopenia identification were not tested, per se, at the time of their adoption, and analyses have been conducted post hoc to examine their clinical validity.

Alley et al⁵⁹ examined the combined study pool and suggested a clinical “weak” cut-point of <26 kg in men and <16 kg for women, as these cut-points are associated with a ~7.6- and ~4.4-fold greater risk of mobility impairment, respectively, when compared to normal strength men and women. Additionally, they established an “intermediate” range for grip strength of 26 to 32 kg and 16 to 20 kg for men and women that were associated with a ~3.6- and ~2.4-fold increased mobility risk, respectively. Together, a much higher percentage of women (18%) in this cohort were identified as “weak” compared with men (5%), which reinforces previous findings that women may be more susceptible to dynapenia. Grip strength measures were further adjusted for BMI, and in women seemed to be a better predictor of mobility impairment compared with absolute strength. However, these differences were not substantial enough to recommend the further use of BMI adjusted values.

In a follow-up study, Cawthon et al⁶⁰ established cut-points for low LM that correspond to weakness. Low ALM levels in men were found to be <19.75 kg and <15.02 kg in women, and were associated with an increased risk of weakness when compared with normal men (odds ratio [OR] = 6.9, 95% confidence interval [CI] = 5.4, 8.9) and women (OR = 3.6, 95% CI = 2.9, 4.3). Furthermore, ALM was an independent predictor of mobility in men with a 2- to 4.5-fold greater risk of mobility limitation in men with low ALM, but only muscle strength independently predicted gait speed in women. In addition to absolute LM cut-points, an adjustment for BMI was made to the ALM cut-points (ie, ALM/BMI; “ALM_BMI”), and these low ALM_BMI cut-points (men = 0.789, women = 0.512) corresponded to a higher risk of weakness in men (OR = 4.3, 95% CI = 3.4, 5.5) and women (OR = 2.2, 95% CI = 1.8, 2.8) compared with their normal-strength counterparts. Not surprisingly, using this metric, the prevalence of weakness in women at this cut-point was 31% while only ~12% in men. Interestingly, those women whose ALM_BMI was ≥0.512 (ie, higher LM) there was a strong influence of BMI as the prevalence of weakness in women who had a BMI of <23.7 kg/m² was only 12% while the weakness prevalence rose to over 24% in women with a BMI >23.7 kg/m². These findings support previous study evidence⁵⁸ suggesting that body fat mass mediates the relationship between LM, strength, and mobility in older women.⁶⁰ Finally, these data are supported by other FNIHSP analyses⁶¹ that show that these sex-specific cut-points for grip strength and ALM_BMI, but not absolute ALM, are independent predictors of incident mobility impairment in men and women.

The FNIHSP recommends that individuals should be identified using either “weak with low LM” or “weak and slow with low LM” rather than using the term sarcopenia. The overall FNIHSP recommendations for cut-points in identifying sarcopenia in older adults are shown in Table 2. The FNIHSP concurs with the EWGSOP and IWG on the use of <0.8 m/s for a gait speed cut-point as this is an easy measure to obtain in most settings and is a strong predictor of major health outcomes.³⁸

Table 2.

The Foundation for the National Institutes of Health Sarcopenia Project Recommended Modalities and Cut-Points for Identifying Functional Limitation, Muscle Weakness, and Low Lean Mass in Older Men and Women^a.

	Cut-Point for Men	Cut-Point for Women
Weakness with low lean mass
Gait speed	—	—
Muscle strength: grip strength	<26 kg	<16 kg
Lean mass: ALM_BMI	<0.789	<0.512
Weakness and slowness with low lean mass
Gait speed	<0.8 m/s	<0.8 m/s
Weakness	<26 kg	<16 kg
Lean mass: ALM_BMI	<0.789	<0.512

Abbreviations: ALM, appendicular lean mass; BMI, body mass index; ALM_BMI, ALM divided by BMI.

Adapted from Studenski et al.¹⁴

What Can Be Done to Improve Lean Mass and Function in Sarcopenic Adults?

