Autophagy is a self-digestion process by which misfolded proteins and damaged organelles in eukaryotic cells are degraded to maintain cellular homeostasis. This process is involved in the tumorigenesis, metastasis, and chemoresistance of various tumors such as ovarian cancer (OC). Noncoding RNAs (ncRNAs), mainly including microRNAs, long noncoding RNAs, and circular RNAs, have been extensively investigated in cancer research for their roles in the regulation of autophagy. Recent studies have shown that in OC cells, ncRNAs can modulate the formation of autophagosomes, which affect tumor progression and chemoresistance. An understanding of the role of autophagy in OC progression, treatment, and prognosis is important, and the identification of the regulatory roles of ncRNAs in autophagy leads to intervention strategies for OC therapy. This review summarizes the role of autophagy in OC and discusses the role of ncRNA-mediated autophagy in OC, as an understanding of these roles may contribute to the development of potential therapeutic strategies for this disease.
SungHFerlayJSiegelRLLaversanneMSoerjomataramIJemalABrayF.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J Clin2021;71:209–49
2.
CortezAJTudrejPKujawaKALisowskaKM.Advances in ovarian cancer therapy.Cancer Chemother Pharmacol2018;81:17–38
3.
MorishitaHMizushimaN.Diverse cellular roles of autophagy.Annu Rev Cell Dev Biol2019;35:453–75
4.
XiaHGreenDRZouW.Autophagy in tumour immunity and therapy.Nat Rev Cancer2021;21:281–97
5.
GalluzziLGreenDR.Autophagy-independent functions of the autophagy machinery.Cell2019;177:1682–99
6.
AmaravadiRKKimmelmanACDebnathJ.Targeting autophagy in cancer: recent advances and future directions.Cancer Discov2019; 9:1167–81
7.
ZhanLZhangYWangWSongEFanYLiJWeiB.Autophagy as an emerging therapy target for ovarian carcinoma.Oncotarget2016;7: 83476–87
8.
YinQFengWShenXJuS.Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis.Biosci Rep. Epub ahead of print 23October2018. DOI: 10.1042/BSR20180516
9.
de la Cruz-OjedaPFlores-CamposRNavarro-VillaranEMuntaneJ.The role of non-coding RNAs in autophagy during carcinogenesis.Front Cell Dev Biol2022;10:799392
10.
HuZCaiMZhangYTaoLGuoR.miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway.Cell Cycle2020;19:193–206
11.
WangXLiXLinFSunHLinYWangZWangX.The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis.J Exp Clin Cancer Res2021;40:151
12.
ZhangZZhuHHuJ.CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.Cell Death Dis2021;12:219
13.
LiXHeSMaB.Autophagy and autophagy-related proteins in cancer.Mol Cancer2020;19:12
14.
ShenYLiDDWangLLDengRZhuXF.Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer.Autophagy2008;4:1067–8
15.
ZhaoZXueJZhaoXLuJLiuP.Prognostic role of autophagy-related proteins in epithelial ovarian cancer: a meta-analysis of observational studies.Minerva Med2017;108:277–86
16.
SpowartJETownsendKNHuwaitHEshraghSWestNRRiesJNKallogerSAnglesioMGorskiSMWatsonPHGilksCBHuntsmanDGLumJJ.The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer.J Pathol2012;228:437–47
17.
MiyamotoMTakanoMAoyamaTSoyamaHYoshikawaTTsudaHFuruyaK.Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas.J Gynecol Oncol2017;28:e33
18.
ValenteGMoraniFNicotraGFuscoNPeracchioCTitoneRAlabisoOArisioRKatsarosDBenedettoCIsidoroC.Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer.Biomed Res Int2014;2014:462658
19.
BerkampSMostafaviSSachseC.Structure and function of p62/SQSTM1 in the emerging framework of phase separation.FEBS J2021;288:6927–41
20.
WangJGarbuttCMaHGaoPHornicekFJKanQShiHDuanZ.Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.Gynecol Oncol2018;150:143–50
21.
