Molecular Biosafety

Alexander I. , Russell D. , & Miller A. (1994). DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. J. Virol., 68(12), 8282–8287.

Astuti D. , Latif F. , Wagner K. , Gentle D. , Cooper W. & Grundy R. (2005). Epigenetic alteration at the DLK1-GTL-2 imprinted domain in human neoplasia: Analysis of neuroblastoma, phaechromocytoma and Wilms tumor. Br J Cancer, 92, 1574–1580.

Bell P. , Moscioni A. , McCarter R. , Wu D. , Gao G. & Hoang A. (2006). Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver. Mol. Ther., 14(1), 34–44.

Bell P. , Wang L. , Lebherz C. , Flieder D. , Bove M. & Wu D. (2005). No evidence for tumorigenesis of AAV vectors in a large-scale study in mice. Mol. Ther., 12(2), 299–306.

Burguete T. , Rabreau M. , Fontanges-Darriet M. , Roset E. , Hager H. & Koppel A. (1999). Evidence for infection of the human embryo with adeno-associated virus in pregnancy. Hum. Reprod., 14(9), 2396–2401.

Donsante A. , Miller D. , Li Y. , Vogler C. , Brunt E. & Russell D. (2007). AAV vector integration sites in mouse hepatocellular carcinoma. Science, 317, 477.

Donsante A. , Vogler C. , Muzyczka N. , Crawford J. , Barker J. & Flotte T. (2001). Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Therapy, 8, 1343–1346.

Dutheil N. , Malhomme O. , Provost N. , Becquart P. , Burgutte T. & Schlehofer J. (1997). Presence of integrated DNA sequences of adeno-associated virus type 2 in four cell lines of human embryonic origin. J. Gen. Virol., 78(Pt. 11), 3039–3043.

Erles K. , Rohde V. , Thaele M. , Roth S. , Edler L. , & Schlehofer J. (2001). DNA of adeno-associated virus (AAV) in testicular tissue and in abnormal semen samples. Hum. Reprod., 16(11), 2333–2337.

Hamilton H. , Gomos J. , Berns K. , & Falck-Pedersen E. (2004). Adeno-associated virus site-specific integration and AAVS1 disruption. J. Virol., 78(15), 7874–7882.

Kawakami T. , Chano T. , Minami K. , Okabe H. , Okada Y. , & Okamoto K. (2006). Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum. Mol. Genet., 15(6), 821–830.

Kay M. A. (2007). AAV vectors and tumorigenicity. Nat. Biotechnol., 25(10), 111–1113.

Kearns W. , Aflone S. , Fulmer S. , Pang M. , Erikson D. & Egan M. (1996). Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Therapy, 3(9), 748–755.

Kiehl K. , Shlehofer J. , Schultz R. , Zugaib M. , & Armbruster-Moraes E. (2002). Adeno-associated virus DNA in human gestational trophoblastic disease. Placenta, 23(5), 410–415.

Mehrle S. , Rohde V. , & Shlehofer J. (2004). Evidence of chromosomal integration in human testis tissue. Virus Genes, 28(1), 61–69.

Meyers C. , Mane M. , Kokorina N. , Alam S. , & Hermona P. (2000). Ubiquitous human adeno-associated virus type 2 autonomously replicates in differentiating keratinocytes of a normal skin model. Virology, 272, 338–346.

Miller D. , Petek L. , & Russell D. (2004). Adeno-associated virus vectors integrate at chromosome breakage sites. Nat. Genet., 36(7), 767–773.

Miller D. , Rutledge E. , & Russell D. (2002). Chromosomal effects of adeno-associated virus vector integration. Nat. Genet., 30(2), 147–148.

Miller D. , Trobridge G. , Petek L. , Jacobs M. , Kaul R. , & Russell D. (2005). Large-scale analysis of adeno-associated virus vector integration sites in normal cells. J. Virol., 79(17), 11434–11442.

Nakai H. , Montini E. , Fuess S. , Storm T. , Grompe M. , & Kay M. (2003). AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat. Genet., 34, 297–302.

Nakai H. , Wu X. , Fuess S. , Storm T. , Munroe D. & Montini E. (2005). Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J. Virol., 79(6), 3606–3614.

Peng D. , Qian C. , Sun Y. , Barajas M. , & Prieto J. (2000). Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): In vitro and in vivo effects of genotoxic agents. J. Hepatol., 32(6), 975–985.

Russell D. (2003). AAV loves an active genome. Nat. Genet., 34, 241–242.

Russell D. , Alexander I. , & Miller A. (1995). DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc. Natl. Acad. Sci. USA, 92, 5719–5723.

Song S. , Lu Y. , Choi Y. , Han Y. , Tang Q. & Berns K. (2003). DNA-dependent PK inhibits adeno-associated virus DNA integration. Proc. Natl. Acad. Sci. USA, 101(7), 2112–2116.