Skeletal muscle is an important link to an individual’s health and quality of life. The primary clinical interest in skeletal muscle is muscle strength. Muscle strength is a complex trait, influenced by biological, morphological, psychological, and environmental factors. Muscle strength is highly variable among individuals and has a strong genetic component. Though several genetic variants have been associated with muscle strength, genes comprising this genetic component are generally unknown. Research examining associations between genetic variants and muscle strength suffers from scientific challenges such as lack of replication, population stratification, and complexity of defining muscle phenotypes. Additionally, non-scientific challenges such as privacy and protection of genetic information and the questionable value of direct-to-consumer genetic marketing exist. How these challenges will influence research examining genetics and muscle strength is uncertain. Findings from this research may lead to improved treatment for muscle-related disease as well as improved health and quality of life. This may be realized through the development of genetic profiles that clinicians can implement into personalized treatment plans. This review will summarize the current literature regarding genetic variation and muscle strength. The authors’ focus will be on the muscle strength response to resistance training. Additionally, the authors discuss challenges and implications of this research.
Standards of medical care in diabetes- 2007. Diabetes Care. 2007;30(suppl 1): S4-S41.
2.
Roth SM, Ferrell RE, Hurley BFStrength training for the prevention and treatment of sarcopenia. J Nutr Health Aging. 2000;4:143-155.
3.
Karasik D., Kiel DPGenetics of the musculoskeletal system: a pleiotropic approach. J Bone Miner Res2008;23(6):788-802.
4.
Bassey EJ, Fiatarone MA, O’Neill EF, Kelly M., Evans WJ, Lipsitz LALeg extensor power and functional performance in very old men and women. Clin Sci. 1992;82:321-327.
5.
Paterson DH, Jones GR, Rice CLAgeing and physical activity: evidence to develop exercise recommendations for older adults. Can J Public Health. 2007 ;98(suppl 2): S69-S108.
6.
Metter EJ, Talbot LA, Schrager M., Conwit R.Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;57:B359-B365.
7.
Rantanen T., Harris T., Leveille SG, et al. Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci. 2000;55:M168-M173.
8.
Beunen G., Thomis M.Muscular strength development in children and adolescents. Pediatr Exerc Sci. 2000;12:174-197.
9.
Hubal MJ, Gordish-Dressman H., Thompson PD, et al. Variability in muscle size and strength gain after unilateral resistance training. Med Sci Sports Exerc. 2005;37:964-972.
10.
Arden NK, Spector TDGenetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res. 1997 ;12:2076-2081.
11.
Bouchard C. , Dionne FT, Simoneau JA, Boulay MRGenetics of aerobic and anaerobic performances . Exerc Sport Sci Rev. 1992;20:27-58.
12.
Thomis MAI , Beunen GP, Van Leemputte M., et al. Inheritance of static and dynamic arm strength and some of its determinants. Acta Physiol Scand . 1998;163:59-71.
13.
Reed T., Fabsitz RR, Selby JV, Carmelli D.Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Ann Hum Biol. 1991;18:425-432.
14.
Harmon E.The biomechanics of resistance exercise. In: Baechle TR, Earle RW, eds. Essentials of Strength Training and Conditioning. 2nd ed. Champaign, IL: Human Kinetics ; 2000:35.
15.
Kraemer WJPhysiological adaptations to anaerobic and aerobic endurance training programs . In: Baechle TR, Earle RW, eds. Essentials of Strength and Conditioning. 2nd ed. Champaign, IL: Human Kinetics; 2000:137-168.
16.
Sallis JF, Hovell MF, Hofstetter CRPredictors of adoption and maintenance of vigorous physical activity in men and women. Prev Med. 1992;21:237-251.
17.
Beunen G., Thomis M.Genetic determinants of sports participation and daily physical activity . Int J Obes Relat Metab Disord. 1999;23(suppl 3):S55-S63.
18.
Tiainen K., Pajala S., Sipila S., et al. Genetic effects in common on maximal walking speed and muscle performance in older women. Scand J Med Sci Sports. 2007;17:274-280.
19.
Maes HH, Beunen GP, Vlietinck RF, et al. Inheritance of physical fitness in 10-yrold twins and their parents. Med Sci Sports Exerc. 1996;28:1479-1491.
20.
Huygens W., Thomis MA, Peeters MW, Vlietinck RF, Beunen GPDeterminants and upper-limit heritabilities of skeletal muscle mass and strength . Can J Appl Physiol. 2004;29:186-200.
21.