Establishing successful intervention strategies that preserve and/or improve LM and function is crucial. There has been a significant effort to determine the most effective and efficacious interventions for treating sarcopenia and its associated symptoms. The primary focus of current research includes diet and dietary supplementation, hormone therapies, physical activity programs, and resistance training (RT).¹³ Indeed, Fragala and colleagues investigated the combined effect of vitamin D with physical activity, fish oil supplementation, DHEA, or 17-β-estradiol therapy on physical and muscle function and LM based on FNIHSP cut-points in women (n = 378) who were weak and had low LM versus women who were considered normal and reported that muscle weakness, a primary symptom of sarcopenia in the FNIHSP definition, can be improved in low-functioning older women.⁶² Furthermore, results suggest that weaker female participants respond more favorably to interventions with regard to strength, and interestingly, women with higher LM respond better. However, although well designed and executed, this analysis combined different intervention modes, and the individual impact of each cannot be assessed. Therefore, a brief overview of dietary/supplementation, hormonal therapies, and physical activity interventions independently is important.

Protein Intake

It has been suggested that up to 38% of adult men and 41% of adult women have dietary protein intakes below the recommended daily allowance (RDA).⁶³ The Food and Nutrition Board of the United States National Academy of Science recommends 0.8 g protein/kg/day for all adults. This value represents a minimum amount of protein required to avoid progressive loss of LM in most healthy individuals, which may not apply to the aging population.^64-66 Some investigations suggest this protein RDA may actually be insufficient to maintain LM, not to mention recover what has been lost to decades of aging.^63,64,66 In addition, some research suggests that the efficiency of protein utilization is degraded with aging and results in blunted muscle protein synthesis, and decreases in dietary protein intake further facilitates sarcopenia by promoting an internal environment of net muscle protein catabolism and loss. Indeed, in older individuals who perform RT, increases in LM occur principally in those consuming 50% more protein per day than is currently recommended.^64,67-69

Historically, clinicians and research investigators were hesitant to recommend high-protein diets for older adults due to concerns of the potential harmful effects on bone health and renal, neurological, and cardiovascular function.^65,70 However, further investigations of high-protein diets in elderly participants suggest that many of these factors are actually improved.^66,71-77 In addition, the promising observation that muscle protein synthesis increases in response to protein or amino acid ingestion^78-80 in older participants similar to younger adults^63,78-80 without a compensatory change in muscle protein breakdown was recently reported. Unfortunately, dietary protein intake is reduced with aging and this relationship is multifactorial and includes increased expense, satiety, dentition/chewing difficulties, and/or changes in digestion, gastric emptying, and peristaltic dysrhythmias.⁶³ In response, amino acid supplementation to combat reduced caloric and protein intake in the aging population has been suggested. However, it appears that complex nutritional supplements are required beyond simple amino acid tablets and the development of novel easily ingestible and digestible protein supplements may be required to meet the anabolic demands of skeletal muscle for protein in the elderly. Regardless, there is currently insufficient longitudinal research to identify an ideal value for daily protein requirements or to elucidate the benefits of dietary protein on sarcopenia-related conditions.^65,66,81 It should be noted that kidney function decreases with age, high protein intake is contraindicated in individuals with renal disease, and assessment of renal function is recommended for older individuals before they adopt a higher protein diet.⁷⁰

In addition, there is evidence that novel dietary supplements may be efficacious in treating sarcopenia and include creatine and β-hydroxy-β-methylbutyrate (HMB).⁸² Creatine has been widely studied as an ergogenic aid for its muscular performance improvements,⁸³ and there is evidence⁸⁴ that creatine supplementation may have additive beneficial effects with RT for increasing LM, muscle strength and function, but not all studies agree.^85,86 The effects of combining dietary HMB, arginine, and lysine was investigated in 40 older adults (age = 76 ± 1.6 years)⁸⁷ and significant improvements in LM after 1 year were reported, and participants who received the treatment combination and who also had low vitamin D levels initially exhibited improved muscle strength. Additionally, HMB supplementation maintains LM in adults in their late 60s during 10 days of bed rest.⁸⁸ Despite some promising results of creatine and HMB as potential treatments for low LM and strength in older adults, data are sparse and further investigation is warranted to determine the benefits of nutritional and supplemental dietary interventions for age-related losses of LM and function.