IwadateRInoueJTsudaHTakanoMFuruyaKHirasawaAAokiDInazawaJ.High expression of SQSTM1/p62 protein is associated with poor prognosis in epithelial ovarian cancer.Acta Histochem Cytochem2014;47:295–301
22.
YanXYZhongXRYuSHZhangLCLiuYNZhangYSunLKSuJ.p62 aggregates mediated caspase 8 activation is responsible for progression of ovarian cancer.J Cell Mol Med2019;23:4030–42
23.
KongQYanXChengMJiangXXuLShenLYuHSunL.p62 promotes the mitochondrial localization of p53 through its UBA domain and participates in regulating the sensitivity of ovarian cancer cells to cisplatin.Int J Mol Sci2022;23:3290.
24.
Vega-Rubín-de-CelisS.The role of Beclin 1-dependent autophagy in cancer.Biology2019;9:4
25.
MaJLiuLLingYZhengJ.Polypeptide LTX-315 reverses the cisplatin chemoresistance of ovarian cancer cells via regulating Beclin-1/PI3K/mTOR signaling pathway.J Biochem Mol Toxicol2021;35:e22853
26.
ZhaoYChenSGouWFXiaoLJTakanoYZhengHC.Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma.Tumour Biol2014;35:1955–64
27.
CaiMHuZLiuJGaoJLiuCLiuDTanMZhangDLinB.Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis.Int J Mol Sci2014;15:5292–303
28.
JuLLZhaoCYYeKFYangHZhangJ.Expression and clinical implication of Beclin1, HMGB1, p62, survivin, BRCA1 and ERCC1 in epithelial ovarian tumor tissues.Eur Rev Med Pharmacol Sci2016;20:1993–2003
29.
LinHXQiuHJZengFRaoHLYangGFKungHFZhuXFZengYXCaiMYXieD.Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma.PLoS ONE2013;8:e60516
30.
AlabiadMHarbOMandourDHemedaRAhmedRZEl-TaherAOsmanGShalabyAAlnemrAAAAbdelfattahMT.Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study.Pol J Pathol2021;72:23–38
31.
KatagiriHNakayamaKRaziaSNakamuraKSatoEIshibashiTIshikawaMIidaKIshikawaNOtsukiYNakayamaSKyoS.Loss of autophagy-related protein Beclin 1 may define poor prognosis in ovarian clear cell carcinomas.Int J Oncol2015;47:2037–44
32.
MinamotoTNakayamaKNakamuraKKatagiriHSultanaRIshibashiTIshikawaMYamashitaHSanukiKIidaKNakayamaSOtsukiYIshikawaNKyoS.Loss of beclin 1 expression in ovarian cancer: a potential biomarker for predicting unfavorable outcomes.Oncol Lett2018;15:1170–6
33.
LiuMBamoduOAHuangWCZuchaMALinYKWuATHHuangCCLeeWHYuanCCHsiaoMDengLTzengYMYehCT.4-acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway.Toxicol Appl Pharmacol2017;325:48–60
34.
ZhaoYWangWPanWYuYHuangWGaoJZhangYZhangS.WWOX promotes apoptosis and inhibits autophagy in paclitaxel‑treated ovarian carcinoma cells.Mol Med Rep2021;23:115
35.
DaiFZhangYChenY.Involvement of miR-29b signaling in the sensitivity to chemotherapy in patients with ovarian carcinoma.Hum Pathol2014;45:1285–93
36.
AnYBiFYouYLiuXYangQ.Development of a novel autophagy-related prognostic signature for serous ovarian cancer.J Cancer2018; 9:4058–71
37.
NiuYSunWChenKFuZChenYZhuJChenHShiYZhangHWangLShenHMXiaDWuY.A novel scoring system for pivotal autophagy-related genes predicts outcomes after chemotherapy in advanced ovarian cancer patients.Cancer Epidemiol Biomarkers Prev2019;28:2106–14
38.
