The salient properties of laser light and the way light interacts with biological tissues and molecular constituents of tissues offer possibilities for detection and diagnosis of cancer. In particular, the wavelength selectivity of tunable lasers, narrow bandwidth around the selected wavelength, and spectral brightness enable probing of key molecular constituents of tissues, and endow laser-based techniques with much desired diagnostic potential. This article presents an overview of some recent developments in optical imaging and optical biopsy of different types of cancers, and illustrates the diagnostic role of the color of light.
GayenS. K. and AlfanoR. R.Emerging Optical Biomedical Imaging Techniques. Opt. Phot. News7, 17 (1996).
2.
DolmansD. E. J. G. J., FukumaraD., JainR. K.Photodynamic Therapy for Cancer. Nature Reviews Cancer3, 380–387 (2003).
3.
VrouenraetsM. B., VisserV. W. M., SnowG. B., van DongenG. A. M. S.Basic Principles, Applications in Oncology and Improved Selectivity of Photodynamic Therapy. Anticancer Research23, 505–522 (2003).
AlfanoR. R., GayenS. K., and KatzA.Advances in Mediphotonic Imaging and Biopsy. In Optics and Imaging in the Information Age, pp.299–305. IS&T-The Society for Imaging Science and Technology, Springfield, VA (1997).
6.
SvanbergS.Atomic and Molecular Spectroscopy, pp. 342. Springer Verlag, Berlin, (1991).
7.
SivaramakrishnaR.Foreword: Imaging Techniques Alternative to Mammography for Early Detection of Breast Cancer. Technology in Cancer Research4, 1–3 (2005).
8.
TindallD. J. and ScardinoP. T.Defeating Prostate Cancer: Crucial Directions for Research-Excerpt from the Report of the Prostate Cancer Progress Review Group (Review). Prostate38, 166–171 (1999).
9.
YooK. M. and AlfanoR. R.Time-resolved Coherent and Incoherent Components of Forward Light Scattering in Random Media. Opt. Lett.15, 320–322 (1990).
10.
WangL., HoP. P., LiuC., ZhangG., and AlfanoR. R.Ballistic 2-D Imaging Through Scattering Wall using an Ultrafast Kerr Gate. Science253, 769–771 (1991).
11.
PattersonM. S., ChanceB., and WilsonB. C.Time-resolved Reflectance and Transmittance for the Noninvasive Measurement of Tissue Optical Properties. Appl. Opt.28, 2331–2336 (1989).
12.
DolneJ. J., YooK. M., LiuF., and AlfanoR. R.IR Fourier Space Gate and Absorption Imaging Through Random Media. Lasers in Life Sciences6, 131–141 (1994).
13.
ChanK. P., YamadaM., and InabaH.Optical Imaging Through Highly Scattering Media by Use of Heterodyne Detection in the 1.3-μm Wavelength Region. Opt. Lett.20, 492–494 (1995).
14.
HeeM. R., IzzatJ., JacobsonJ., FujimotoJ. G., and SwansonE. A.Femtosecond Transillumination Optical Coherence Tomography. Opt. Lett.18, 950–952 (1993).
15.
DemosS. G. and AlfanoR. R.Temporal Gating in Highly Scattering Media by the Degree of Optical Polarization. Opt. Lett.21, 161–163 (1996).
16.
YooK. M., LiuF., and AlfanoR. R.Imaging Through a Scattering Wall Using Absorption. Opt. Lett.16, 1068–1070 (1991).
17.
O'LearyM. A., BoasD. A., ChanceB., and YodhA. G.Experimental Images of Heterogeneous Turbid Media by Frequency-domain Diffusing-photon Tomography. Opt. Lett.20, 426–428 (1995).
18.
SappeyA. D.Optical Imaging Through Turbid Media with a Degenerate Four Wave Mixing Correlation Time Gate. Appl. Opt.30, 1796–1803 (1991) and relevant references therein.
19.
HebdenJ. C., ArridgeS. R., and DeplyD. T.Optical Imaging in Medicine: I. Experimental Techniques. Phys. Med. Biol.42, 825–840 (1997).
20.
CutlerM.Transillumination as an Aid in the Diagnosis of Breast Lesion. Surg. Gynecol. Obstet.48, 721–730 (1929).
21.
GayenS. K. and AlfanoR. R.Sensing Lesions in Tissues with Light. Opt. Express4, 475–480 (1999).
22.
GayenS. K., AlrubaieeM., ZevallosM., and AlfanoR. R.Spectrally and Temporally Resolved Optical Imaging of Normal and Cancerous Human Breast Tissues. Proceedings of the Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, pp. 142–147. Ed., GandjbakhcheAmir H.. Optical Society of America, Washington DC (2000).
23.