Thibault MC , Simoneau JA, Cote C.Inheritance of human muscle enzyme adaptation to isokinetic strength training . Hum Hered. 1986;36:341-347.
22.
International Human GenomeSequencing Consortium.Finishing the euchromatic sequence of the human genome. Nature. 2004;431:931-945.
23.
Genetic Home Reference. In: US National Library of Medicine .
24.
International HapMap Consortium.A haplotype map of the human genome . Nature. 2005;437:1299-1320.
25.
Sachidanandam R., Weissman D., Schmidt SC, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms . Nature. 2001;409:928-933.
26.
Johnston TD , Edwards L.Genes, interactions, and the development of behavior. Psychol Rev. 2002;109:26-34.
27.
Yang N., MacArthur DG, Gulbin JP, et al. ACTN3 genotype is associated with human elite athletic performance . Am J Hum Genet. 2003;73:627-631.
28.
Lucia A., Gómez-Gallego F., Santiago C., et al. ACTN3 genotype in professional endurance cyclists. Int J Sports Med. 2006;27:880-884.
29.
Niemi AK, Majamaa K.Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet. 2005;13:965-969.
30.
Papadimitriou ID, Papadopoulos C., Kouvatsi A., Triantaphyllidis C.The ACTN3 gene in elite Greek track and field athletes. Int J Sports Med. 2008;29:352-355.
31.
Paparini A. , Ripani M., Giordano GD, Santoni D., Pigozzi F., Romano-Spica V.ACTN3 genotyping by real-time PCR in the Italian population and athletes. Med Sci Sports Exerc. 2007;39:810-815.
32.
Roth SM, Walsh S., Liu D., Metter EJ, Ferrucci L., Hurley BFThe ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. Eur J Hum Genet. 2008;16:391-394.
33.
Yang N., Macarthur DG, Wolde B., et al. The ACTN3 R577X polymorphism in East and West African athletes . Med Sci Sports Exerc. 2007;39:1985-1988.
34.
Clarkson PM , Devaney JM, Gordish-Dressman H., et al. ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol. 2005; 99:154-163. 35. Delmonico MJ, Kostek MC, Doldo NA, et al. Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. J Gerontol A Biol Sci Med Sci. 2007;62:206-212.
35.
Norman B., Esbjornsson M., Rundqvist H., Osterlund T., von Walden F., Tesch PAStrength, power, fiber types and mRNA expression in trained men and women with different ACTN3 R577X genotypes. J Appl Physiol . 2009;106:959-965.
36.
Vincent B., De Bock K., Ramaekers M., et al. ACTN3 (R577X) genotype is associated with fiber type distribution . Physiol Genomics. 2007;32:58-63.
37.
Rankinen T. , Bray MS, Hagberg JM, et al. The human gene map for performance and health-related fitness phenotypes: the 2005 update . Med Sci Sports Exerc. 2006;38:1863-1888.
38.
Zhang B., Tanaka H., Shono N., et al. The I allele of the angiotensin-converting enzyme is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet. 2003;63:139-144.
39.
Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F.An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343-1346.
40.
Gordon SE, Davis BS, Carlson CJ, Booth FWANG II is required for optimal overload-induced skeletal muscle hypertrophy . Am J Physiol Endocrinol Metab. 2001; 280:150-159.
41.
Westerkamp CM, Gordon SEAngiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1223-R1231.
42.
Myerson S., Hemingway H., Budget R., Martin J., Humphries S., Montgomery H.Human angiotensin I-converting enzyme gene and endurance performance . J Appl Physiol. 1999;87:1313-1316.
43.
Woods D., Hickman M., Jamshidi Y., et al. Elite swimmers and the D allele of the ACE I/D polymorphism . Hum Genet. 2001;108:230-232.
44.
Collins M., Xenophontos SL, Cariolou MA, et al. The ACE gene and endurance performance during the South African Ironman Triathlons. Med Sci Sports Exerc. 2004;36:1314-1320.
45.
Montgomery HE, Marshall R., Hemingway H., et al. Human gene for physical performance . Nature. 1998;393:221-222.
46.
Montgomery H. , Clarkson P., Barnard M., et al. Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. Lancet. 1999;353:541-545.
47.
Folland J., Leach B., Little T., et al. Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol . 2000;85:575-579.
48.
Pescatello LS , Kostek MA, Gordish-Dressman H., et al. ACE ID genotype and the muscle strength and size response to unilateral resistance training . Med Sci Sports Exerc. 2006;38:1074-1081.
49.
