Our fundamental understanding of cell biology and early diagnosis of human diseases have been greatly benefited from the development of fluorescent probes. Over the past decade, luminescent gold nanoparticles (AuNPs) with diverse structural parameters including particle size, surface ligands, valence state and grain size have been synthesized and have begun to emerge as a new class of fluorescent probes for bioimaging because of their great biocompatibility, robust photophysical properties and tunable emissions from the visible range to the near infrared region. In this minireview, we summarize the recent progress in applications of different-sized luminescent AuNPs as imaging probes for both in vitro and in vivo levels.
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