A Brief Update on Hormone Replacement Therapy

An increasing number of clinical trials have been performed evaluating the efficacy of hormones such as testosterone, growth hormone, insulin-like growth factor, dehydroepiandrosterone, estrogen, and estradiol, with conflicting results. Therefore, while there is great interest in discovering a pharmacotherapeutic treatment for sarcopenia, there has not been a consensus demonstrating the efficacy for hormone replacement therapy (HRT) for the treatment of sarcopenia as studies tend toward mixed results. Furthermore, there are indications for possible adverse clinical outcomes with HRT in older adults including diabetes and glucose intolerance,⁸⁹ breast cancer,⁹⁰ coronary artery disease,⁹¹ stroke,⁹² and all-cause mortality.^93,94 A complete review of the rich literature on this topic is beyond the scope of this article, but due to the increasing usage of testosterone and estrogen replacement, we offer a brief summary of HRT as a treatment for sarcopenia.

Testosterone Replacement Therapy

Production of testosterone and serum testosterone concentrations decline as men age and it appears that androgens determine LM maintenance in older men.^95-97 Indeed, hypogonadism, or the low serum concentration of testosterone, is associated with LM and strength loss.^98,99 Interestingly, declines in circulating androgens seem to parallel the myofiber degradation and muscular strength declines in older men. Some reports suggest that the incidence of low total serum testosterone (<325 ng/dL) is 20% for men in their 60s, 30% for men in their 70s, and 50% for men over 80 years.^100,101 It was observed in another investigation that 12.3% of men aged 40 to 70 years have a total serum testosterone of <200 ng/dL with 3 or more symptoms of hypogonadism.¹⁰² Another study suggests that the adjusted mortality risk in men over 40 years with low testosterone is increased by 88%.⁹³ Interestingly, muscular declines also begin in the fourth decade and are associated with dramatic changes in body composition (LM declines and the mass of adipose tissue expands), which form the basis of many metabolic disorders ultimately resulting in an increased incidence of morbidity and mortality.¹⁹

Within this population, testosterone administration dose-dependently improves LM, and some studies have reported substantial increases in muscle strength^98,103,104 while others have reported only modest increases.^105,106 Studies reporting more substantial effects of testosterone replacement therapy (TRT) administer testosterone at higher than physiologic replacement dosages and administered via intramuscular injection.^103,104 Collectively, research suggests that the beneficial effects of TRT for the treatment of sarcopenia involve multiple signal transduction pathways, and currently it seems that testosterone reverses sarcopenia in older hypogonadal men through stimulation of cellular metabolism and survival pathways together with the inhibition of muscle cell apoptosis and suppression of age-specific increases in oxidative stress.¹⁰⁷ Clinically, Bhasin et al demonstrated that LM and strength are substantially increased by a very high dose of testosterone¹⁰⁸ without adverse events, and combined, research suggests that modest enhancement of muscle can be expected with physiologic replacement TRT doses, whereas higher-than-replacement dosages are required for more robust improvement in musculoskeletal gains and adipose reduction^109,110; however, concerns about TRT exist.

