Gas gangrene due to clostridia infections is commonly seen in war injuries and is much less commonly seen in civilian life. When such problems do occur, they present a challenge to the surgeon due to the associated high morbidity and mortality associated. A case is presented where a patient developed gas gangrene in a limb consequent to trauma that had been treated surgically. It is vital to make a correct diagnosis at the earliest to limit disease progression and to avoid complications.
Stevens DLThe pathogenesis of clostridial myonecrosis: Int J Med Microbiol2000;290(4-5):497-502.
2.
Gorbach SLAgs gangrene. In: Gorbach SL, Bartlett JG, Blacklow NR , editors. Infectious disease. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 830.
3.
Darke SG, King AM, Slack WKGas gangrene and related infection: classification, clinical features and aetiology, management and mortality. A report of 88 cases. Br J Surg1977; 64:104-12.
Stevens DL, Bryant AEThe role of clostridial toxins in the pathogenesis of gas gangrene. Clin Infect Dis2002;35(Suppl 1):S93-100.
10.
Awad MM, Ellemor DM, Boyd RL, Emmins JJ, Rood JLSynergistic effects of alpha toxin and perfringolysin O in Clostridium perfringens mediated gas gangrene. Infect Immune2001;69(12):7904-10.
11.
Stevens DL, Tweten RK, Awad MM, Rood JL, Bryant AEClostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis1997;176(1):189-95.
12.
Cabrera A., Tsukada Y., Pickren JWClostridial gas gangrene and septicaemia in malignant disease. Cancer1965;18:800-6.
13.
Jones LE, Wirth WA, Farrow CCClostridial gas gangrene and septicaemia complicating leukaemia. South Med J1960; 53;863-6.
14.
Graham BS, Johnson AC, Sawyers JLClostridial infections of renal cell carcinoma. J Urol1986;135(2):354-5.
15.
Kahn O.The incidence and significance of gas gangrene in a diabetic populationAngiology1974;25(7):462-6.
16.
Nordkild P. , Crone P.Spontaneous clostridial myonecrosis: a collective review and report of a case. Ann Chir Gynaecol1986;75(5):274-9.
17.
Brazier JS, Levett PN, Stannard AJ, Phillips KD, Willis ATAntibiotic susceptibility of clinical isolates of clostridia. J Antimicrob Chemother1985;15(2):181-5.
18.
Altemeier WA , Fullen WDPrevention and treatment of gas gangrene. JAMA1971;217(6):806-13.
19.
Korhonen K. , Klossner J., Hirn M., Niinikoski J.Management of clostridial gas gangrene and the role of hyperbaric oxygen. Ann Chir Gynaecol1999;88(2):139-42.