FeiHChenSXuC.Construction autophagy-related prognostic risk signature to facilitate survival prediction, individual treatment and biomarker excavation of epithelial ovarian cancer patients.J Ovarian Res2021;14:41
39.
du RusquecPBlonzCFrenelJSCamponeM.Targeting the PI3K/Akt/mTOR pathway in estrogen-receptor positive HER2 negative advanced breast cancer.Ther Adv Med Oncol. Epub ahead of print 28July2020. DOI: 10.1177/1758835920940939
40.
YuYHouLSongHXuPSunYWuK.Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells.Mol Cell Biochem2017;424:173–83
41.
ZhuHDiaoSLimVHuLHuJ.FAM83D inhibits autophagy and promotes proliferation and invasion of ovarian cancer cells via PI3K/AKT/mTOR pathway.Acta Biochim Biophys Sin2019;51:509–16
42.
HuangJGaoLLiBLiuCHongSMinJHongL.Knockdown of hypoxia-inducible factor 1α (HIF-1α) promotes autophagy and inhibits phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in ovarian cancer cells.Med Sci Monit2019;25:4250–63
43.
HuXXiaMWangJYuHChaiJZhangZSunYSuJSunL.Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy.Biomed Pharmacother2020;129:110397
44.
ZhouJJiangYYChenHWuYCZhangL.Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway.Cell Prolif2020;53:e12739
45.
RonkinaNGaestelM.MAPK-activated protein kinases: servant or partner?Annu Rev Biochem2022;91:505–40
46.
ChengCYTsengHHChiuHCChangCDNielsenBLLiuHJ.Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway.Vet Res2019;50:79
47.
Hernández-PadillaLReyes de la CruzHCampos-GarcíaJ.Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner.Apoptosis2020;25:632–47
48.
XieCMTanMLinXTWuDJiangYTanYLiHMaYXiongXSunY.The FBXW7-SHOC2-raptor axis controls the cross-talks between the RAS-ERK and mTORC1 signaling pathways.Cell Rep2019;26:3037–504
49.
LiMZhaoXYongHShangBLouWWangYBaiJ.FBXO22 promotes growth and metastasis and inhibits autophagy in epithelial ovarian cancers via the MAPK/ERK pathway.Front Pharmacol2021;12:778698
50.
LimVZhuHDiaoSHuLHuJ.PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.Biochem Biophys Res Commun2019;508:646–53
51.
LiangFRenCWangJWangSYangLHanXChenYTongGYangG.The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy.Oncogenesis2019;8:59
52.
ChenXChenYLinXSuSHouXZhangQTianY.The drug combination of SB202190 and SP600125 significantly inhibit the growth and metastasis of olaparib-resistant ovarian cancer cell.Curr Pharm Biotechnol2018;19:506–13
53.
BakulaDMuellerAJProikas-CezanneT.WIPI beta-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy.Autophagy2018;14:1082–3
54.
Barroso-ChineaPLuis-RaveloDFumagallo-ReadingFCastro-HernandezJSalas-HernandezJRodriguez-NunezJFebles-CasqueroACruz-MurosIAfonso-OramasDAbreu-GonzalezPMoratallaRMillanMJGonzalez-HernandezT.DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.Autophagy2020;16:1279–95
55.
MercerTJToozeSA.The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics.Autophagy2021;17: 4491–3
56.
LaskiJSinghaBWangXValdésYRCollinsOShepherdTG.Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis.J Ovarian Res2020;13:58
57.
CheLYangXGeCEl-AmouriSSWangQEPanDHerzogTJDuC.Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis.PLoS ONE2019;14:e0216553
58.
FanXXieMZhaoFLiJFanCZhengHWeiZCiXZhangS.Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer.Phytomedicine2021;82:153465
59.
ElsaidFGAlshehriMAShatiAAAl-KahtaniMAAlsheriASMassoudEEEl-KottAFEl-MekkawyHIAl-RamlawyAMAbdrabohME.The anti-tumourigenic effect of ellagic acid in SKOV-3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK.Clin Exp Pharmacol Physiol2020;47:1611–21
60.