A recent meta-analysis suggests that the primary risk of adverse events in response to TRT include polycythemia, a small reduction in high-density lipoprotein cholesterol (HDL-C), and an increased urinary symptoms, benign prostatic hyperplasia, and prostate cancer.^111-113 In contrast, another meta-analysis observed no significant evidence of increased prostate cancer in response to TRT.¹¹¹ Nevertheless, TRT is being employed at a swiftly increasing rate in the United States, with sales in 2011 reaching $1.6 billion.¹¹⁴ Studies investigating the combined effects of TRT and the pharmacologic inhibition of the testosterone to dihydrotestosterone conversion have been employed to determine if benefits of TRT can be achieved without the risk of adverse prostatic events. One investigation suggested that older hypogonadal men treated with high-dose testosterone and finasteride experienced increases in physical performance and grip strength while suppressing adiponectin and lowering low-density lipoprotein cholesterol (LDL-C) without affecting HDL-C or the prostate.^115,116 Moreover, Borst et al, when investigating the effects of intramuscular injection of higher than replacement dose testosterone combined with finasteride treatment for 1 year, observed significant increases in LM and muscle strength and reductions in body fat without prostate enlargement.⁹⁸

Unfortunately, similar to investigations of sarcopenia, studying the health risks associated with untreated hypogonadism is often limited by study design variation and the lack of longitudinal research, randomized controlled investigations, and universally accepted diagnostic criteria.¹¹⁷ Nevertheless, until a scientific and clinical consensus can be reached, further investigation of the risks and/or benefits of TRT in men with hypogonadism and sarcopenia is essential.

Estrogen Replacement Therapy

Women experience changes in sex hormones (ie, estrogen and progesterone) a decade or more prior to menopause, and because the life expectancy of females may typically exceed 80 years, it is reasonable to suggest that a woman will spend nearly one third of her life in a sex-hormone-deficient state.¹¹⁸ Initially there is a significant decline in inhibin B and an increase in follicle-stimulating hormone followed by declines in inhibin A and estrogen.¹¹⁹ Consequently, concentrations of estrogen in an older woman can be half that observed before menopause.¹¹⁹ During the transition from pre- to postmenopause and thereafter, women without estrogen replacement therapy (ERT) exhibit increased incidence of osteopenia and osteoporosis, central and visceral adiposity, insulin resistance, dyslipidemia, sarcopenia, and frailty.¹²⁰ Indeed, positive relationships between LM and estrogen and/or estradiol levels have been observed in women, and low estrogen levels may be directly linked to the decrease in protein synthesis and increased prevalence of sarcopenia observed in postmenopausal women.^121-124

Estrogen supplementation is considered a potential strategy to protect against these losses in LM and strength, although earlier reports of increased health risks with ERT in postmenopausal women led to a decline in ERT use.^90,125 However, recent reevaluation regarding the effects of ERT indicates a general lack of risks and a number of significant health benefits from ERT use when initiated early and before the onset of menopause.^126,127 Indeed, ERT has been shown to reverse both menopause-related obesity and LM loss.¹²⁸ Furthermore, the increase in LM may be explained by increased muscle anabolism, and ERT may prevent sarcopenia in elderly women.¹²⁸ In contrast, some studies suggest that decreases in LM and strength associated with the natural decline in estrogen after menopause is as common in women who are long-term ERT users and women who are not using ERT suggesting no beneficial effect.¹²⁹ Nevertheless, there is a growing body of evidence supporting the beneficial effects of ERT for the maintenance and improvement in LM and strength.^{118,128,130,131} As well, the potential efficacy of ERT on skeletal muscle function and quality in combination with the additive health-related benefits associated with reduced risk of cardiovascular events, overall mortality, metabolic dysfunction, and bone should suggest strong consideration for ERT as possible treatment for sarcopenia in women.

Physical Activity

Even among active older adults there is evidence that aerobic activity may not mitigate the loss of muscle strength with aging. For example, Marcell et al¹³² recently observed in a longitudinal investigation of nearly 5 years that older men and women who exercised regularly (eg, jogging) showed no change in LM. However, participants lost isometric knee extensor and flexor strength at a rate of ~5% and 3.6% per year, respectively. Those data indicate an uncoupling of muscle strength and LM, indicating that even in active, middle-aged men and women there is a rapid annual loss of muscle strength. Recently, researchers from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study reported¹³³ that older adults who engaged in 12 months of physical activity exhibited decreased symptoms of frailty and preserved LM. Additionally, longitudinal data (2.6 years) from the LIFE Study show that older adults who participated in the physical activity intervention had an 18% lower incidence of major mobility disability and a 28% lower risk of persistent mobility disability compared with healthy education participants.¹³⁴

