Tamarix gallica known as Jhau is traditionally used as expectorant, liver tonic, laxative, astringent, and antidiarrheal. The current study was proposed to determine the in vitro antioxidant, antidiabetic properties of the methanolic, ethanolic, and aqueous extracts of Tamarix gallica arial part, subsequently the phytochemical evaluation. Hence, Tamarix gallica arial part extracts were extracted with methanol (MthTg), ethanol (EthTg), and distilled water (AqTg). Extracts phytochemical analysis were accomplished to identify the phenolic components (TPC and TFC). Extracts antioxidant property was evaluated by DPPH, FRAP, and ABTS assay. For antidiabetic property, α-amylase and α-glucosidase inhibitory activities were assessed. One Way ANOVA was applied statistically by means of software SPSS Statistics 23 and attained data were definite as mean ± standard deviation. Result revealed that EthTg have the maximum TPC and TFC levels than MthTg and AqTg. Antioxidant property in relations of DPPH (lowest IC50 = 1.309 ± 0.31), FRAP (323.51 ± 2.32), and ABTS (266.97 ± 25.14) assay was also highest in EthTg. EthTg was also exposed highest α-amylase and α-glucosidase inhibition activity with lower IC50 (1.116 ± 0.051; 0.402 ± 0.2, respectively). The extracts antioxidant and antidiabetic activities order was as EthTg > MthTg > AqTg. TFC and TPC also revealed directly proportional correlation with antioxidant, and antidiabetic properties of the Tamarix gallica arial part extracts. Results noticeably stated that the ethanolic extract of Tamarix gallica have the highest antioxidant and antidiabetic properties. Tamarix gallica has competency to reduce the oxidative stress and can be utilized in the management of diabetes.
LiguoriIRussoGCurcioFBulliGAranLDella-MorteDGargiuloGTestaGCacciatoreFBonaduceD.Oxidative stress, aging, and diseases.Clin Interv Aging2018;13:757–72
2.
SalisburyDBronasU.Reactive oxygen and nitrogen species: impact on endothelial dysfunction.Nurs Res2015;64(1):53–66
3.
PhaniendraAJestadiDBPeriyasamyL.Free radicals: properties, sources, targets, and their implication in various diseases.Indian J Clin Biochem2015;30(1):11–26
4.
IzzoCVitilloPDi PietroPViscoVStrianeseAVirtuosoNCiccarelliMGalassoGCarrizzoAVecchioneC.The role of oxidative stress in cardiovascular aging and cardiovascular diseases.Life2021;11:60–102
5.
UddinMJKimEHHannanMAHaH.Pharmacotherapy against oxidative stress in chronic kidney disease: promising small molecule natural products targeting nrf2-ho-1 signaling.Antioxidants2021;10:258–84
6.
OrnatowskiWLuQYegambaramMGarciaAEZemskovEAMaltepeEFinemanJRWangTBlackSM.Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.Redox Biol2020;36:101679
7.
ChenZTianRSheZCaiJLiH.Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease.Free Radic Biol Med2020;152:116–41
8.
D’OriaRSchipaniRLeonardiniANatalicchioAPerriniSCignarelliALaviolaLGiorginoF.The role of oxidative stress in cardiac disease: from physiological response to injury factor.Oxid Med Cell Longev2020;2020:5732956
9.
HöhnATramutolaACascellaR.Proteostasis failure in neurodegenerative diseases: focus on oxidative stress.Oxid Med Cell Longev2020; 2020:5497046
10.
ZhangPLiTWuXNiceECHuangCZhangY.Oxidative stress and diabetes: antioxidative strategies.Front Med2020;14(5):583–600
11.
BashanNKovsanJKachkoIOvadiaHRudichA.Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species.Physiol Rev2009;89(1):27–71
12.
BeidokhtiMNJägerAK.Review of antidiabetic fruits, vegetables, beverages, oils and spices commonly consumed in the diet.J Ethnopharmacol2017;201:26–41
13.
MustafaIFaisalMNHussainGMuzaffarHImranMIjazMUSohailMUIftikharAShaukatAAnwarH.Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts.BMC Complement Med Ther2021;21:62
14.
AshaoluTJ.Antioxidative peptides derived from plants for human nutrition: their production, mechanisms and applications.Eur Food Res Technol2020;246:853–65
15.
KolupaevYEKarpetsYVKabashnikovaL.Antioxidative system of plants: cellular compartmentalization, protective and signaling functions, mechanisms of regulation.Appl Biochem Microbiol2019;55:441–59
16.
NisarJMustafaIAnwarHSohailMUHussainGUllahMIFaisalMNBukhariSABasitA.Shiitake culinary-medicinal mushroom, Lentinus edodes (Agaricomycetes): a species with antioxidant, immunomodulatory, and hepatoprotective activities in hypercholesterolemic rats.Int J Med Mushrooms2017;19(11):981–90
17.