BrezinskiM. E. and FujimotoJ. G.Optical Coherence Tomography: High-resolution Images in Nontransparent Tissue. IEEE J. Select Topics Quantum Electron.5, 1185–1192 (1999), and relevant references therein.
24.
PitrisC., GoodmanA. K., BoppartS. A., LibusJ. J., FujimotoJ. G., and BrezinskiM. E.High Resolution Images of Cervical and Uterine Malignancies Using Optical Coherence Tomography. Obstect. and Gyn.93, 135–139 (1999).
25.
ArridgeS. R. and HebdenJ. C.Optical Imaging in Medicine: II. Modeling and Reconstruction. Phys. Med. Biol.42, 841–853 (1997).
26.
ArridgeS. R.Optical Tomography in Medical Imaging. Inverse Probl.15, R41–R93 (1999).
27.
CaiW., DasB. B., LiuF., ZevallosM., LaxM., and AlfanoR. R.Time-resolved Optical Diffusion Tomographic Image Reconstruction in Highly Scattering Turbid Media. Proc. Natl. Acad. Sci. USA93, 13561–13563 (1996).
28.
CaiW., GayenS. K., XuM., ZevallosM., AlrubaieeM., LaxM., and AlfanoR. R.Optical Tomographic Image Reconstruction From Ultrafast Time-sliced Transmission Measurements. Appl. Opt.38, 4237–4246 (1999).
29.
MarkelV. A. and SchotlandJ. C.Scanning Paraxial Optical Tomography. Opt. Lett.27, 1123–1125 (2002).
30.
GandjbakhcheA. H., ChernomordikV., HebdenJ. C., and NossalR.. Time-dependent Contrast Functions for Quantitative Imaging in Time-resolved Transillumination Experiments. Appl. Opt.37, 1973–1981 (1998).
31.
NtziachristosV., YodhA., SchnallM., and ChanceB.MRI-guided Diffuse Optical Spectroscopy of Malignant and Benign Breast Lesions. Neoplasia4, 347–354 (2002).
32.
GrosenickD., MoestaK. T., WabnitzH., MuckeJ., StroszczynskiC., MacdonaldR., SchlagP. M., and RinnebergH.Time-domain Optical Mammography: Initial Clinical Results on Detection and Characterization of Breast Tumors. Appl. Opt.42, 3170–3186, (2003).
33.
DehganiH., PougeB. W., PoplackS. P., and PaulsenK. D.Multiwavelength Three-dimensional Near-infrared Tomography of the Breast: Initial Simulation, Phantom, and Clinical Results. Appl. Opt.42, 135–145 (2003).
34.
ColakS. B., van der MarkM. B., 't HooftG. W., HoogenraadJ. H., van der LindenE. S., and KuijpersF. A.Clinical Optical Tomography and NIR Spectroscopy for Breast Cancer Detection. IEEE J. Select. Topics Quantum Electron.5, 1143–1158 (1999).
35.
TaroniP., DanesiniG., TorricelliA., PifferiA., SpinelliL., CubedduR.Clinical Trial of Time-resolved Scanning Optical Mammography at 4 Wavelengths Between 683 and 975 nm. J. Biomed. Opt.9, 464–473 (2004).
36.
FranceschiniM. A., MoestaK. T., FantiniS., GaidaG., GrattonE., JessH., MantulinW. W., SeeberM., SchlagP. M., and KaschkeM.Frequency-domain Techniques Enhance Optical Mammography: Initial Clinical Results. Proc. Natl. Acad. Sci. USA94, 6468–6473 (1997).
37.
SchmitzC. H., KlemerD. P., HardinR. E., KatzM. S., PeiY., GraberH. L., LevinM. B., LevinaR. D., FrancoN. A., SolomonW. B., and BarbourR. L.Design and Implementation of Dynaic Near-infrared Optical Tomographic Imaging Instrumrntation for Simultaneous Dual-breast Measurements. Appl. Opt.44, 2140–2153 (2005).
38.
ChengX., MaoJ. M., BushR., KopansD. B., MooreR. H., and ChorltonM.Breast Cancer Detection by Mapping Hemoglobin Concentration and Oxygen Saturation. Appl. Opt.42, 6412–6421 (2003).
39.
ShahN., CerussiA. E., JakubowskiD., HsiangD., ButlerJ., and TrombergB. J.The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer. Disease Markers19, 95–105 (2004).
40.
YooK. M., LiuFeng, and AlfanoR. R.When Does the Diffusion Approximation Fail to Describe Photon Transport in Random Media? Phys. Rev. Lett.64, 2647–2749 (1990).
41.
ViatorJ. A., KarabutovA. A., and OraevskyA. A.Sensitivity of Laser Opto-acoustic Imaging in Detection of Small Deeply Embedded Tumors. IEEE J. Select Topics Quantum Electron.5, 989–996 (1999).
