The patency of arteriovenous anastomosis (AVA) in the renal microcircula tion has been a controversial topic.
To study the possibility of AVA as part of the renal microcirculation a cathe ter was placed under radiological control in a renal artery in each of eight anesthetized dogs.
Albumin microspheres 15-52 micra in diameter labeled with 3-5 mCi of Tc99m were injected into the renal artery through this catheter.
Counts over the lungs, kidneys and bladder were obtained with detectors. The spatial distribution of the radioactivity in the dogs were also studied by scintigraphy and there was imaging of the kidneys which corroborates the find ings obtained with detectors, there was no visualization of the lungs. In some studies the bladder was visualized because of the presence of free Tc99m.
The lack of radioactivity in the lungs indicates that there are not patent AVA in canine kidneys because the radioactive microspheres injected in the renal artery became lodged in the arterioles, for being larger than the capillaries they could not cross to the renal veins.
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References
1.
Ciara M.: Die arteriovenous anastomosen. Second Edition. Springer Verlag, Wien, 1956.
2.
Bencs'ath P. , Nagy Z., Tornyal K., Vaslaky L.: Functional study of the arteriovenous anastomosed of the kidney. II. Intrarenal circulation in experimental dehydration. Acta Physiol Acad Sci Hung36: 239, 1969.
Gomori P.: Arteriovenous shunts of the kidney. Acta Med Acad Sci Hung25: 267, 1969.
5.
Gomori P., Harsing L., Kallay K., et al: Arteriovenous anastomosed in the kidney. I. Renal blood flow following the infusion of serum albumin. Acta Physiol Acad Sci Hung35: 201, 1969.
6.
Almgard LE, Granberg PO, Ljungqvist A.: The functional significance of arteriovenous anastomoses. Nephron5: 161,1968.
7.
Harsing L., Pelley K.: Die bestimmung der nierendurchblutung auf grund der ablagerung und verteilung von RbPflugers Arch ges Physiol285: 302, 1965 .
8.
Smith Homer W: The kidney, Oxford University Press, New York, 1951.
9.
Trueta J., Barclay AE, Franklin KJ, et al: Studies of the renal circulation. Oxford , Blackwell, 1947.
10.
Coelho JB, Bradley SE: Function of the nephron population during haemorrhagic hypotension in the dog, with special reference to the effect of osmotic diuresis. J Clin Invest43: 386, 1964.
11.
Gomori P., Nagy Z., Zoinai B., et al: The problem of the arteriovenous anastomoses of the kidney. IV. Extraction of PAH and 0-2 and corrosion studies in the denervated kidney in traumatic shock and following human serum albumin administration. Acta Med Acad Sci Hung21: 197, 1965.
12.
Gomori P., Kallay K., Nagy X., Szabo Z.: The problem of the arteriovenous anastomoses of the kidney. II. Effect of human serum albumin and dehydralazine on the opening of renal shunts. Acta Med Acad Sci Hung18: 119, 1962.
13.
Gomori P.: The problem of arteriovenous anastomoses of the kidney. IV. Extraction of PAH and corrosion studies in the denervated kidney in traumatic shock and following serum albumin administration. Acta Med Acad Sci Hung21: 197, 1965.
14.
Gomori P., Munkacsi I., Nagy L., et al: Ischaemia and arteriovenous anastomoses of the kidney in shock, haemorrhage, dehydration and arterial hypoxia in dogs. Acta Med Acad Sci Hung18: 119, 1962.
15.
Gomori P., Nagy Z., Jakab I.: The problem of the arteriovenous anastomoses in the kidney. I. Renal extraction of PAH and O2 in dehydration, haemorrhagic hypotension and arterial hypoxia. Acta Med Sci Hung30: 153, 1964.
16.
Gomori P., Zolnai B., Nagy Z., et al: The problem of renal ischaemia and of the arteriovenous anastomoses of the kidney. III. New corrosion studies in dehydration, haemorrhagic, traumatic and ischaemic shock, arterial hypoxia and after serum albumin treatment. Acta Med Sci Hung29: 169, 1964.
17.
Rosenbusch G., Vincent J., Van Douveren W., et al: The intrarenal localization of renorenal collaterals in the dog. Fortsch Gel Roentgenstr Nuclear Med126: 407, 1977.
18.
Ljungqvist A.: The intrarenal arterial patterns in the normal and diseased human kidney. Acta Med Scand Suppl401: 1963.
19.
Sondag TJ, Patel SK, Petasnick JP, et al: Hypernephromas with massive arteriovenous fistulas. Amer J Roentgen117: 97, 1973.
20.
Siegelman SS, Goldman AG: The Trueta phenomenon-angiographic-documentation in man. Radiology90: 1048, 1968.
21.
Staple TW, Chiang Dtc: Arteriography following renal transplantation. Amer J of Roentgenology101: 669, 1967.