Hellebrandt FA , Parrish AM, Houtz SJCross education: the influence of unilateral exercise on the contralateral limb. Arch Phys Med. 1947;28:76-85.
50.
Williams AG , Day SH, Folland JP, Gohlke P., Dhamrait S., Montgomery HECirculating angiotensin converting enzyme activity is correlated with muscle strength . Med Sci Sports Exerc. 2005;37:944-948.
51.
Thomis MAI , Huygens W., Heuninckx S., et al. Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. Eur J Appl Physiol. 2004;92:267-274.
52.
McCauley T. , Mastana SS, Hossack J., MacDonald M., Folland JPHuman angiotensin-converting enzyme I/D and α-actinin 3 R577X genotypes and muscle functional and contractile properties . Exp Physiol. 2009;94:81-89.
53.
Charbonneau DE, Hanson ED, Ludlow AT, Delmonico MJ, Hurley BF, Roth SMACE genotype and the muscle hypertrophic and strength responses to strength training. Med Sci Sports Exerc . 2008;40:677-683.
54.
Forger NG, Roberts SL, Wong V., Breedlove SMCiliary neurotrophic factor maintains motoneurons and their target muscles in developing rats. J Neurosci. 1993 ;13:4720-4726.
55.
Ip NY, McClain J., Barrezueta NX, et al. The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron. 1993;10:89-102.
56.
Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H.Disruption of the CNTF gene results in motor neuron degeneration. Nature. 1993;365:27-32.
57.
Takahashi R. , Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T.A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet. 1994;7:79-84.
58.
Roth SM, Schrager MA, Ferrell RE, et al. CNTF genotype is associated with muscular strength and quality in humans across the adult age span. J Appl Physiol. 2001;90:1205-1210.
59.
De Mars G. , Windelinckx A., Beunen G., Delecluse C., Lefevre J., Thomis MAIPolymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. J Appl Physiol. 2007;102:1824-1831.
60.
Walsh S., Kelsey BK, Angelopoulos TJ, et al. CNTF 1357 G > A polymorphism and the muscle strength response to resistance training. J Appl Physiol. 2009;107:1235-1240.
61.
Arking DE, Fallin DM, Fried LP, et al. Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women. J Am Geriatr Soc. 2006;54:823-826.
62.
Kami K., Morikawa Y., Sekimoto M., Senba E.Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles. J Histochem Cytochem. 2000 ;48:1203-1213.
63.
Weis J., Lie DC, Ragoss U., et al. Increased expression of CNTF receptor α in denervated human skeletal muscle. J Neuropathol Exp Neurol. 1998;57:850-857.
64.
Roth SM, Metter EJ, Lee MR, Hurley BF, Ferrell REC174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women. J Appl Physiol. 2003 ;95:1425-1430.
65.
Kostek MA, Angelopoulos TJ, Clarkson PM, et al. Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. Med Sci Sports Exerc. 2009;41:1063-1071.
66.
Walsh S., Metter EJ, Ferrucci L., Roth SMActivin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 2007;102:2142-2148.
67.
Grabstein KH , Eisenman J., Shanebeck K., et al. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science. 1994;264: 965-968.
68.
Carbo N., López-Soriano J., Costelli P., et al. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim Biophys Acta. 2001;1526:17-24.
69.
Quinn LS, Anderson BG, Drivdahl RH, Alvarez B., Argiles JMOverexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. Exp Cell Res. 2002;280:55-63.
70.
Budagian V. , Bulanova E., Paus R., Bulfone-Paus S.IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev . 2006;17:259-280.
71.
Pistilli EE , Devaney JM, Gordish-Dressman H., et al. Interleukin-15 and interleukin-15Rα SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine. 2008;43:45-53.
72.
Riechman SE , Balasekaran G., Roth SM, Ferrell REAssociation of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol. 2004;97:2214-2219.
73.
Febbraio MA , Pedersen BKContraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev. 2005;33:114-119.
74.
Hiscock N., Chan MHS, Bisucci T., Darby IA, Febbraio MASkeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J. 2004;18:992-994.
75.
Fujita J., Tsujinaka T., Ebisui C., et al. Role of interleukin-6 in skeletal muscle protein breakdown and cathepsin activity in vivo. Eur Surg Res. 1996;28:361-366.
76.
Goodman MNInterleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med. 1994;205:182-185.
77.
Tsujinaka T. , Fujita J., Ebisui C., et al. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J Clin Invest. 1996;97:244-249.
78.
Jordanides N., Eskdale J., Stuart R., Gallagher G.Allele associations reveal four prominent haplotypes at the human interleukin-6 (IL-6) locus. Genes Immun. 2000;1:451-455.