ParkJHKunduALeeSHJiangCLeeSHKimYSKyungSYParkSHKimHS.Specific pyruvate kinase M2 inhibitor, compound 3K, induces autophagic cell death through disruption of the glycolysis pathway in ovarian cancer cells.Int J Biol Sci2021;17:1895–908
61.
HafnerABulykMLJambhekarALahavG.The multiple mechanisms that regulate p53 activity and cell fate.Nat Rev Mol Cell Biol2019;20:199–210
62.
GaoALiFZhouQChenL.Sestrin2 as a potential therapeutic target for cardiovascular diseases.Pharmacol Res2020;159:104990
63.
Chollat-NamyMBen Safta-SaadounTHaferssasDMeuriceGChouaibSThieryJ.The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.Cell Death Dis2019;10:695
64.
KongDMaSLiangBYiHZhaoYXinRCuiLJiaLLiuXLiuX.The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells.Biomed Pharmacother2012;66:271–8
65.
ParkGBJeongJYKimD.Gliotoxin enhances autophagic cell death via the DAPK1-TAp63 signaling pathway in paclitaxel-resistant ovarian cancer cells.Mar Drugs2019;17:412
66.
ZhangXQiZYinHYangG.Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.Theranostics2019;9:1096–114
67.
FolkertsHHilgendorfSVellengaEBremerEWiersmaVR.The multifaceted role of autophagy in cancer and the microenvironment.Med Res Rev2019;39:517–60
68.
FerraresiAGironeCEspositoAVidoniCVallinoLSecomandiEDhanasekaranDNIsidoroC.How autophagy shapes the tumor microenvironment in ovarian cancer.Front Oncol2020;10:599915
69.
SinghaBLaskiJRamos ValdésYLiuEDiMattiaGEShepherdTG.Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids.Am J Cancer Res2020;10:1384–99
70.
WangYRenYLiNZhaoJZhaoS.Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.Genes Genomics2022;44:1375–84
71.
ZhaoSFanSShiYRenHHongHGaoXZhangMQinQLiH.Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in human ovarian cancer.J Cancer2020;11:5900–10
72.
LuanWPangYLiRWeiXJiaoXShiJYuJMaoHLiuP.Akt/mTOR-mediated autophagy confers resistance to BET inhibitor JQ1 in ovarian cancer.Onco Targets Ther2019;12:8063–74
73.
SalviAYoungANHuntsmanACPergandeMRKorkmazMARathnayakeRAMizeBKKinghornADZhangXRatiaKSchirleMThomasJRBrittainSMSheltonCAldrichLNColognaSMFuchsJRBurdetteJE.PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.Cell Death Dis2022;13:45
74.
LiXHuZShiHWangCLeiJChengY.Inhibition of VEGFA increases the sensitivity of ovarian cancer cells to chemotherapy by suppressing VEGFA-mediated autophagy.Onco Targets Ther2020;13: 8161–71
75.
TanWXXuTMZhouZLLvXJLiuJZhangWJCuiMH.TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer.Oncol Rep2019;42:1343–54
76.
MaHLiYWangXWuHQiGLiRYangNGaoMYanSYuanCKongB.PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.Cell Death Dis2019;10:166
77.
QiGMaHLiYPengJChenJKongB.TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway.Cell Death Dis2021;12:1135
78.
RogalskaAGajekAMarczakA.Suppression of autophagy enhances preferential toxicity of epothilone A and epothilone B in ovarian cancer cells.Phytomedicine2019;61:152847
79.
SongXLiuLChangMGengXWangXWangWChenTCXieLSongX.NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer.J Exp Clin Cancer Res2019;38:239
80.
JiangSChangHDengSFanD.Icariin enhances the chemosensitivity of cisplatin‑resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway.Int J Oncol2019;54: 1933–42
81.
YangJPengSZhangK.ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5.Hum Exp Toxicol. Epub ahead of print 10November2022. DOI: 10.1177/0960327122113506
82.
LiYZhouQShenJZhuL.Down-regulation of PSMD4 can attenuate autophagy, enhance the accumulation of intracellular ROS, and increase the sensitivity of epithelial ovarian cancer to carboplatin by inhibiting the NF-kappaB pathway.Transl Cancer Res2021;10:4756–72
83.
