In this paper, a description of olfactory anatomy is presented, followed by a brief
review of modern procedures for testing olfactory function. Information from the sole
study which has quantitatively examined olfactory function in patients with apparent
multiple chemical sensitivity (MCS) is presented. In essence, this study suggests that MCS
is associated with increased nasal airflow resistance, respiration rate, heart rate, and
scores on the Beck Depression Inventory, but not with significant changes in odor
detection threshold sensitivity to phenyl ethyl alcohol and methyl ethyl ketone, the two
target stimuli evaluated. Whether MCS patients evidence hypersensitivity to other
chemicals is unknown.
AMOORE, J.E. and OLLMAN, B.G.
(1983). Practical test kits for quantitatively evaluating
the sense of smell. Rhinology21:
4954.
2.
BLACKWELL, H.R. (1953).
Psychological thresholds: Experimental studies of methods of
measurement. Bulletin of the Engineering Research Institute No. 36,
University of Michigan Press, Ann
Arbor.
BREIPOHL, W., MacKAY-SIM, A.,
GRANDT,
D., REHN, B., and DARRELMANN, C.
(1986). Neurogenesis in the vertebrate main olfactory
epithelium. In: Ontogeny of Olfaction (W. Breipohl, ed.).
Springer-Verlag, Berlin,
pp. 2133.
5.
CAIN, W.S., GENT, J.P.,
GOODSPEED,
R.B., and LEONARD, G. (1988).
Evaluation of olfactory dysfunction in the Connecticut Chemosensory
Clinical Research Center.
Laryngoscope98:
8388.
6.
CHEESMAN, G.H. and TOWNSEND, M.J.
(1956). Further experiments on the olfactory thresholds of
pure chemical substances, using the sniff-bottle method. Q. J.
Exp. Psychol.8:
814.
7.
COLE, P. (1982).
Upper respiratory airflow. In: The Nose: Upper
Airway Physiology and the Atmospheric Environment. (D. Proctor and
I.
Andersen, eds.). Elsevier Biomedical
Press, Amsterdam, pp.
163189.
8.
CORNSWEET, T.N. (1962).
The staircase-method in psychophysics. Am. J.
Psychol.75:
485491.
9.
CULLEN, M.R., ed.
(1987). Workers with multiple chemical
hypersensitivities. State Art Rev. Occup.
Med.2: 655806.
10.
DEEMS, D.A. and DOTY, R.L.
(1987). The nature of age-related olfactory detection
threshold changes in man. Trans. Penn. Acad. Opthalmol.
Otolargyngol.39:
646650.
11.
DEEMS, D.A., DOTY, R.L.,
SETTLE,
R.G., MOORE-GILLION, V., SHAMAN, P.,
MESTER,
A.F., KIMMELMAN, C.P., BRIGHTMAN, V.J.,
and SNOW, J.B.,
Jr. (1991). Smell and taste
disorders: A study of 750 patients from the University of Pennsylvania Smell and Taste
Center. Arch. Otolaryngol. Head Neck
Surg.117:
519528.
DOTY, R.L. (1991).
Olfactory dysfunction in neurodegenerative disorders. In:
Smell and Taste in Health and Disease (T.V. Getchell,
R.L.
Doty, L.M. Bartoshuk, and J.B. Snow, eds.).
Raven Press, N.Y. pp.
735751.
14.
DOTY, R.L. (1992).
Diagnostic tests and assessment. J. Head Trauma
Rehab.7: 4564.
15.
DOTY, R.L., ed. (1995).
Handbook of Olfaction and Gustation. Marcel
Dekker, N.Y.
16.
DOTY, R.L. and KOBAL, G.
(1995). Current trends in the measurement of olfactory
function. In: Handbook of Olfaction and Gustation
(R.L.
Doty, ed.). Marcel Dekker,
N.Y. pp.
191225.
17.
DOTY, R.L., BRUGGER, W.E.,
JURS,
P.C., ORNDORFF, M.A., SNYDER, P.J., and
LOWRY,
L.D. (1978). Intranasal
trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and
normal humans. Physiol. Behav.20:
175185.
18.
DOTY, R.L., SHAMAN, P., and
DANN,
M. (1984a). Development of the
University of Pennsylvania Smell Identification Test: A standardized microencapsulated
test of olfactory function. Physiol. Behav.
(Monograph)32:
489502.
19.
DOTY, R.L., SHAMAN, P.,
APPLEBAUM,
S.L., GIBERSON, R., SIKORSKI, L., and
ROSENBERG,
L. (1984b). Smell
identification ability: Changes with age.
Science226:
14411443.
20.
DOTY, R.L., GREGOR, T., and
SETTLE,
R.G. (1986). Influences of
interval and sniff bottle volume on the phenyl ethyl alcohol olfactory detection
threshold. Chemical Senses11:
259264.
21.
DOTY, R.L., DEEMS, D.A., and
STELLAR,
S. (1988a). Olfactory
dysfunction in Parkinson's Disease: A general deficit unrelated to neurologic signs,
disease stage, or disease duration.
Neurology38:
12371244.
22.
DOTY, R.L., DEEMS, D.A.,
FRYE,
R., PELBERG, R., and SHAPIRO, A.
(1988b). Olfactory sensitivity, nasal resistance, and
autonomic function in multiple chemical sensitivities (MCS) syndrome.
Arch. Otolaryngol.: Head Neck Surg.114:
14221427.
23.
DOTY, R.L., McKEOWN, D.A., and SHAMAN, P. (1994a).
