This special issue of Clinical Case Studies focuses on recent developments in the psychotherapy of schizophrenia. Approaches such as these are needed to address the multiple rate-limiting factors for psychotherapy outcome in this population, such as poor insight, comorbid disorders, low motivation, cognitive impairments, and self and interpersonal disturbances. In this introductory article, each of the case studies is briefly reviewed, with the goals of: (a) noting how each therapeutic approach fills a gap in current practice, and (b) placing the focus of treatment within a larger context of relevant research on schizophrenia. Concluding comments note the implications of these multiple therapeutic developments for future psychological treatment of schizophrenia.
Bachmann, S., Resch, F., & Mundt, C. ( 2003). Psychological treatments for psychosis: History and overview . Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry, 31, 155-176.
2.
Carr, V., & Wale, J. ( 1986). Schizophrenia: An information processing model. Australian and New Zealand Journal of Psychiatry, 20, 136-155.
3.
Chadwick, P. ( 2006). Person-based cognitive therapy for distressing psychosis . Hoboken, NJ: Wiley.
4.
Chadwick, P., Birchwood, M.J., & Trower, P. ( 1999). Cognitive therapy for delusions, voices and paranoia . Hoboken, NJ: Wiley.
5.
Chapman, J. ( 1966). The early symptoms of schizophrenia. British Journal of Medical Psychology, 112, 225-251.
6.
Conrad, K. ( 1958). Die beginnende schizophrenie. Versuch einer gestaltanalyse des wahns (3rd ed.) [The early phase of schizophrenia: An attempt at a Gestalt analysis of madness (3rd ed.)]. Stuttgart: Thieme.
7.
Danion, J.M., Rizzo, L., & Bruant, A. ( 1999). Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Archives of General Psychiatry, 56, 639-644.
8.
David, A.S. ( 2004). The clinical importance of insight: An overview. In X. F. Amador & A. S. David (Eds.), Insight and psychosis: Awareness of illness in schizophrenia and related disorders (pp. 359-392). Oxford, UK: Oxford University Press.
9.
Dimaggio, A., Semerari, A., Carcione, A., Nicolò, G., & Procacci, M. ( 2007). The perpetuation of personality disorders: A model. In G. Dimaggio, A. Semerari, A. Carcione, G. Nicolò, & M. Procacci (Eds.), Psychotherapy of personality disorders. Metacognition, states of mind and interpersonal cycles (pp. 1-29). London : Routledge.
10.
Freeman, D., Garety, P.A., Fowler, D., Kuipers, E., Bebbington, P.E., & Dunn, G. ( 2004). Why do people with delusions fail to choose more realistic explanations for their experiences? An empirical investigation. Journal of Consulting and Clinical Psychology, 72, 671-680.
11.
Garety, P.A., Fowler, D., Kuipers, E., Freeman, D., Dunn, G., Bebbington, P., et al. (1997). London-East Anglia randomized controlled trial of cognitive-behavioural therapy for psychosis. II. Predictors of outcome. British Journal of Psychiatry, 171, 420-426.
12.
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., et al. (2004). Modulation of corticallimbic pathways in major depression: Treatment-specific effects of cognitive behavior therapy . Archives of General Psychiatry, 61, 34-41.
13.
Gottdiener, W.H., & Haslam, N. ( 2003). A critique of the methods and conclusions in the patient outcome research team (PORT) report on psychological treatments for schizophrenia . Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry, 31, 191-208.
14.
Green, M.F., Penn, D.L., Bentall, R., Carpenter, W.T., Gaebel, W., Gur, R.C., et al. (2008). Social cognition in schizophrenia: An NIMH workshop on definitions, assessment, and research opportunities. Schizophrenia Bulletin, 34, 1211-1220.
15.
Gunderson, J.G., Frank, A.F., Katz, H.M., Vannicelli, M.L., Frosch, J.P., & Knapp, P.H. ( 1984). Effects of psychotherapy in schizophrenia: II. Comparative outcome of two forms of treatment. Schizophrenia Bulletin , 10, 564-598.