A recent systematic review¹³ of exercise interventions that employed general physical activity or combined modality training in sarcopenic older adults found that there are no studies that specifically recruited participants based on current criteria for diagnosing sarcopenia. Moreover, the results from studies that conducted exercise programs in older adults are mixed with regard to improvements in LM, strength, and physical functioning.¹³ For example, a study by Rydwik et al¹³⁵ found that a 12-week combined aerobic, balance, and RT intervention in older adult ≥75 years resulted in muscle strength improvement (~17%), while a nutrition counseling intervention did not. However, no improvement in gait speed was found in any group, and while RT was part of the training program, combined exercise programs cannot isolate the individual contribution of RT.

Resistance Training

Resistance training (RT) has long been known to improve skeletal muscle strength and function in older adults, and during the last 2 decades a surge in research studies exploring the potential effects of RT on sarcopenia-related outcomes has emerged. These studies, performed in clinical, laboratory,^136-138 and community-based settings¹³⁹ have employed a wide variety of intervention protocols, RT modalities (eg, free weights,¹⁴⁰ machines,¹⁴¹ body weight,¹⁴² whole-body vibration,¹⁴³ and elastic bands/tubing^144,145). Importantly, RT is a commonly used modality⁵ due to its safety, efficacy, and of a host of additional established benefits.

A recent meta-analysis by Peterson et al¹² examining the effects of RT on muscle strength reported that among 47 studies including 1079 men and women >50 years old that muscle strength increases with RT for upper and lower body exercises by 24% to 33%. A follow-up meta-analysis of RT on LM changes¹⁰ also found that LM was responsive to RT in middle-aged to older adults but not to the same extent as muscle strength. The results indicate that in 49 studies with a mean duration of ~20 weeks, adjusted LM increased by 1.1 kg, with evidence of a positive dose–response relationship as greater volume of RT elicited greater improvement. Although there was a wide range in the RT protocols used, most studies employed RT exercise programs that met or exceeded the American College of Sports Medicine’s (ACSM) recommendations for RT in older adults.¹⁰ These findings are supported by Stewart et al¹¹ who found that in most RT studies in adults who were >75 years that LM improves (3 of 4 studies) by 1.5% to 15.6%, with one study showing a decrease of 3%. Muscle strength improved in the 3 studies with increases of ~39% to 156%, while the study that did not show improvement in the intervention group showed far less of a decline during the course of the study versus the control group.

Importantly, RT in older adults is effective in improving muscle power, a strong predictor of physical function.^146-151 Recently, higher velocity RT protocols utilizing faster movement contractions have been investigated and studies suggest that muscle power improvements may be comparable to gains in maximum strength/force production after traditional lower velocity RT programs.⁵ There is also increasing evidence that improvements in muscle function in older adults can be accomplished using a host of training protocols at faster or slower movement velocities,¹⁵² which indicates that multiple approaches are possible for developing an exercise prescription to improve muscular fitness in older adults. Convincingly, these findings suggest that positive responses to RT for most muscle and physical function outcomes occur despite substantial variations in RT programs, populations studied, and outcomes measured. Furthermore, group means tend to show positive responses, although considerable individual responses to RT exist among older individuals due at least in part to sex^141,153,154 and genetic differences.^155,156 Although total genetic variation can explain a significant amount of muscle function variability,^157,158 this is a complex trait and individual gene polymorphisms likely do not have a substantial impact.

