This literature review examined the relationship of erectile function to patient satisfaction. Published correlation coefficients (r values) were sought between patient-reported outcomes (PROs; i.e., instruments/questionnaires) assessing erection or erectile function and PROs assessing individual sexual satisfaction, satisfaction in the context of the couple or relationship, or satisfaction with erection. The U.S. National Library of Medicine’s PubMed database was searched for English-language, randomized, double-blind, placebo-controlled trials of treatment with a phosphodiesterase type 5 inhibitor in men with erectile dysfunction (ED) who were not selected for any concomitant disease. Trials that reported correlations between an ED-specific and psychometrically validated PRO for an erection/erectile function concept and for a selected satisfaction concept were included. All correlations were positive, with almost all r values >" xbd="285" xhg="262" ybd="1530" yhg="1502"/>.50. The positive relationship between results on erection/erectile function PROs and results on satisfaction PROs is probably reinforced bidirectionally such that improved erection/erectile function improves satisfaction, which further improves erection and/or erectile function.
Abdo, C. ( 2007). The Male Sexual Quotient: A brief, self-administered questionnaire to assess male sexual satisfaction. Journal of Sexual Medicine, 4, 382-389.
2.
Abraham, L., Symonds, T., & Morris, M.F. ( 2008). Psychometric validation of a sexual quality of life questionnaire for use in men with premature ejaculation or erectile dysfunction. Journal of Sexual Medicine, 5, 595-601.
3.
Althof, S.E., Corty, E.W., Levine, S.B., Levine, F., Burnett, A.L., McVary, K., ... Seftel, A.D. ( 1999). EDITS: Development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology, 53, 793-799.
4.
Althof, S.E., O’Leary, M., Cappelleri, J.C., Glina, S., King, R., Tseng, L.-J., & Bowler, J.L. ( 2006). Self-esteem, confidence, and relationships in men treated with sildenafil citrate for erectile dysfunction: Results of two double-blind, placebo-controlled trials. Journal of General Internal Medicine , 21, 1069-1074.
5.
Althof, S.E., O’Leary, M.P., Cappelleri, J.C., Hvidsten, K., Stecher, V.J., Glina, S., ... Siegel, R.L. ( 2006). Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. Journal of Sexual Medicine, 3, 521-529.
6.
Bocchio, M., Pelliccione, F., Mihalca, R., Ciociola, F., Necozione, S., Rossi, A., . . . Francavilla, S. (2009). Treatment of erectile dysfunction reduces psychological distress. International Journal of Andrology , 32, 74-80.
7.
Bodur, H., Borman, P., Ozdemir, Y., Atan, C., & Kural, G. ( 2006). Quality of life and life satisfaction in patients with Behcet’s disease: Relationship with disease activity. Clinical Rheumatology, 25, 329-333.
8.
Buvat, J., Hatzichristou, D., Maggi, M., Farmer, I., Martinez-Jabaloyas, J.M., Miller, P.J., & Schnetzler, G. (2008). Efficacy, tolerability, and satisfaction with sildenafil citrate 100-mg titration compared with continued 50-mg dose treatment in men with erectile dysfunction. BJU International, 102, 1645-1650.
9.
Cappelleri, J.C., Althof, S.E., O’Leary, M.P., Glina, S., King, R., Stecher, V.J., . . . Siegel, R.L. ( 2007). Clinically meaningful improvement on the Self-Esteem and Relationship questionnaire in men with erectile dysfunction. Quality of Life Research, 16, 1203-1210.
10.
Cappelleri, J.C., Althof, S.E., O’Leary, M.P., Tseng, L.J., U.S. SEAR Study Group, & International SEAR Study Group. (2008). Analysis of single items on the Self-Esteem and Relationship questionnaire in men treated with sildenafil citrate for erectile dysfunction: Results of two double blind, placebo-controlled trials. BJU International, 101, 861-866.
11.
Cappelleri, J.C., Althof, S.E., Siegel, R.L., Shpilsky, A., Bell, S.S., & Duttagupta, S. (2004). Development and validation of the Self-Esteem and Relationship (SEAR) questionnaire in erectile dysfunction . International Journal of Impotence Research, 16, 30-38.
12.
Cappelleri, J.C., Bushmakin, A.G., Symonds, T., & Schnetzler, G. (2009). Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4) . Journal of Sexual Medicine, 6, 809-819.
13.
Cappelleri, J.C., & Rosen, R.C. ( 2005). The Sexual Health Inventory for Men (SHIM): A 5-year review of research and clinical experience. International Journal of Impotence Research, 17, 307-319.