UrfiMKMujahidMRahmanMARahmanMA.The role of Tamarix gallica leaves extract in liver injury induced by rifampicin plus isoniazid in Sprague Dawley rats.J Diet Suppl2018;15:24–33
18.
KalamUrfiMMujahidMBadruddeenJKhalidMKhanMUsmaniA.Tamarix gallica: for traditional uses, phytochemical and pharmacological potentials.J Chem Pharm Res2016;8:809–14
19.
ElaminM. A review of biological and pharmacological activities from the aerial part of Tamarisk. G.Int J Pharm Res2016;5:22–36
20.
KsouriRFallehHMegdicheWTrabelsiNMhamdiBChaiebKBakroufAMagnéCAbdellyC. Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents.Food Chem Toxicol2009;47(8):2083–91
21.
BencherifKDjaballahZBrahimiFBoutekrabtADalpèYSahraouiAL-H. Arbuscular mycorrhizal fungi affect total phenolic content and antimicrobial activity of Tamarix gallica in natural semi-arid Algerian areas.S Afr J Bot2019;125:39–45
22.
BettaibJTalarminHDroguetMMagnéCBoulaabaMGiroux-MetgesM-AKsouriR.Tamarix gallica phenolics protect IEC-6 cells against H2O2 induced stress by restricting oxidative injuries and MAPKs signaling pathways.Biomed Pharmacother2017;89:490–8
23.
SinghKLBagG.Phytochemical analysis and determination of total phenolics content in water extracts of three species of Hedychium.Int J Pharmtech Res2013;5:1516–21
24.
KainamaHFatmawatiSSantosoMPapilayaPMErsamT.The relationship of free radical scavenging and total phenolic and flavonoid contents of Garcinia lasoar PAM.Pharm Chem J2020;53:1151–7
25.
BajalanIMohammadiMAlaeiMPirbaloutiAG.Total phenolic and flavonoid contents and antioxidant activity of extracts from different populations of lavandin.Ind Crops Prod2016;87:255–60
26.
SethiSJoshiAAroraBBhowmikASharmaRKumarP.Significance of FRAP, DPPH, and CUPRAC assays for antioxidant activity determination in apple fruit extracts.Eur Food Res Technol2020;246:591–8
27.
AsemNAbdul GaparNAAbd HapitNHOmarEA.Correlation between total phenolic and flavonoid contents with antioxidant activity of Malaysian stingless bee propolis extract.J Apic Res2020;59:437–42
28.
AdebiyiOEOlayemiFONing-HuaTGuang-ZhiZ.In vitro antioxidant activity, total phenolic and flavonoid contents of ethanol extract of stem and leaf of Grewia carpinifolia.Beni-Suef Univ J Basic Appl Sci2017;6:10–4
29.
NisarJShahSMAAkramMAyazSRashidA.Phytochemical screening, antioxidant, and inhibition activity of Picrorhiza kurroa against α-amylase and α-glucosidase.Dose Response2022;20:1–12
30.
ShamimSRehmanA.Antioxidative enzyme profiling and biosorption ability of Cupriavidus metallidurans CH34 and Pseudomonas putida mt2 under cadmium stress.J Basic Microbiol2015;55(3):374–81
31.
PrasannaGDeviRIshwaryaG. In vitro evaluation of antidiabetic and cytotoxicity potentials of the rhizome extract of Drynaria quercifolia (L.) J. Smith.Asian J Pharm Clin Res2019;12:72–6
32.
SundarrajanTVelmuruganVSrimathiR.Phytochemical evaluation and in vitro antidiabetic activity of ethanolic extract of alternanthera ficodia linn.Res J Pharm Technol2017;10:2981–3
33.
TrendowskiM.Recent advances in the development of antineoplastic agents derived from natural products.Drugs2015;75(17):1993–2016
34.
FridlenderMKapulnikYKoltaiH.Plant derived substances with anti-cancer activity: from folklore to practice.Front Plant Sci2015;6:799
35.
PengellyABoneK.The constituents of medicinal plants: an introduction to the chemistry and therapeutics of herbal medicine. London: Routledge, 2020, pp.1–184
36.
TliliNElfallehWHannachiHYahiaYKhaldiAFerchichiANasriN.Screening of natural antioxidants from selected medicinal plants.Int J Food Prop2013;16:1117–26
37.
GülçinİBingölZTaslimiPGörenACAlwaselSHTelAZ. Polyphenol contents, potential antioxidant, anticholinergic and antidiabetic properties of mountain mint (Cyclotrichium leucotrichum).Chem Biodivers2022;19(3):e202100775
38.
AlfarrayehITarawnehKAlmajaliDAl-AwaidaW.Evaluation of the antibacterial and antioxidant properties of the methanolic extracts of four medicinal plants selected from Wadi Al-Karak/Jordan related to their phenolic contents.Res J Pharm Technol2022;15:2110–6
39.