79.
Ota N., Nakajima T., Nakazawa I., et al. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet. 2001;46:267-272.
80.
Osiri M., McNicholl J., Moreland LW, Louis Bridges S. Jr.A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans . Genes Immun. 1999;1:166-167.
81.
Fishman D., Faulds G., Jeffey R., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102: 1369-1376.
82.
Olivieri F. , Bonafe M., Cavallone L., et al. The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. Exp Gerontol. 2002;37:309-314.
83.
Walston J., Arking DE, Fallin D., et al. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol. 2005;40:344-352.
84.
Roth SM, Schrager MA, Lee MR, Metter EJ, Hurley BF, Ferrell REInterleukin-6 (IL6) genotype is associated with fat-free mass in men but not women. J Gerontol A Biol Sci Med Sci. 2003 ;58:B1085-B1088.
85.
Baker J., Liu JP, Robertson EJ, Efstratiadis A.Role of insulin-like growth factors in embryonic and postnatal growth . Cell. 1993;75:73-82.
86.
Musarò A., McCullagh K., Paul A., et al. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet. 2001;27:195-200.
87.
Kraemer WJ, Marchitelli L., Gordon SE, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol. 1990;69:1442-1450.
88.
Kostek MC, Delmonico MJ, Reichel JB, et al. Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. J Appl Physiol. 2005;98:2147-2154.
89.
Rosen CJ, Kurland ES, Vereault D., et al. Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density. J Clin Endocrinol Metab. 1998;83:2286-2290.
90.
Frayling TM , Hattersley AT, McCarthy A., et al. A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations . Diabetes. 2002;51:2313-2316.
91.
Hong Y., Pedersen NL, Brismar K., Hall K., De Faire U.Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1, and insulin levels in middle-aged and elderly twins . J Clin Endocrinol Metab. 1996;81:1791-1797.
92.
Rietveld I. , Janssen Jamjl, Hofman A., Pols HAP, van Duijn CM, Lamberts SWJA polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. Eur J Endocrinol. 2003;148:171-175.
93.
O’Dell SD, Miller GJ, Cooper JA, et al. Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males . Int J Obes. 1997;21:822-825.
94.
Gaunt TR, Cooper JA, Miller GJ, Day INM, O’Dell SDPositive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum Mol Genet . 2001;10:1491-1501.
95.
Gu D., O’Dell S., Chen X-H., Miller G., Day I.Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Hum Genet. 2002;110:173-181.
96.
Ukkola O., Sun G., Bouchard C.Insulin-like growth factor 2 (IGF2) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. Diabetologia. 2001;44:2231-2236.
97.
Schrager MA , Roth SM, Ferrell RE, et al. Insulin-like growth factor-2 genotype, fat-free mass, and muscle performance across the adult life span. J Appl Physiol. 2004;97:2176-2183.
98.
Sayer AA, Syddall H., O’Dell SD, et al. Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. Age Ageing. 2002;31:468-470.
99.
Grobet L., Royo Martin LJ, Poncelet D., et al. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat Genet. 1997;17:71-74.
100.
McPherron AC, Lee S.-J. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA . 1997;94:12457-12461.
101.
Schuelke M. , Wagner KR, Stolz LE, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med. 2004;350:2682-2688.
102.
McPherron AC, Lawler AM, Lee S.-J. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. Nature . 1997;387:83-90.
103.
Ferrell RE , Conte V., Lawrence EC, Roth SM, Hagberg JM, Hurley BFFrequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics. 1999;62:203-207.
104.
Saunders MA , Good JM, Lawrence EC, Ferrell RE, Li WH, Nachman MWHuman adaptive evolution at myostatin (GDF8), a regulator of muscle growth. Am J Hum Genet. 2006;79:1089-1097.
105.
Seibert MJ , Xue Q.-L, Fried LP, Walston JDPolymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women’s Health and Aging Study II cohort. J Am Geriatr Soc. 2001;49:1093-1096.
106.
Corsi AM, Ferrucci L., Gozzini A., Tanini A., Brandi MLMyostatin polymorphisms and age-related sarcopenia in the Italian population . J Am Geriatr Soc. 2002;50:1463.
107.
Ivey FM, Roth SM, Ferrell RE, et al. Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. J Gerontol A Biol Sci Med Sci. 2000;55:M641-M648.
108.
Fan HQ , Gu N., Liu F., et al. Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles. Acta Pharmacol Sin . 2007;28:410-416.