VianelloCCocettaVCatanzaroDDornGW2ndDeMilitoARizzolioFCanzonieriVCecchinERoncatoRToffoliGQuagliarielloVDi MauroALositoSMaureaNConoSSalesGScorranoLGiacomelloMMontopoliM.Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy.Cell Death Dis2022;13:398
84.
ZhaoZXuHWeiYSunLSongY. Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.Biochim Biophys Acta Mol Basis Dis2022:166594
85.
HuangWHuangHXiaoYWangLZhangTFangXXiaX.UBE2T is upregulated, predicts poor prognosis, and promotes cell proliferation and invasion by promoting epithelial-mesenchymal transition via inhibiting autophagy in an AKT/mTOR dependent manner in ovarian cancer.Cell Cycle2022;21:780–91
86.
AshrafRKumarS.Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling.Cell Mol Life Sci2022;79:573
87.
LiRLiHLanJYangDLinXXuHHanBYangMSuBLiuFJiangW.Damnacanthal isolated from Morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy.Phytomedicine2022;100:154084
88.
FerraresiAEspositoAGironeCVallinoLSalwaAGhezziIThongchotSVidoniCDhanasekaranDNIsidoroC.Resveratrol contrasts LPA-induced ovarian cancer cell migration and platinum resistance by rescuing hedgehog-mediated autophagy.Cells2021;10:3213.
89.
EspositoAFerraresiASalwaAVidoniCDhanasekaranDNIsidoroC.Resveratrol contrasts IL-6 pro-growth effects and promotes autophagy-mediated cancer cell dormancy in 3D ovarian cancer: role of miR-1305 and of its target ARH-I.Cancers2022;14:2142
90.
YoonSYLindrothAMKwonSParkSJParkYJ.Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death.Biomed Pharmacother2022; 153:113491
91.
LiuFTangLTaoMCuiCHeDLiLLiaoYGaoYHeJSunFLinHLiH.Stichoposide C exerts anticancer effects on ovarian cancer by inducing autophagy via inhibiting AKT/mTOR pathway.Onco Targets Ther2022;15:87–101
92.
WuJLinCChenXPanNLiuZ.Polysaccharides isolated from Bangia fuscopurpurea induce apoptosis and autophagy in human ovarian cancer A2780 cells.Food Sci Nutr2021;9:6707–19
93.
ThirusanguPPathoulasCLRayUXiaoYStaubJJinLKhuranaAShridharV.Quinacrine-induced autophagy in ovarian cancer triggers cathepsin-L mediated lysosomal/mitochondrial membrane permeabilization and cell death.Cancers2021;13:2004
94.
ZhongYLeFChengJLuoCZhangXWuXXuFZuoQTanB.Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells.Oncol Rep2021;45:69.
95.
SunXLiJLiYWangSLiQ.Apatinib, a novel tyrosine kinase inhibitor, promotes ROS-dependent apoptosis and autophagy via the Nrf2/HO-1 pathway in ovarian cancer cells.Oxid Med Cell Longev2020;2020:3145182
96.
LiuBHuangXLiYLiaoWLiMLiuYHeRFengDZhuRKuriharaH.JS-K, a nitric oxide donor, induces autophagy as a complementary mechanism inhibiting ovarian cancer.BMC Cancer2019;19:645
97.
SlackFJChinnaiyanAM.The role of non-coding RNAs in oncology.Cell2019;179:1033–55
98.
LiuQLZhangZWeiXZhouZG.Noncoding RNAs in tumor metastasis: molecular and clinical perspectives.Cell Mol Life Sci2021;78:6823–50
99.
VoJNCieslikMZhangYShuklaSXiaoLZhangYWuYMDhanasekaranSMEngelkeCGCaoXRobinsonDRNesvizhskiiAIChinnaiyanAM.The landscape of circular RNA in cancer.Cell2019;176:869–81.e13
100.
LiangJZhangLChengW.Non-coding RNA-mediated autophagy in cancer: a protumor or antitumor factor?Biochim Biophys Acta Rev Cancer2021;1876:188642
101.