AyeleDTAkeleMMeleseA.Analysis of total phenolic contents, flavonoids, antioxidant and antibacterial activities of Croton macrostachyus root extracts.BMC Chem2022;16:30
40.
BursalETaslimiPGörenACGülçinİ.Assessments of anticholinergic, antidiabetic, antioxidant activities and phenolic content of Stachys annua.Biocatal Agric Biotechnol2020;28:101711
RoseroSDel PozoFSimbañaWÁlvarezMQuinterosMFCarrilloWMoralesD.Polyphenols and flavonoids composition, anti-inflammatory and antioxidant properties of Andean Baccharis macrantha extracts.Plants2022;11:1555–74
43.
Vo VanLPhamECNguyenCVDuongNTNVi Le ThiTTruongTN. In vitro and in vivo antidiabetic activity, isolation of flavonoids, and in silico molecular docking of stem extract of Merremia tridentata (L.).Biomed Pharmacother2022;146:112611
44.
AneshwariRKYadavKBanjaraRAKumarAKujurAJainV.Standardization and comparative evaluation of phytochemical content and antioxidant activity of Alocasia indica and Tephrosia purpurea.Int J Health Sci2022;6:2241–51
45.
AhmadSRGhoshP.A systematic investigation on flavonoids, catechin, β-sitosterol and lignin glycosides from Saraca asoca (ashoka) having anti-cancer & antioxidant properties with no side effect.J Indian Chem Soc2022;99:100293–303
46.
ElaminMM.Solvent extraction and spectroscopy identification of bioactive compounds from medicinal shrub Tamarix gallica.Funct Foods Health Dis2020;10:456–64
47.
SaidSNoureddineGEddineLSAbdelmadjidGDjamelBTlibaA.Phenolic content, HPLC analysis and antioxidant activity extract from Tamarix gallica and Tamarix articulata growing in Southeast of Algeria.Res J Pharm Technol2018;11:3826–32
48.
BoulaabaMSnoussiMSaadaMMkadminiKSmaouiAAbdellyCKsouriR.Antimicrobial activities and phytochemical analysis of Tamarix gallica extracts.Ind Crops Prod2015;76:1114–22
49.
DrabuSChaturvediSSharmaM.Antioxidant activity, total phenolic, and flavonoid content of aerial parts of Tamarix gallica.Int J Phytomedicine2012;4:174–80
50.
PisoschiAMPopAIordacheFStancaLPredoiGSerbanAI. Oxidative stress mitigation by antioxidants-an overview on their chemistry and influences on health status.Eur J Med Chem2021;209:112891
51.
SalehiBAzziniEZuccaPMaria VaroniEAnil KumarNVDiniLPanzariniERajkovicJValere Tsouh FokouPPelusoIMishraAPNigamMEl RayessYEl BeyrouthyMSetzerWNPolitoLIritiMSuredaAQuetglas-LlabrésMMMartorellMMartinsNSharifi-RadMEstevinhoLMSharifi-RadJ.Plant-derived bioactives and oxidative stress-related disorders: a key trend towards healthy aging and longevity promotion.Appl Sci2020;10:947–73
52.
Jamshidi-KiaFWibowoJPElachouriMMasumiRSalehifard-JouneghaniAAbolhasanzadehZLorigooiniZ.Battle between plants as antioxidants with free radicals in human body.J Herbmed Pharmacol2020;9:191–9
53.
LefahalMMakhloufiEHTrifaWAyadREl HattabMBenahmedMKeskinMAkkalS. The cosmetic potential of the medicinal halophyte Tamarix gallica L.(Tamaricaceae) growing in the eastern part of Algeria: photoprotective and antioxidant activities.Comb Chem High Throughput Screen2021;24(10):1671–8
54.
SalesPMSouzaPMSimeoniLASilveiraD.α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.J Pharm Pharm Sci2012;15(1):141–83
55.
TanYChangSKZhangY.Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera.Food Chem2017;214:259–68
56.
MalikMSharifAHassanSUMuhammadFKhanHMAkhtarBSaeedM.Amelioration of hyperglycaemia and modulation of pro-inflammatory cytokines by Tamarix gallica fractions in alloxan induced diabetic rats.Arch Physiol Biochem2022;128:1666–75
57.
HmideneBSmaouiAAbdellyCIsodaHShigemoriH.Effect of O-methylated and glucuronosylated flavonoids from Tamarix gallica on α-glucosidase inhibitory activity: structure-activity relationship and synergistic potential.Biosci Biotechnol Biochem2016;81:445–8
58.
MustafaIAnwarHIrfanSMuzaffarHIjazMU.Attenuation of carbohydrate metabolism and lipid profile by methanolic extract of Euphorbia helioscopia and improvement of beta cell function in a type 2 diabetic rat model.BMC Complement Med Ther2022;22:23