42.
WangL.-H.Ultrasound-mediated Biophotonic Imaging: A Review of Acousto-optical Tomography and Photo-acoustic Tomography. J. Disease Markers19, 123–138 (2004).
43.
AlrubaieeM., GayenS. K., KoutcherJ. A., and AlfanoR. R.Cancerous and Normal Human Tissues Investigated by Near-infrared Time-resolved and Spectroscopic Imaging Techniques. SPIE 4955, 199 (2003).
44.
GayenS. K., ZevallosM. E., and AlfanoR. R.Near-infrared Laser Spectroscopic Imaging: A Step Towards Diagnostic Optical Imaging of Human Tissues. Lasers in the Life Sciences8, 187 (1999).
45.
MarksF. A.Optical Determination of the Hemoglobin Oxygenation State of Breast Biopsies and Human Breast Cancer Xenografts in Nude Mice. In Proc. Physiological Monitoring and Early Detection Diagnostic Methods, pp. 227–237. Eds., MangT. S. and KatzirA.. Belingham, WA (1992).
46.
CerussiA. E., JakubowskiD., ShahN., BeviacquaF., LanningR., BergerA. J., HsiangD., ButlerJ., and TrombergB. J.Spectroscopy Enhances the Information Content of Optical Mammography. J. Biomed. Opt.7, 60–71 (2002).
47.
AliJ. H., WangW. B., ZevallosM., and AlfanoR. R.Near-infrared Spectroscopy and Imaging to Probe Differences in Water Content in Normal and Cancer Human Prostate Tissues. Technology in Cancer Research and Treatment3, 491–497 (2004).
48.
AlfanoR. R. and MastersB. R.Biomedical Optical Biopsy. Classic Reprints on CD-ROM, Volume 2, Optical Society of America (2003).
49.
AlfanoR. R., TataD. B., CorderoJ. J., TomashefskyP., LongoF. W., and AlfanoM. A.Laser Induced Fluorescence Spectroscopy from Native Cancerous and Normal Tissues. IEEE J. Quantum Electron. QE-20, 1507 (1984).
50.
AlfanoR. R., TangG. C., PradhanA., LamW., ChoyD. S. J., and OpherE.Fluorescence Spectra From Cancerous and Normal Human Breast and Lung Tissues. IEEE J. Quantum Electron. QE-23, 1806 (1987).
51.
YangY., CelmerE. J., KoutcherJ. A., AlfanoR. R.DNA and Protein Changes Caused by Disease in Human Breast Tissues Probed by the Kubelka-Munk Spectral Function. Photochem. & Photobiol.75, 627 (2002).
52.
ShomackerK. T., FrisoliJ. K., ComptonC. C., FlotteT. J., RichterJ. M., NishiokaN. S., and DeutschT. F.Ultraviolet Laser Induced Fluorescence of Colonic Tissue: Basic Biology and Diagnostic Potential. Lasers Surg. Med.12, 63 (1992).
53.
AlfanoR. R., DasB. B., ClearyJ., PrudenteR., and CelmerE. J.Light Sheds Light on Cancer: Distinguishing Malignant Tumors from Benign Tissues and Tumors. Bull. NY Acad. Sci.67, 143 (1991).
54.
Sha GlassmanW., LiuC. H., TangG. C., LubiczS., and AlfanoR. R.Ultraviolet Excited Fluorescence Spectra from Non-malignant and Malignant Tissues of the Gynecological Tract. Lasers Life Sci.5, 49 (1992).
55.
CothrenR. M., Richards-KortumR., SivakM. V., FitzmauriceM., RavaR. P., BoyceG. A., DoxtaderM., BlackmanR., IvancT. B., HayesG. B., FeldM. S., and PetrasR. E.. Gastrointestinal Tissue Diagnosis by Laser-induced Fluorescence Spectroscopy at Endoscopy. Gastrointest Endosc.36, 105 (1990).
MichaletX., PinaudF. F., BentolilaL. A., TsayJ. M., DooseS., LiJ. J., SundaresanG., WuA. M., GambhirS. S., and WeissS.Quantum Dots for Live Cells, In Vivo Imaging and Diagnostics. Science307, 538–544 (2005).
58.
AlfanoR. R. and YangY.Stokes Shift Emission Spectroscopy of Human Tissue and Key Biomolecules. IEEE J. Selected Topics Quantum Electron9, 148–153 (2003).
59.
AlfanoR. R. and YangY.Stokes Shift Emission Spectroscopy of key Biomolecules in Human Tissues. Proc. of SPIE5326, 1–7 (2004).
60.
MahadevanA. and Richards-KortumR.Raman Spectroscopy for the Detection of Cancers and Precancers. J. Biomed. Opt.1, 31 (1996), and references therein.