ShaoYLiuXMengJZhangXMaZYangG.MicroRNA-1251-5p promotes carcinogenesis and autophagy via targeting the tumor suppressor TBCC in ovarian cancer cells.Mol Ther2019;27:1653–64
102.
LiYGuYTangNLiuYZhaoZ.MiR-22-notch signaling pathway is involved in the regulation of the apoptosis and autophagy in human ovarian cancer cells.Biol Pharm Bull2018;41:1237–42
103.
HeJYuJJXuQWangLZhengJZLiuLZJiangBH.Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy.Autophagy2015;11:373–84
104.
LiHLeiYLiSLiFLeiJ.MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP1.Reprod Toxicol2022;109:93–100
105.
CaiYAnBYaoDZhouHZhuJ.MicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy.Bioengineered2021;12:10713–22
106.
ZhouYWangCDingJChenYSunYChengZ.MiR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy.Cancer Cell Int2022;22:15
107.
WangYZhangXTangWLinZXuLDongRLiYLiJZhangZLiXZhaoLWeiJJShaoCKongBLiuZ.MiR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-kappaB in high-grade serous ovarian carcinoma.Cell Death Differ2017;24:2089–100
108.
YuJLGaoX.MicroRNA 1301 inhibits cisplatin resistance in human ovarian cancer cells by regulating EMT and autophagy.Eur Rev Med Pharmacol Sci2020;24:1688–96
109.
JiaYLinRJinHSiLJianWYuQYangS.MicroRNA-34 suppresses proliferation of human ovarian cancer cells by triggering autophagy and apoptosis and inhibits cell invasion by targeting Notch 1.Biochimie2019;160:193–9
110.
GaoLLovelessJShayCTengY.Targeting ROS-mediated crosstalk between autophagy and apoptosis in cancer.Adv Exp Med Biol2020;1260:1–12
111.
DasSShuklaNSinghSSKushwahaSShrivastavaR.Mechanism of interaction between autophagy and apoptosis in cancer.Apoptosis2021;26:512–33
112.
HuJZhangLMeiZJiangYYiYLiuLMengYZhouLZengJWuHJiangX.Interaction of E3 ubiquitin ligase MARCH7 with long noncoding RNA MALAT1 and autophagy-related protein ATG7 promotes autophagy and invasion in ovarian cancer.Cell Physiol Biochem2018;47:654–66
113.
YuYZhangXTianHZhangZTianY.Knockdown of long non-coding RNA HOTAIR increases cisplatin sensitivity in ovarian cancer by inhibiting cisplatin-induced autophagy.J BUON2018;23:1396–401
114.
XiaXLiZLiYYeFZhouX.LncRNA XIST promotes carboplatin resistance of ovarian cancer through activating autophagy via targeting miR-506-3p/FOXP1 axis.J Gynecol Oncol2022;33:e81
115.
ChenSWuDDSangXBWangLLZongZHSunKXLiuBLZhaoY.The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma.Cell Death Dis2017;8:e3118
116.
ZouSHDuXSunFDWangPCLiM.Cisplatin suppresses tumor proliferation by inhibiting autophagy in ovarian cancer via long non-coding RNA RP11-135L22.1.Eur Rev Med Pharmacol Sci2018;22:928–35
117.
XiuYLSunKXChenXChenSZhaoYGuoQGZongZH.Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3.Oncotarget2017;8:31714–25
118.
LuoYLiJYuPSunJHuYMengX.Targeting lncRNAs in programmed cell death as a therapeutic strategy for non-small cell lung cancer.Cell Death Discov2022;8:159
119.
MillerDRCramerSDThorburnA.The interplay of autophagy and non-apoptotic cell death pathways.Int Rev Cell Mol Biol2020;352:159–87
120.
GanXZhuHJiangXObiegbusiSCYongMLongXHuJ.CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.Mol Cancer2020;19:45
121.
SongWZengZZhangYLiHChengHWangJWuF.CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1.Cell Death Dis2022;13:857
