Abstract
The gluing of tissue with highly concentrated fibrinogen, designated in the following briefly as fibrin gluing, is a relatively old technique. Bergel already reported in 1909 on first trials of hemostasis with fibrin powder.1 In 1915, Grey used a fibrin solution prepared from sheep blood for hemostasis in intracranial operations.2 In 1944, Cronkite fixed skin transplants with a fibrinogen-thrombin mixture. Difficulties occurred with the adhesivity, probably in consequence of low fibrinogen concentrations.3 Since the ex perimental and clinical investigations of Spängler et al.,4,3 a large number of possible applications of fibrin gluing has been described.6-12
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