Current Recommendations for Older Adults to Improve Sarcopenia-Related Health Outcomes

Physical activity is perhaps the best-known treatment for many chronic diseases,¹⁵⁹ but older adults tend to be less active than younger adults.⁵ According to the Centers for Disease Control,¹⁶⁰ recent estimates suggest only 24% of adults ≥45 years and 16% aged 65 to 74 years meet recommendations for regular RT exercise. The ACSM recommends that older adults should participate in muscle strengthening activities for the major muscle groups 2 to 3 times per week on nonconsecutive days utilizing moderate- to vigorous-intensity RT (ie, ~65% to 80% of maximal strength¹⁵²) and this prescription should also include balance training exercises for general health and for improvement and maintenance of functional independence.^5,161

It should be emphasized that single-set training and/or fixed volume RT programs may not be advisable as a properly periodized (ie, planned variations such as regular alterations in training loads and movement velocities) RT training program for older adults is recommended to improve sarcopenia-related conditions.¹⁰ Although the optimal periodized RT program has not been determined, there is current research exploring this topic. In an early study, Newton et al examined the effects of a 10-week periodized RT intervention that incorporated faster movement velocities in older (n =10, age = 61 years) and younger (n = 8, age = 30 years) men.¹⁶² While younger men performed better in leg power and strength, older men exhibited a similar ability to improve muscle function. Villanueva et al¹⁶³ recently observed improvements in LM, stair climbing ability, and upper and lower muscle strength in older men in their late 60s after 8 weeks of periodized RT with short and long rest intervals, although there were significantly greater improvements in the shorter rest interval group. While more research, especially including women, needs to be conducted examining various periodized RT protocols, initial results indicate that older adults may respond similarly to their younger counterparts and that periodized RT programs should be strongly considered in future intervention studies targeted at reducing sarcopenia-related conditions in older adults.

Conclusions

Sarcopenia is a complex syndrome that is attributed to aging, genetic factors, hormonal shifts, diet factors, body composition, neuromuscular and skeletal muscle changes, physical activity, and other chronic disease states. While the individual contributions and interactions between these variables are still being investigated, it is now understood that the condition, as it is currently being defined, is associated with risk of disability in older adults.

It is unclear whether dynapenia or sarcopenia will be the future focus of clinical screening for at-risk patients, but it is encouraging that the current definitions of sarcopenia include measures of muscle strength and function in their algorithms. Research suggests that dynapenia and obesity may exert a stronger influence on clinical measures of function compared to low LM levels, and women may be particularly susceptible. If an older patient is not able to walk at a sufficient gait speed or rise from a chair and these symptoms are not secondary to a clearly diagnosed etiologic factor, this may be the most pressing reason to recommend an intervention strategy to reverse the age-related strength and function deficiencies based on the patient’s individual needs. Thus, health practitioners should encourage positive behavior change by promoting physical activity (especially RT) in older adults who have demonstrated deficits in gait speed or muscle strength according to the aforementioned consensus guidelines. Primary care physicians should include an evaluation of gait speed and muscle strength during routine examinations to identify those who currently are or may be at risk for sarcopenia. Moreover, preceding investigations strongly suggest that even active older adults remain at risk for age-related declines in muscle strength and functional limitations, and it is critical that older adults engage in a regular exercise program with special emphasis on improving muscle strength and physical function.

Footnotes

Authors’ Note

Both authors contributed equally to the writing of this article.

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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The Current Understanding of Sarcopenia

Abstract

Keywords

What Is Sarcopenia, and Why Is It Important to Clinicians?

Challenges to Diagnosing Sarcopenia

Functional Outcomes

Muscle Function

Lean Mass

Measuring Lean Mass

Moving Toward a Sarcopenia Definition Consensus

EWGSOP Guidelines

IWG Guidelines

How Do These New Definitions Compare?

What Can Be Done to Improve Lean Mass and Function in Sarcopenic Adults?

Protein Intake

A Brief Update on Hormone Replacement Therapy

Testosterone Replacement Therapy

Estrogen Replacement Therapy

Physical Activity

Resistance Training

Current Recommendations for Older Adults to Improve Sarcopenia-Related Health Outcomes

Conclusions

Footnotes

Authors’ Note

Declaration of Conflicting Interests

References