Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and association auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, Rsize, and Roverlap. The average difference in the COM, Rsize, and Roverlap values ranged from 1.70 ± 0.53 mm −10.60 ± 3.21 mm, 0.6 ± 0.04–0.90 ± 0.05 and 0.23 ± 0.12 −1 ± 0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.
JackC. R.ThompsonR. M.ButtsR. K.SharbroughF. W.KellyP. J.HansonD. P.RiedererS. J.EhmanR. L.HangiandreouN. J.CascinoG. D.Sensory motor cortex: Correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology190, 85–92 (1994).
5.
FitzGerladD. B.CosgroveG. R.RonnerS.JingH.BuchbinderB. R.BelliveauJ. W.RosenB. R.BensonR. R.Location of language in the cortex: A comparison between functional MR imaging and electrocortical stimulation. AJNR Am J Neuroradiol18, 1529–1539 (1997).
6.
PouratianN.BookheimerS. Y.RexD. E.MartinN. A.TogaA. W.Utility of preoperative functional magnetic resonance imaging for identifying language cortices in patients with vascular malformations. Neurosurg Focus13, 21–32 (2002).
7.
DisbrowE. A.SlutskyD. A.RobertsT. P.KrubitzerL. A.Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level-dependent signal and electrophysiology. Proc Natl Acad Sci USA97, 9718–9723 (2000).
8.
LiuW.SchulderM.NarraV.KalninA. J.CathcartC.JacobsA.LangeG.HolodnyA. I.Functional magnetic resonance imaging aided radiation treatment planning. Med Phys27, 1563–1572 (2000).
9.
AtlasS. W.HowardR. S.MaldjianJ.AlsopD.DetreJ. A.ListerudJ.D'EspositoM.JudyK.ZagerE.SteckerM.Functional magnetic resonance imaging of regional brain activity in patients with intracerebral gliomas: Findings and implications for clinical management. Neurosurgery38, 329–338 (1996).
10.
RoessierK.DonatM.LanzenbergerR.NovakK.GeisslerA.GartusA.TahamtanA. R.MilakaraD.CzechT.BarthM.KnospE.BeisteinerR.Evaluation of preoperative high magnetic field motor functional MRI (3 tesla) in glioma patients by navigated electrocortical stimulation and postoperative outcome. J Neurol Neurosurg Psychiatry76, 1152–1157 (2005).
11.
SuessO.SuessS.BrockM.KombosT.Intraoperative electrocortical stimulation of Brodman area 4; a 10-year analysis of 255 cases. Head & Face Medicine2, 1–13 (2006).
12.
BookheimerS.Pre-surgical language mapping with functional magnetic resonance imaging. Neuropshychology Review17, 145–155 (2007).
13.
FitzGerladD. B.CosgroveG. R.RonnerS.JingH.BuchbinderB. R.BelliveauJ. W.RosenB. R.BensonR. R.Location of language in the cortex: A comparison between functional MR imaging and electrocortical stimulation. AJNR Am J Neuroradiol18, 1529–1539 (1997).
14.
CaseyB. J.CohenJ. D.O'CravenK.DavidsonR. J.IrwinW.NelsonC. A.NollD. C.HuX.LoweM. J.RosenB. R.TruwittC. L.TurskiP. A.Reproducibility of fMRI results across four institutions using a spatial working memory task. Neuroimage8, 249–261 (1998).
15.
MaldjianJ. A.LaurientiP. J.DriskillL.BurdetteJ. H.Multiple reproducibility indices for evaluation of cognitive functional MR imaging paradigms. AJNR Am J Neuroradiol23, 1030–1037 (2002).
16.
HarringtonG. S.BuonocoreM. H.FariasS. T.Intrasubject reproducibility of functional MR imaging activation in language tasks. AJNR Am J Neuroradiol27, 938–44 (2006).
17.
HavelP.BraunB.RauS.TonnJ. C.FeslG.CruckmannH.IlmbergerJ.Reproducibility of activation in four motor paradigms: An fMRI study. J Neurol253, 471–6 (2006).
18.
VliegerE. J.LaviniC.MajoieC. B.HeetenG. J.Reproducibility of functional MR imaging results using two different MR systems. AJNR Am J Neuroradiol24, 652–657 (2003).
19.
RomboutsS. A. R. B.BarkhofF.HoogeneraadF. G. C.SprengerM.ValkJ.ScheltensP.Test-retest analysis with functional MR of the activated area in the human visual cortex. AJNR18, 1317–1322 (1997).
20.
RomboutsS. A. R. B.BarhofF.HoogenraadF. G. C.SprengerM.ScheltensP.Within-subject reproducibility of visual activation patterns with functional magnetic resonance imaging using multislice echo planar imaging. MRI16, 105–113 (1998).
21.
CoxR. W.AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res29, 162–173 (1996).
22.
RuffI. M.PetrovichBrennanN. M.PeckK. K.HouB. L.TabarV.BrennanC. W.HolodnyA. I.Assessment of the language laterality index in patients with brain tumor using functional MR imaging: Effects of thresholding, task selection, and prior surgery. AJNR29, 528–535 (2008).
