The epithelioid hemangioendothelioma (EHE) is a rare type of endothelial neoplasm found mainly in soft tissues and visceral organs and in extraordinary cases in large veins like the iliac veins. Currently, there is an active discussion in which EHE behavior, classification, new diagnostic tools, and treatment procedures are proposed. Here, we present 2 cases of EHE and discuss our experience in diagnosis and treatment of this neoplasm.
EnzingerFMWeissSW. Hemangioendothelioma: vascular tumors of intermediate malignancy. In: EnzingerFM, ed. Soft Tissue Tumors. St Louis, MO: Mosby; 1995:627–640.
2.
GohSGCalonjeE. Cutaneous vascular tumors: an update. Histopathology. 2008;52(6):661–673.
3.
MentzelTBehamACalonjeEKatenkampDFletcherCD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol. 1997;21(4):363–374.
4.
LudwikowskiBJonesN. Epithelioid hemangioendothelioma of external iliac vein with multiple metachronous localizations in liver and lung. Abstracts 9th International Danube-Symposium of Pediatric Surgery; October 21-23, 2005.
5.
DeyrupATTighiouartMMontagAGWeissSW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008;32(6):924–927.
6.
FletcherCD.Epitheliod hemangioendothelioma. Update. Seminars. AFIP. In print. November 2009.
7.
ZhangWHeJWangJ. Ulcerated epithelioid hemangioendothelioma of the right armpit in childhood. J Pediatr Hematol Oncol. 2009;31(8):595–598.
8.
TanselTAydoganUYilmazbayhanDBilgiçBDemiryontMOnursalE. Epitheloid hemangioendothelioma of the heart in infancy. Ann Thorac Surg. 2005;79(4):1402–1405.
9.
MessiasPBernardoJAntunesMJ. Primary left atrial haemangioendothelioma. Interact Cardiovasc Thorac Surg. 2008;7(5):945–946.
10.
MarchianoDFisherFHofstetterS.Epithelioid hemangioendothelioma of the heart with distant metastases. A case report and literature review. J Cardiovasc Surg (Torino). 1993;34(6):529–533.
11.
TraverseJHLesserJRFlygenringBP. Epithelioid hemangioendothelioma of the thoracic aorta resulting in aortic obstruction and congestive heart failure. Circulation. 1999;100(5):564–565.
12.
FerrettiGRChilesCWoodruffRDChoplinRH. Epithelioid hemangioendothelioma of the superior vena cava: computed tomography demonstration and review of the literature. J Thorac Imaging. 1998;13(1):45–48.
13.
Scordi-BelloIASnyderASchwartzMFallonJT. Intravascular epithelioid hemangioendothelioma of the inferior vena cava: case report of an unusual and unpredictable vascular tumor. Cardiovasc Pathol. 2009;18(4):243–246.
14.
NatafPRegnardJFSolvignonFBrunevalPFaucherJNLevasseurP. Epithelioid hemangioendothelioma of the azygos vein [in French]. Arch Mal Coeur Vaiss. 1989;82(11):1919–1922.
15.
CharetteSNehlerMRWhitehillTAGibbsPFoulkDKrupskiWC. Epithelioid hemangioendothelioma of the common femoral vein: case report and review of the literature. J Vasc Surg. 2001;33(5):1100–1103.
16.
ReixTSevestreHSevestri-PietriMASzychtaPPietriJ. Primary malignant tumors of the venous system in the lower extremities. Ann Vasc Surg. 1998;12(6):589–596.
17.
HarrisEJJrTaylorLMJrPorterJM. Epithelioid hemangioendothelioma of the external iliac vein: a primary vascular tumor presenting as traumatic venous obstruction. J Vasc Surg. 1989;10(6):693–699.
18.
DelinAJohanssonGSilfverswärdC. Vascular tumors in occlusive disease of the iliac-femoral vessels. Eur J Vasc Surg. 1990;4(5):539–542.
AkersDLJrCreadoBHewittRL. Iliac vein compression syndrome: case report and review of the literature. J Vasc Surg. 1996;24(3):477–481.
21.
PosniakHVThomasML.Retroperitoneal fibrosis presenting with venous obstruction: a phlebographic and computed tomography study. A report of two cases.Australas Radiol. 1984;28(2):128–132.
22.
SugiuraMKomiyamaTAkagiDMiyataTShigematsuH. Compression of the iliac vein by a synovial cyst. Ann Vasc Surg. 2004;18(3):369–371.
23.
MonrealMESalvadorRCallejasJMMartorellALisbonaC. Compression of the iliac vein and occult neoplasm [in Spanish]. Angiologia. 1989;41(5):185–187.
24.
LouailBVautier-RodaryRGondry-JouetC. Value of imaging in early diagnosis of peripheral vein tumors. J Radiol. 1998;79(11):1387–1389.
25.
LabropoulosNBorgeMPierceKPappasPJ. Criteria for defining significant central vein stenosis with duplex ultrasound. J Vasc Surg. 2007;46(1):101–107.
26.
LouailBVautier-RodaryRGondry-JouetC. Value of imaging in early diagnosis of peripheral vein tumors. J Radiol. 1998;79(11):1387–1391.
KugaiT. Epithelioid hemangioendothelioma of the remnant femoral vein associated with a persistent sciatic vein. Jpn J Vasc Surg. 2006;15:387–390.
30.
ForauerARGemmeteJJDasikaNLChoKJWilliamsDM.Intravascular ultrasound in the diagnosis and treatment of iliac vein compression (May-Thurner) syndrome.J Vasc Interv Radiol. 2002;13(5):523–527.