16.
Hogarty, G.E., Kornblith, S.J., Greenwald, D., DiBarry, A.L., Cooley, S., Flesher, S., et al. (1995). Personal therapy: A disorder-relevant psychotherapy for schizophrenia. Schizophrenia Bulletin, 21, 379-393.
17.
Kingdon, D. (In press). Over-simplification and exclusion of non-conforming studies can demonstrate absence of effect: A lynching party?Psychological Medicine.
18.
Knight, R.A. ( 1984). Converging models of cognitive deficit in schizophrenia . In W. D. Spaulding & J. K. Cole (Eds.), Nebraska symposium on motivation, 1983: Theories of schizophrenia and psychosis (pp. 93-156). Lincoln, NE: University of Nebraska Press.
19.
Knight, R.A., & Silverstein, S.M. (1998). The role of cognitive psychology in guiding research on cognitive deficits in schizophrenia. In M. Lenzenweger & R.H. Dworkin (Eds.), Origins and development of schizophrenia: Advances in experimental psychopathology (pp. 247-295). Washington, DC: APA.
20.
Leavitt, V.M., & Goldberg, T.E. (In press). Episodic memory in schizophrenia . Neuropsychology Review.
21.
Liberman, R.P., Kopelowicz, A., & Silverstein, S.M. (2005). Psychiatric rehabilitation . In B. J. Sadock & V. A. Sadock (Eds.), Kaplan & Sadock’s comprehensive textbook of psychiatry (8th ed., pp. 3884-3930). New York: Lippincott Williams & Wilkins.
22.
Lynch, D., Laws, K.R., & McKenna, P.J. ( 2009). Cognitive behavioural therapy for major psychiatric disorder: Does it really work? A meta-analytical review of well-controlled trials. Psychological Medicine, 29, 1-16.
23.
Lysaker, P.H., Buck, K.D., & Hammoud, K. ( 2007). Psychotherapy and schizophrenia: An analysis of requirements of individual psychotherapy with persons who experience manifestly barren or empty selves. Psychology and Psychotherapy30, 377-387.
24.
Lysaker, P.H., Buck, K.D., & Roe, D. ( 2007). Psychotherapy and recovery in schizophrenia: A proposal of critical elements for an integrative psychotherapy attuned to narrative in schizophrenia. Psychological Services, 4, 28-37.
25.
Lysaker, P.H., Carcione, A., Dimaggio, G., Johannesen, J.K., Nicolò, G., Procacci, M., et al. (2005). Metacognition amidst narratives of self and illness in schizophrenia: Associations with insight, neurocognition, symptom and function. Acta Psychiatrica Scandinavica, 112, 64-71
26.
Lysaker, P.H., Davis, L.W., Jones, A.M., Strasburger, A.M., & Hunter, N.L. ( 2007). The interplay of relationship and technique in the long-term psychotherapy of schizophrenia: A single case study. Counselling and Psychotherapy Research, 7, 79-85.
27.
Lysaker, P.H., Glynn, S., Wilkniss, S., & Silverstein, S.M. (In press). Psychotherapy and recovery from severe mental illness: A review of potential application and need for future study. Psychological Services.
28.
Matussek, P. ( 1987). Studies in delusional perception. Translated and condensed in J. Cutting & M. Sheppard (Eds.), Clinical roots of the schizophrenia concept. Translations of seminal European contributions on schizophrenia (pp. 87-103). Cambridge, UK: Cambridge University Press. (Original work published in 1952).
29.
McGhie, A., & Chapman, J. ( 1961). Disorders of attention and perception in early schizophrenia . British Journal of Medical Psychology, 34, 103-115.
30.
McGowan, P.O., & Kato, T. ( 2008). Epigenetics in mood disorders. Environmental Health and Preventitive Medicine, 13, 16-24.