Test-retest reliability of 10 olfactory tests. Submitted.
24.
DOTY, R.L., SMITH R.,
McKEOWN,
D., and RAJ, J. (1994b).
Tests of human olfactory function: Principal components analysis suggests
that most measure a common source of variance. Percept.
Psychophys. In press.
25.
GETCHELL, T.V., DOTY, R.L.,
BARTOSHUK,
L.M., and SNOW, J.B, Jr., Eds. (1991).
Smell and Taste in Health and Disease. Raven
Press, N.Y.
26.
GREER, C.A. (1991).
Structural organization of the olfactory system. In:
Smell and Taste in Health and Disease (T.V. Getchell,
R.L.
Doty, L.M. Bartoshuk, and J.B. Snow, Jr.,
eds.). Raven Press, N.Y.
pp. 6581.
27.
HENKIN, R.I. and BARTTER, F.C.
(1966). Studies of olfactory thresholds in normal man and in
patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and
of serum concentration. J. Clin.
Invest.45:
16311639.
28.
HENKIN, R.I. and POWELL, G.F.
(1962). Increased sensitivity of taste and smell in cystic
fibrosis. Science138:
1107.
29.
HERTZ, J., CAIN, W.S.,
BARTOSHUK,
L.M., and DOLAN, T.F., Jr. (1975).
Olfactory and taste sensitivity in children with cystic
fibrosis. Physiol. Behav.14:
8995.
30.
HINDS, J.W., HINDS, P.L., and
McNELLY,
N.A. (1984). An
autoradiographic study of the mouse olfactory epithelium: evidence of long lived
receptors. Anat. Rec.210:
375383.
31.
HURTT, M.E., THOMAS, D.A.,
WORKING,
P.K., MONTICELLO, T.M., and MORGAN, K.T.
(1988). Degeneration and regeneration of the olfactory
epithelium following inhalation exposure to methyl bromide: Pathology, cell kinetics,
and olfactory function. Toxicol. Appl.
Pharmacol.94:
311328.
32.
MATULIONIS, D.H. (1982).
Effects of the aging process on olfactory neuron
plasticity. In: Olfaction and Endocrine Regulation
(W.
Breipohl, ed.). IRL Press,
London, pp.
299308.
33.
MEGGS, W.J. and CLEVELAND, C.H.
(1993). Rhinolaryngoscopic examination of patients with MCS
syndrome. Arch. Environ. Health48:
1418.
34.
MORAN, D.T., ROWLEY, C.,
III,
and JAFEK,
B. (1991). Anatomy of the human
olfactory epithelium. In: The Human Sense of Smell
(D.G.
Laing, R.L. Doty, and W. Breipohl, eds.).
Springer-Verlag,
Amsterdam, pp.
328.
35.
POWELL, T.P.S. and COWAN, W.M.
(1963). Centrifugal fibers in the lateral olfactory
tract. Nature199:
12961297.
36.
POWELL, T.P.S., COWAN, W.M., and
RAISMAN,
G. (1965). The central
olfactory connections. J. Anat.99:
791813.
37.
PRICE, J.L. (1987).
The central and accessory olfactory systems. In:
Neurobiology of Taste and Smell (T.E. Finger and
W.S.
Silver, eds.). John Wiley,
New York. pp.
179204.
38.
RANDOLPH, T.G. and MOSS, R.W.
(1980). An Alternative Approach to Allergies.
Lippincott and Crowell, New
York.
39.
REHN, B., BREIPOHL, W.,
MENDOZA,
A.S., and APFELBACH, R. (1986).
Changes in granule cells of the ferret olfactory bulb associated with
imprinting on prey odours. Brain
Res.373:
114125.
40.
SCOTT, J.W. and HARRISON, T.A.
(1986). The olfactory bulb: anatomy and
physiology. In: Neurobiology of Taste and Smell
(T.E.
Finger and W.L. Silver, eds.). Wiley
and Sons, New York. pp.
151178.
41.
SERBY, M.J. and CHOBER, K.L., eds.
(1992). Science and Olfaction.
Springer-Verlag, New
York.
42.
SHIPLEY, M.T. and REYES, P.
(1991). Anatomy of the human olfactory bulb and central
olfactory pathways. In: The Human Sense of Smell
(D.G.
Laing, R.L. Doty, and W. Breipohl, eds.).
Springer-Verlag,
Amsterdam, pp.
2960.
43.
SILVER, W.S. (1987).
The common chemical sense. In: Neurobiology of
Taste and Smell (T.E.
Finger and W.L. Silver, eds.). Wiley
and Sons, New York. pp.
6587.
44.
SWIFT, D.L. and PROCTOR, D.F.
(1977). Access of air to the respiratory
tract. In: Respiratory Defense Mechanisms
(J.D.
Brian, D.F. Proctor, and L.M. Reid, eds.).
Marcel Dekker, Inc., New
York. pp. 6393.
45.
TOYOTA, B., KITAMURA, T., and
TAKAGI,
S.F. (1978). Olfactory Disorders,
Olfactometry and Therapy. Igaku-Shoin, Ltd.,
Tokyo.
46.
WARWICK, R. and WILLIAMS, P.L.
(1973). Gray's Anatomy.
Saunders,
Philadelphia.
47.
WEIFFENBACH, J.M. and McCARTHY, V.P.
(1984). Olfactory deficits in cystic fibrosis: Distribution
and severity. Chem. Senses9:
193199.
