This article reports the effects of language-enriched physical fitness interventions provided by University of Arizona undergraduate students to 24 mild-to moderate-stage Alzheimer’s disease patients (AD Rehab group). Socialization experiences consisted of supervised volunteer work and cultural/recreational activities. Changes in global functioning and neuropsychological test performance were tracked and compared to those of a similar group of untreated patients from the Consortium for the Establishment of a Registry for Alzheimer’s Disease (CERAD). Cohorts completing 4 semesters or longer showed no significant between-year changes after their first year on the Clinical Dementia Rating, a measure of global functioning, and on 5 or 6 of the cognitive and language measures. Comparisons with the CERAD sample suggested a slower rate of decline for the AD Rehab group. The stabilization of global and cognitive performance was not apparent among participants who completed only 2 semesters. Significant physical fitness and mood outcomes were previously reported in this journal.
McKhann G, Albert M.Keep Your Brain Young. New York, NY: John Wiley; 2002.
2.
Evans W, Rosenberg IH.Biomarkers: The Ten Determinants of Aging You Can Control. New York, NY: Simon & Schuster; 1991.
3.
Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. (2001). Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of Neurology.2001; 58: 498-504
4.
Friedland RP, Smyth KA, Rowland DY.Pre-morbid activities are reduced in patients with Alzheimer’s disease as compared to age- and sex-matched controls: results of a case-control study. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, eds. Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. New York, NY: John Wiley; 1997.
5.
Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky KR.A prospective study of physical activity and cognitive decline in elderly women who walk. Arch Intern Med. 2001; 161: 1703-1708.
6.
Weuve J, Kang JH, Manson JE, Breteler MMB, Ware JH, Grodstein F.Physical activity, including walking, and cognitive function in older women. JAMA. 2004;292: 1454-1461.
7.
Abbott RD, White LR, Ross W, Masaki KH, Curb JD, Petrovitch H.Walking and dementia in physically capable elderly men. JAMA. 2004;292: 1447-1453.
8.
Teri L, Gibbons LE, McCurry SM, et al.Exercise plus behavioral management in patients with Alzheimer’s disease: a randomized controlled trial. JAMA. 2003;290: 2015-2022.
9.
van Praag H, Kemperman G, Gage FH.Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999;2: 266-270.
10.
Cotman C, Engesser-Cesar C.Exercise enhances and protects brain function. Exerc Sport Sci. 2002;30: 75-79.
11.
Vermeer SE, den Heijer T, Prins ND, Hofman A, Koudstaal PJ, Breteler MMB. Silent brain infarcts and the risk of dementia and cognitive decline: the Rotterdam Scan Study. N Engl J Med. 2003;348: 1215-1222.
12.
Adlard PA, Perreau VM, Cotman CW.Exercise-induced expression of BDNF within the hippocampus. Neurobiol Aging. 2005;26: 522-520.
13.
Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics K, Sisodia SS.Environmental enrichment reduces A-beta levels and amyloid deposition in transgenic mice. Cell. 1999;120: 701-725.
14.
Wilson RS, Bennett DA, Bienias JL, et al.Cognitive activity and incident AD in a population-based sample of older persons. Neurology. 2002;59: 1910-1914.
15.
Verghese J, Lipton RB, Katz MJ, et al.Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003;348: 2508-2516.
16.
Podewils LJ, Guallar E, Kuller LH, et al.Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161: 639-651.
17.
Milgram NW, Head E, Zicker S, et al.Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging. 2005;26: 77-90.
18.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM.Clinical diagnosis of Alzheimer’s disease. Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34: 939-944.
19.
Folstein MF, Folstein SE, McHugh PR.“Mini-Mental State,” a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12: 189-198.
Morris JC:Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1994;43: 2412-2414.
22.
Yesavage J, Brink T, Rose T, et al.Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1983;17: 37-49.
23.
Wechsler D.Wechsler Memory Scale-Revised. New York, NY: Psychological Corporation; 1987.
