Lower extremity claudication most commonly results from atherosclerotic disease. Cystic adventitial disease of the popliteal artery is a rare entity that also manifests with symptoms of claudication. The disease usually occurs in otherwise healthy men without cardiovascular risk factors for atherosclerosis. Extrinsic compression of the arterial lumen leads to arterial insufficiency in these patients. A fairly typical case of cystic adventitial disease of the popliteal artery is reported and a review of the literature is presented.
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