The use of commercially produced fibrin glue, successfully used for many surgical procedures in European operating theatres, is prohibited in the USA due to FDA regulations. In this presentation the authors demonstrate the extraction of fibrinogen from the patient's own blood, thus avoiding possible viral contamination and allergenisity. Clinical and experimental applications are demonstrated.
Get full access to this article
View all access options for this article.
References
1.
Grey E.G.: Fibrin as a hemostatic in cerebral surgery. Surg Gyn Obs 21:425-54, 1915.
2.
Young JZ, Oxid MA and Medawar PB: Fibrin suture of peripheral nerves. Lancet: 126, 1940.
3.
Tarlov IM and Bernard B.: Plasma clot and silk suture of nerves. Surg Gyn Obs 76:366-374, 1943.
4.
Spangler HP: Gewebeklebung und lokale Blutstillung mit Fibrinogen, Thrombin and Blutgerinnungsfaktor XIII (experimentelle untersuchungen and klinische Erfahrungen). Wiener klinische Wochenschrift88. Jahrgang 1976 Supplementum 49
5.
Schimpf KL: Fibrinogen, Fibrin und Fibrinkleber/fibrinogen, fibrin and fibrin glue. FKSchattauer Verlag, Stuttgart, N.Y. 1980.
6.
Pearl RM, Wustrack KO, Harbury C., et al: Microvascular anastomosis using a blood product sealant-adhesive . Surg Gyn Obs 144:227, 1977.
Staindl O.: Die Gewebeklebung mit hochkonzentriertem, humanen Fibrinogen. Archives of oto-rhino laryngology, Springer-Verlag228:217-219, 1977.
9.
Matras H., Jesch W., Kletter G. and Dinges HP: Spinale Duraklebung mit "Fibrinkleber, eine experimentelle Studie. Wiener Klinische Wochenschrift Jg.90, Heft 12, 9 June, 1978.
10.
Rauchenwald K., Henning K. and Urlesberger : Humanfibrinklebung bei Nephrotomie. Helv Chir Acta45:283-286, 1978.
11.
Stemberger A., Fritsche HM, Primbs P. and Blumel G.: Fibrinogen-konzentrate und Kollagenschwamme zur Gewebeklebung. Forschung und PraxisMed Welt Bd 29/Heft 17, 1978.
12.
Burleson RL and Ennulat N.: Fibrin adherence to biologic tissues. J Surg Res25:523-529, 1978.
13.
Petterson S. , Hedelin H., Jansson I. and Teger-Nilsson A-C.: Fibrin occlusion of a vesicovaginal fistula. Lancet, April 28: 933, 1979.
14.
Adams G., Lerner R. and Gestring GF: Autologous fibrin glue for lymphovenous anastomosis. 8th Internat'1 Congress Lymphology, Sept 20-25, Montreal , Canada (Congress report).
15.
Staindl O.: Tissue adhesion with highly concentrated human fibrinogen in otolaryngology . Annals Otal88, 1979.
16.
Seelich T., Redl H.: Theoretische Grundlagen des Fibrinklebers, Fibrinogen, Fibrin and Fibrin Glue Book. F.D. Schattauer, Verlag-Stuttgart, NY.
17.
Revocation of FDA license with fibrinogen: FDA Drug Bulletin 9-80 II.
18.
Bove JR: Fibrinogen — is the benefit worth the risk?Transfusion18(2), 1978.
19.
Goodnight S. Jr: Cryoprecipitate and fibrinogen. JAMA241(6), 1979.
20.
Personal communication: Dr K Eibl, (Immuno) Vienna, Austria June 9, 1981.
21.
Reimer H., Rene H. and Henner G.: Acid precipitation of fibrinogen. A technique for isolation of fibrinogen and its derivatives from highly diluted solutions. Hoppe-Seyler's Z. Physiol Chem Bd359, S.759-763, June 1978.
22.
Gestring GF , Mendoza E., Lerner R. and Gottlob R.: Autologous fibrin as sealant for Microvascular Anastomosis. American College ofAngiology, 28th annual meeting, New Orleans, LA. Dec 9-13, 1981.
23.
Gestring GF , Lerner R. and Adams G.: Hemostasis with autologous fibrinogen. Acta Chir Aust Heft 2/Jahrgang 13, 1981.
24.
Gestring GF, Adams G., Lerner R. and Gottlob R.: Autologous Fibrin Glue for Microanastomosis. Springer-Verlag , 1982 (in press).
25.
Cordeiro AK and Baracat FF: Novas tecnicas de anastomose linfovenosa . Maternidade e Infancia, Abril-Junho 1975 .
26.
Richling B. : Homologous controlled-viscosity fibrin for endovascular embolization. Acta Neurochirurg150, 1982.
27.
Webster RG, Slansky H., et al: The use of adhesives for the closure of corneal perforations . Arch Ophthal80, 1968.
28.
Kletter G.: The Extra-intracranial Bypass Operation. Springer-Verlag , 1980.
29.
Koos WT, Schuster H., Kletter G., et al: Indications and results of extracranialintracranial bypass in patients with completed stroke. Modern Neurosurgery1. Springer-Verlag, Berlin-Heidelberg, 1982.
30.
Gottlob R., Piza H., Gottlob I. and Gestring GF: Replacement of small veins by autologous grafts: Application of an endothelium-preserving technique. Vasc Surg16(1), 1982, Vienna, Austria and New York, NY.