22.
Vinik M., Smellie Wab, Freed TA, et al: Angiographic evaluation of the human homotransplant kidney. Radiology92: 873, 1969.
23.
Wise GJ, Bosniak MA, Hudson PB: Arteriovenous fistula associated with renal cell carcinoma of kidney. Report of three cases with cardiovascular findings. Brit J Urol39: 170, 1967.
24.
Vinik M., Smellie Wab, Freed TA, et al: Renal ischaemic and homograft rejection-preliminary angiographic data in the dog. Invest Radiology4: 252, 1969.
25.
Wright FW, Fletcher EW, Oliver DO: Arteriovenous shunting occuring with rejection in a renal transplant. Br J Urol44: 395, 1972.
26.
Samuel E.: Radiology in the diagnosis of renal ejection. ClinicalRadiology21: 109, 1970.
Siegel NE, Giargiana FF Jr, Wagner HN Jr: Verification and quantification of anatomic arteriovenous shunting in a hypernephroma . J Urology112: 16, 1974.
30.
Porter KA: Morphological aspects of renal homograft rejection. Brit Med Bull21: 171, 1965.
31.
Ljungqvist A., Lagergren C.: The arterial vasculature of renal adenocarcinomas . Acta Pathol Microbiol Scand67: 55, 1966.
32.
Kountz SL, Laub DR, Cohn R.: Detecting and treating early renal homotransplant rejection. J Amer Med Ass191: 125, 1965.
33.
Porter KA: Pathological changes in transplanted kidneys. In: Experience in renal transplantation. Ed. by Starzl TE.Philadelphia, London, Saunders, 1964, pp. 299-359.
34.
Gomori P., Munkacsi I., Szalay E., et al: Intrarenal blood circulation in chronic renal failure. I. Human Material Acta Med Acad Sci Hung18: 441, 1962.
35.
Gomori P., Szalay E., Tu SH, Zolnai B.: Intrarenal blood circulation in chronic renal insufficiency. II. Experimental Masugi nephritis. Acta Med Acad Sci Hung18: 451, 1962.
36.
Hall V.: The protoplasmatic basis of glomerular as revealed by plastic reconstruction from several sections. Anat Rev125: 433, 1956 .
37.
Boyer CC: The vascular pattern of the renal glomerlus as revealed by plastic reconstruction from several sections. Anat Rev125: 433, 1956 .
38.
Lewis OJ: Vascular architecture of developing human renal glomerlus. Anat Rec135: 93, 1959.
39.
Staubesand J., Hammerson F.: Zur problematik des nachweises arteriovenoser anatomosen in injektionspraparat. Z Anat119: 365, 1956 .
40.
Kugelgen AV , Kuhlo B., Juhlo W., Otto J.: Die gefassarchietektur der niere. Thieme, Stuggart. 111: 1959.
41.
Constantini S., Arla AM, Vercellio G., et al: Dimostrazione sperimentale dell'esistenza di shunts arteriovenosi nel rene di coniglio anestetizatto. Minerva Cardioangiological18: 687, 1970.
42.
Wolfenson D. : Blood flow through arteriovenous anastomoses and its thermal function in the laying hen. J Physiol London334: 395, 1983.
43.
Lin KL, Lopez L., Hellums JD: Blood flow in capillaries. Microvascular Research5: 7, 1973.
44.
Phibbs RH, Wyler R., Neutze J.: Rheology of microspheres injected into circulation of rabbits. Nature216: 1339, 1967.
45.
Rhodes BA, Zolle I., Buchanan JW, Wagner HN Jr: Radioactive abumin microspheres for studies of the pulmonary circulation. Radiology94: 1453, 1969.
46.
Opjord ES, Clausen G.: Intarenal flow of microspheres and red blood cells: Skimming in slit and tube models. Am J Physiol429, 1983.
47.
Slotkoff M. , Logan A., Jose PA, et al: Microsphere measurement of intrarenal circulation of the dog. Circ Research28: 158, 1971.
48.
Harvey W.: In: Exercitatio anatomica de motu cordis et sanguinis in animalibus . Ed. by Leake CD.Illinois, CC Thomas, 1958, p. 81.
49.
Clark ER, Clark Ell: Oservations on living arteriovenous anastomoses as seen in transparent chambers introduced into the rabbit's ear. J Anat54: 229, 1934.
50.
Prinzmental M., Ornitz EM, Simkin B., Bergan HC: Arteriovenous anastomoses in liver, spleen and lungs. Am J Physio152: 48, 1948.
51.
Best and Taylor: In: Physiological basis of medical practice. Ed. by Best CH , Taylor NB. Sixth Edition. Baltimore, The Williams & Wilkin's Co, 1966, p. 453.
52.
The microcirculation, a symposium. Ed. by Winters and Best, CG Thomas, 111, 1969.