14.
Carson, C., Giuliano, F., Goldstein, I., Hatzichristou, D., Hellstrom, W., Lue, T., . . . Rosen, R. ( 2004). The "effectiveness" scale-therapeutic outcome of pharmacologic therapies for ED: An international consensus panel report. International Journal of Impotence Research, 16, 207-213.
15.
Casey, R., Tarride, J.E., Keresteci, M.A., & Torrance, G.W. (2006). The Erectile Function Visual Analog Scale (EF-VAS): A disease-specific utility instrument for the assessment of erectile function. The Canadian Journal of Urology, 13, 3016-3025; discussion 3026.
16.
Cieza, A., & Stucki, G. ( 2005). Content comparison of health-related quality of life (HRQOL) instruments based on the international classification of functioning, disability and health (ICF). Quality of Life Research, 14, 1225-1237.
17.
Cook, D.J., Mulrow, C.D., & Haynes, R.B. ( 1997). Systematic reviews: Synthesis of best evidence for clinical decisions. Annals of Internal Medicine, 126, 389-391.
18.
Corona, G., Jannini, E.A., & Maggi, M. ( 2006). Inventories for male and female sexual dysfunctions. International Journal of Impotence Research, 18, 236-250.
19.
Corona, G., Mannucci, E., Petrone, L., Ricca, V., Balercia, G., Giommi, R., . . . Maggi. M. ( 2006). Psycho-biological correlates of free-floating anxiety symptoms in male patients with sexual dysfunctions. Journal of Andrology, 27, 86-93.
20.
Corty, E.W., Althof, S.E., & Kurit, D.M. ( 1996). The reliability and validity of a sexual functioning questionnaire. Journal of Sex & Marital Therapy, 22, 27-34.
21.
Data on file. (2008). New York, NY: Pfizer.
22.
DiBenedetti, D.B., Gondek, K., Sagnier, P.P., Kubin, M., Marquis, P., Keininger, D., . . . Fugl-Meyer, A.R. (2005). The treatment satisfaction scale: A multidimensional instrument for the assessment of treatment satisfaction for erectile dysfunction patients and their partners. European Urology, 48, 503-511.
23.
Dunnum, L. ( 1990). Life satisfaction and spinal cord injury: The patient perspective. Journal of Neuroscience Nursing, 22, 43-47.
24.
Edwards, D., Hackett, G., Collins, O., & Curram, J. ( 2006). Vardenafil improves sexual function and treatment satisfaction in couples affected by erectile dysfunction (ED): A randomized, double-blind, placebo-controlled trial in PDE5 inhibitor-naive men with ED and their partners . Journal of Sexual Medicine, 3, 1028-1036.
25.
Fisher, W.A., Rosen, R.C., Eardley, I., Sand, M., & Goldstein, I. ( 2005). Sexual experience of female partners of men with erectile dysfunction: The female experience of men’s attitudes to life events and sexuality (FEMALES) study. Journal of Sexual Medicine , 2, 675-684.
26.
Fugl-Meyer, A.R., Althof, S., Buvat, J., Paget, M.A., Sotomayor, M., & Stothard, D. ( 2009). Aspects of sexual satisfaction in men with erectile dysfunction: A factor analytic and logistic regression approach. Journal of Sexual Medicine, 6, 232-242.
27.
Fugl-Meyer, A.R., Lodnert, G., Branholm, I.B., & Fugl-Meyer, K.S. (1997). On life satisfaction in male erectile dysfunction. International Journal of Impotence Research, 9, 141-148.
28.
Fugl-Meyer, K.S., Stothard, D., Belger, M., Toll, A., Berglund, O., Eliasson, T., & Fugl-Meyer, A.R. (2006). The effect of tadalafil on psychosocial outcomes in Swedish men with erectile distress: A multicentre, non-randomised, open-label clinical study. International Journal of Clinical Practice, 60, 1386-1393.
29.
Gil, A., Martinez, E., Oyaguez, I., Palacios, G., & Rejas, J. ( 2001). Erectile dysfunction in a primary care setting: Results of an observational, no-control-group, prospective study with sildenafil under routine conditions of use. International Journal of Impotence Research, 13, 338-347.
30.
Goldstein, I., Fisher, W.A., Sand, M., Rosen, R.C., Mollen, M., Brock, G., . . . Vardenafil Study Group. (2005 ). Women’s sexual function improves when partners are administered vardenafil for erectile dysfunction: A prospective, randomized, double-blind, placebo-controlled trial. Journal of Sexual Medicine, 2, 819-832.