109.
Moon B., Kwan JJM, Duddy N., Sweeney G., Begum N.Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab. 2003;285:E106-E116.
110.
Palanivel R., Maida A., Liu Y., Sweeney G.Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin. Diabetologia. 2006;49:183-190.
111.
Pistilli EE , Gordish-Dressman H., Seip RL, et al. Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Obesity. 2007;15:392-402.
112.
Palanivel R., Sweeney G.Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett. 2005;579:5049-5054.
113.
Janssen Hcjp , Samson MM, Verhaar HJJ.Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr . 2002 ;75:611-615.
114.
Pfeifer M. , Begerow B., Minne HWVitamin D and muscle function. Osteoporos Int. 2002;13:187-194.
115.
Capiati D. , Benassati S., Boland RL1,25(OH)2-vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells. J Cell Biochem. 2002;86:128-135.
116.
Bischoff HA , Borchers M., Gudat F., et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001;33:19-24.
117.
Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell REVitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. J Gerontol A Biol Sci Med Sci. 2004;59:10-15.
118.
Windelinckx A., De Mars G., Beunen G., et al. Polymorphisms in the vitamin D receptor gene are associated with muscle strength in men and women. Osteoporos Int. 2007;18:1235-1242.
119.
Geusens P. , Vandevyver C., Vanhoof J., Cassiman JJ, Boonen S., Raus J.Quadriceps and grip strength are related to vitamin D receptor genotype in elderly non-obese women. J Bone Miner Res. 1997;12:2082-2088.
120.
Onder G., Capoluongo E., Danese P., et al. Vitamin D receptor polymorphisms and falls among older adults living in the community: results from the ilSIRENTE study. J Bone Miner Res. 2008;23:1031-1036.
121.
Arai H., Miyamoto KI, Taketani Y., et al. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res. 1997;12:915-921.
122.
Uitterlinden AG, Fang Y., Van Meurs JBJ, Pols HAP, Van Leeuwen Jptm.Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338:143-156.
123.
Grundberg E. , Brändström H., Ribom EL, Ljunggren O., Mallmin H., Kindmark A.Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. Eur J Endocrinol. 2004;150:323-328.
124.
Gennari L., Becherini L., Falchetti A., Masi L., Massart F., Brandi MLGenetics of osteoporosis: role of steroid hormone receptor gene polymorphisms . J Steriod Biochem Mol Biol. 2002;81:1-24.
125.
Jones JI, Clemmons DRInsulin-like growth factors and their binding proteins: biological actions . Endocr Rev. 1995;16:3-34.
126.
Peng L., Malloy PJ, Feldman D.Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter. Mol Endocrinol. 2004;18:1109-1119.
127.
Sweeney C., Murtaugh MA, Baumgartner KB, et al. Insulin-like growth factor pathway polymorphisms associated with body size in Hispanic and non-Hispanic white women. Cancer Epidemiol Biomarkers Prev. 2005;14:1802-1809.
128.
Little J., Higgins JPT, Ioannidis JPA, et al. Strengthening the reporting of genetic association studies (STREGA)-an extension of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. J Clin Epidemiol. 2009 ;62:597-608.
129.
De Moor MHM , Stubbe JH, Boomsma DI, De Geus EJC.Exercise participation and self-rated health: do common genes explain the association ? Eur J Epidemiol. 2007;22:27-32.
130.
Bray MS, Hagberg JM, Perusse L., et al. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc. 2009;41:35-73.
131.
Attia J., Ioannidis JP, Thakkinstian A., et al. How to use an article about genetic association: C: what are the results and will they help me in caring for my patients?JAMA. 2009;301:304-308.
132.
Roth SMPerspective on the future use of genomics in exercise prescription . J Appl Physiol. 2008;104:1243-1245.
133.
Roth SMLast word on viewpoint: perspective on the future use of genomics in exercise prescription. J Appl Physiol. 2008;104:1254.
134.
Burke W., Psaty BMPersonalized medicine in the era of genomics. JAMA . 2007;298:1682-1684.
135.
McGuire AL , Cho MK, McGuire SE, Caulfield T.The future of personal genomics. Science. 2007;317:1687.
136.
Atlas Sports Genetics. http://www.atlas-gene.com/ . Accessed March 5, 2009.
137.
23andme. https://www.23andme.com/ . Accessed March 5, 2009.
138.
deCODEme. http://www.decodeme.com/ . Accessed March 5, 2009.
139.
Navigenics. http://www.navigenics.com/ . Accessed March 5, 2009.