24.
Bayles KA, Tomoeda C.Arizona Battery for Communication Disorders of Dementia (ABCD). Tucson, Ariz: Canyonlands; 1991.
25.
Arkin S, Mahendra N.Discourse analysis of Alzheimer’s patients before and after intervention: methodology and outcomes. Aphasiology. 2001;15: 533-569.
26.
Mahendra N, Arkin S.Effects of four years of exercise, language, and social interventions on Alzheimer discourse. J Commun Disord. 2003;36: 395-422.
27.
Tappen RM, Roach KE, Buchner D, Barry C, Edelstein J.Reliability of physical performance measures in nursing home residents with Alzheimer’s disease. J Geront Med Sci. 1997;52A: M52-M55.
28.
Arkin S.Student-led exercise sessions yield significant fitness gains for Alzheimer’s patients. Am J Alzheimers Dis. 2003;18: 159-170.
29.
Orange JB, Purves B.Conversational discourse and cognitive impairment: implications for Alzheimer’s disease. J Speech-Lang Pathol Audiol. 1996;20: 139-150.
30.
Arkin S.Audio-assisted memory training with early Alzheimer patients: two single subject experiments. Clin Gerontol. 1992;12: 77-96.
31.
Arkin S.Alzheimer memory training: students replicate learning successes. Am J Alzheimers Dis. 2000;15: 152-162.
32.
Arkin S.Alzheimer memory training: addendum on long-term retention. Am J Alzheimers Dis. 2000;15: 314-315.
33.
Arkin S, Smith M.Language-enriched exercise for clients with Alzheimer’s disease. Correspondence continuing education course. Tucson, Ariz: Desert Southwest Fitness. Available at: www.DSWFitness.com.
Keys LM.Former patients as volunteers in community agencies: a model work program. Hosp Community Psychiatry. 1982;33: 1017-1018.
36.
Griffin R, Mouheb F.Work therapy as a treatment modality for the elderly patient with dementia. Phys Occup Ther Geriatr. 1987;5: 13-27.
37.
Hughes M.Enhancing the Self-esteem of the Nursing Home Resident. LaGrange, Tex: M and H Publishing; 1991.
38.
Mace NL.Principles of activities for persons with dementia. Phys Occup Ther Geriatr. 1987;5: 13-27.
39.
Stansell J.Volunteerism: contributions by people with dementia. In: Harris PB, ed. The Person With Alzheimer’s Disease: Understanding the Experience. Baltimore, Md: Johns Hopkins University Press; 2002.
Heyman A, Fillenbaum GG:CERAD overview: clinical sites, case material, and special studies. Neurology. 1997;49(suppl 3): S2-S6.
42.
Heyn P, Abreu BC, Ottenbacher KJ.The effects of exercise training on dementia: a meta-analysis. Arch Phys Med Rehabil. 2004;85:: 1694-1704.
43.
Fratiglioni L, Wang HX, Maytan M, Winblad B.Influence of social networks on occurrence of dementia: a community-based longitudinal study. Lancet. 2000; 355: 1315-1319.
44.
Alzheimer’s Association. African-Americans and Alzheimer’s disease: the silent epidemic. Special report, 2002. Available at: www.alz.org/Resources/Diversity/BlackAfricanAmerican.asp.
45.
Barnett E, Casper ML, Halverson, JA, et al.Men and Heart Disease: An Atlas in Racial and Ethnic Disparities in Mortality. Morgantown: Office for Social Environment and Health Research, West Virginia University; 2001.
46.
Carter JS, Pugh JA, Monterrosa A.Non-insulin dependent diabetes mellitus in the United States. Ann Intern Med. 1996;125: 237-239.
47.
Arkin S, Mahendra N.Insight in Alzheimer’s patients: results of a longitudinal study using three assessment methods. Am J Alzheimers Dis. 2001;16: 211-224.