31.
Hartman-Maeir, A., Soroker, N., Ring, H., Avni, N., & Katz, N. ( 2007). Activities, participation and satisfaction one-year post stroke. Disability and Rehabilitation, 29, 559-566.
32.
Hedon, F. ( 2003). Anxiety and erectile dysfunction: A global approach to ED enhances results and quality of life. International Journal of Impotence Research, 15, S16-S19.
33.
Heiman, J.R., Talley, D.R., Bailen, J.L., Oskin, T.A., Rosenberg, S.J., Pace, C.R., . . . Bavendam, T. ( 2007). Sexual function and satisfaction in heterosexual couples when men are administered sildenafil citrate (Viagra) for erectile dysfunction: A multicentre, randomised, double-blind, placebo-controlled trial. British Journal of Obstetrics and Gynaecology, 114, 437-447.
34.
Higgins, J.P.T., & Green, S. ( 2009). Cochrane handbook for systematic reviews of interventions . Oxford, England: Cochrane Collaboration .
35.
Jones, L.A., Klimberg, I.W., McMurray, J.G., Padula, R., Tseng. L.-J., & Stecher, V.J. ( 2008). Effect of sildenafil citrate on the male sexual experience assessed with the Sexual Experience Questionnaire: A multicenter, double-blind, placebo-controlled trial with open-label extension. Journal of Sexual Medicine, 5, 1955-1964.
36.
Kadioglu, A., Grohmann, W., Depko, A., Levinson, I.P., Sun, F., & Collins, S. ( 2008). Quality of erections in men treated with flexible-dose sildenafil for erectile dysfunction: Multicenter trial with a double-blind, randomized, placebo-controlled phase and an open-label phase. Journal of Sexual Medicine, 5, 726-734.
37.
Latini, D.M., Penson, D.F., Colwell, H.H., Lubeck, D.P., Mehta, S.S., Henning, J.M., . . . Lue, T.F. ( 2002). Psychological impact of erectile dysfunction: Validation of a new health related quality of life measure for patients with erectile dysfunction. Journal of Urology, 168, 2086-2091.
38.
Locker, D., Clarke, M., & Payne, B. ( 2000). Self-perceived oral health status, psychological well-being, and life satisfaction in an older adult population. Journal of Dental Research, 79, 970-975.
39.
Loran, O.B., Stroberg, P., Lee, S.W., Park, N.C., Kim, S.W., Tseng, L.J., . . . Stecher, V.J. (2009). Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: Effect on the sexual experience and reducing feelings of anxiety about the next intercourse attemptJournal of Sexual Medicine, 6, 2826-2835.
40.
MacDonagh, R., Ewings, P., & Porter, T. ( 2002). The effect of erectile dysfunction on quality of life: Psychometric testing of a new quality of life measure for patients with erectile dysfunction. Journal of Urology, 167, 212-217.
41.
Mallis, D., Moisidis, K., Kirana, P.S., Papaharitou, S., Simos, G., & Hatzichristou, D. (2006). Moderate and severe erectile dysfunction equally affects life satisfaction. Journal of Sexual Medicine, 3, 442-449.
42.
Meade, M.O., & Richardson, W.S. (1997). Selecting and appraising studies for a systematic review. Annals of Internal Medicine , 127, 531-537.
43.
Moncada, I., Micheltorena, C.F., Martinez-Sanchez, E.M., & Gutierrez, J.R. (2008). Evaluation of the psychometric properties of the life satisfaction checklist as a screening tool for erectile dysfunction. Journal of Sexual Medicine, 5, 83-91.
44.
Mulhall, J., King, R., Glina, S., & Hvidsten, K. ( 2008). Importance of and satisfaction with sex among men and women worldwide: Results of the Global Better Sex Survey. Journal of Sexual Medicine, 5, 788-795.
45.
Mulhall, J.P., Goldstein, I., Bushmakin, A.G., Cappelleri, J.C., & Hvidsten, K. ( 2007). Validation of the Erection Hardness Score (EHS). Journal of Sexual Medicine, 4, 1626-1634.
46.
Mulhall, J.P., King, R., Kirby, M., Hvidsten, K., Symonds, T., Bushmakin, A.G., . . . Cappelleri, J.C. (2008). Evaluating the sexual experience in men: Validation of the Sexual Experience Questionnaire. Journal of Sexual Medicine, 5, 365-376.
47.