31.
McGowan, P.O., Sasaki, A., D’Alessio, A.C., Dymov, S., Labonté, B., Szyf, M. et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342-348.
32.
Mueser, K.T., Rosenberg, S.D., Xie, H., Jankowski, M.K., Bolton, E.E., Lu, W., et al. (2008). A randomized controlled trial of cognitive-behavioral treatment for posttraumatic stress disorder in severe mental illness. Journal of Consulting and Clinical Psychology, 76, 259-271.
33.
Perivoliotis, D., & Cather, C. ( 2009). Cognitive behavioral therapy of negative symptoms. Journal of Clinical Psychology, 65, 815-830.
34.
Phillips, W.A., & Silverstein, S.M. (2003). Impaired cognitive coordination in schizophrenia: Convergence of neurobiological and psychological perspectives . Behavioral and Brain Sciences, 26, 65-82.
35.
Read, J., van Os, J., Morrison, A.P., & Ross, C.A. ( 2005). Childhood trauma, psychosis and schizophrenia: A literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica, 112, 330-350.
36.
Sass, L. ( 1992). Madness and modernism. Insanity in the light of modern art, literature, and thought. Cambridge, MA: Harvard University Press.
37.
Sass, L.A., Parnas, J. ( 2003). Schizophrenia, consciousness, and the self. Schizophrenia Bulletin, 29, 427-444.
38.
Semerari, A., Carcione, A., Dimaggio, G., Falcone, M., Nicolo, G., Procaci, M., et al. (2003). How to evaluate metacognitive function in psychotherapy? The Metacognition Assessment Scale and its applications . Clinical Psychology and Psychotherapy, 10, 238-261.
39.
Shemberg, K.M., & Leventhal, D.B. (1972). Outpatient treatment of schizophrenic students in a university clinic. Bulletin of the Menninger Clinic, 36, 617-640.
40.
Silverstein, S.M. ( 2007). Integrating Jungian and self-psychological perspectives within cognitive-behavior therapy for a young man with a fixed religious delusion . Clinical Case Studies, 6, 263-276.
41.
Silverstein, S.M., & Bellack, A. ( 2008). A scientific agenda for the concept of recovery as it applies to schizophrenia. Clinical Psychology Review, 28, 1108-1124.
42.
Silverstein, S.M., & Schenkel, L. ( 1997). Schizophrenia as a model of context-deficient cortical computation. Behavioral and Brain Sciences, 20, 696-697.
43.
Spence, W., Mulholland, C., Lynch, G., McHugh, S., Dempster, M., & Shannon, C. ( 2006). Rates of childhood trauma in a sample of patients with schizophrenia as compared with a sample of patients with non-psychotic psychiatric diagnoses. Journal of Trauma and Dissociation, 7, 7-22.
44.
Szyf, M., McGowan, P., & Meaney, M.J. ( 2008). The social environment and the epigenome. Environmental and Molecular Mutagenesis, 49, 46-60.
45.
Uhlhaas, P.J., & Silverstein, S.M. (2005). Perceptual organization in schizophrenia spectrum disorders: A review of empirical research and associated theories. Psychological Bulletin, 131, 618-632.
46.
van Winkel, R., Stefanis, N.C., & Myin-Germeys, I. (2008). Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophrenia Bulletin, 34, 1095-1105.
47.
Wichers, M., Schrijvers, D., Geschwind, N., Jacobs, N., Myin-Germeys, I., Thiery, E., et al. (2009). Mechanisms of gene-environment interactions in depression: Evidence that genes potentiate multiple sources of adversity. Psychological Medicine, 39, 1077-1086.
48.
Wykes, T., Steel, C., Everitt, B., & Tarrier, N. ( 2008). Cognitive behavior therapy for schizophrenia: Effect sizes, clinical models, and methodological rigor. Schizophrenia Bulletin, 34, 523-537.