O’Leary, M.P., Althof, S.E., Cappelleri, J.C., Crowley, A., Sherman, N., & Duttagupta, S. (2006). Self-esteem, confidence and relationship satisfaction of men with erectile dysfunction treated with sildenafil citrate: A multicenter, randomized, parallel group, double-blind, placebo controlled study in the United States. Journal of Urology, 175, 1058-1062.
48.
Porst, H., Gilbert, C., Collins, S., Huang, X., Symonds, T., Stecher, V., & Hvidsten, K. ( 2007). Development and validation of the Quality of Erection Questionnaire. Journal of Sexual Medicine, 4, 372-381.
49.
Rosen, R., Goldstein, I., Huang, X.Y., Bangerter, K., & Taylor, T. ( 2007). The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: Results of a randomized controlled trial with vardenafil. Journal of Sexual Medicine, 4, 1009-1021.
50.
Rosen, R.C., Cappelleri, J.C., & Gendrano, N., III. (2002). The International Index of Erectile Function (IIEF): A state-of-the-science review. International Journal of Impotence Research, 14, 226-244.
51.
Rosen, R.C., Cappelleri, J.C., Smith, M.D., Lipsky, J., & Peña, B.M. (1999). Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. International Journal of Impotence Research, 11, 319-326.
52.
Rosen, R.C., Riley, A., Wagner, G., Osterloh, I.H., Kirkpatrick, J., & Mishra, A. ( 1997). The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology, 49, 822-830.
53.
Rosen, R.C., Wincze, J., Mollen, M.D., Gondek, K., McLeod, L.D., & Fisher, W.A. ( 2007). Responsiveness and minimum important differences for the erection quality scale. Journal of Urology, 178, 2076-2081.
54.
Rubio-Aurioles, E., Porst, H., Eardley, I., & Goldstein, I. ( 2006). Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: A randomized, double-blind, pooled crossover study. Journal of Sexual Medicine, 3, 1037-1049.
55.
Saeki, S., Chisaka, H., & Hachisuka, K. ( 2005). Life satisfaction and functional disabilities in long-term survivors after first stroke. Journal of UOEH, 27, 171-177.
56.
Sandau, K.E., Lindquist, R.A., Treat-Jacobson, D., & Savik, K. ( 2008). Health-related quality of life and subjective neurocognitive function three months after coronary artery bypass graft surgery. Heart & Lung, 37, 161-172.
57.
Shen, W., Kotsanos, J.G., Huster, W.J., Mathias, S.D., Andrejasich, C.M., & Patrick, D.L. ( 1999). Development and validation of the Diabetes Quality of Life Clinical Trial Questionnaire. Medical Care, 37, AS45-66.
58.
Swindle, R., Cameron, A., & Rosen, R. ( 2006). A 15-item short form of the psychological and interpersonal relationship scales. International Journal of Impotence Research , 18, 82-88.
59.
Swindle, R.W., Cameron, A.E., Lockhart, D.C., & Rosen, R.C. ( 2004). The psychological and interpersonal relationship scales: Assessing psychological and relationship outcomes associated with erectile dysfunction and its treatment. Archives of Sexual Behavior , 33, 19-30.
60.
Torrance, G.W., Keresteci, M.A., Casey, R., Ryan, N.C., & Tarride, J.E. ( 2006). Measuring quality of life: The development and initial validation of the patient-reported erectile function assessment instrument . International Journal of Technology Assessment in Health Care, 22, 372-378.
61.
Torrance, G.W., Keresteci, M.A., Casey, R.W., Rosner, A.J., Ryan, N., & Breton, M.C. ( 2004). Development and initial validation of a new preference-based disease-specific health-related quality of life instrument for erectile function . Quality of Life Research, 13, 349-359.
62.
Wagner, T.H., Patrick, D.L., McKenna, S.P., & Froese, P.S. ( 1996). Cross-cultural development of a quality of life measure for men with erection difficulties. Quality of Life Research , 5, 443-449.
63.
Wincze, J., Rosen, R., Carson, C., Korenman, S., Niederberger, C., Sadovsky, R., . . . Merchant, S. ( 2004). Erection quality scale: Initial scale development and validation. Urology, 64, 351-356.
64.
Woodward, J., Hass, S., & Woodward, P. ( 2002). Reliability and validity of the sexual life quality questionnaire (SLQQ). Quality of Life Research, 11, 365-377.
65.
Zhang, K. ( 2005). From better erection to better sex: Viagra updates 2005 . Zhonghua Nan Ke Xue, 11, 796-799.
