The field of tissue adhesives has recently developed a number of novel clinical applications especially relevant to the surgical specialties. Fibrin glue has been commonly used as a hemostatic agent. In this article, we discuss the most common use of fibrin glue as an adjunct to control hemorrhage, as well as its use as a means to deliver biologic substances to a target. We then will describe some novel applications of fibrin glue in various specialties. Future applications of biologic tissue adhesives will depend on our ability to develop a product that will provide all the benefits discussed without incurring the potential risk of viral transmission.
Sierra DHFibrin glue adhesive systems: a review of their chemistry, material properties and clinical applications. J Biomater Appl1993;7:309-352
2.
Spangler HP, Braun F., Holle J., Moritz E., Wolner E.Die lokale Anwendung von Fibrinogen und Kollagen zur Blutstillung in der Herzchirurgie . Wein Med Wochenschr1976;126:86-89
3.
Jacob H., Campbell CD, Qiu Z-K., Pick R., Replogle R.Use of fibrin glue in reinforcing arterial anastomoses. J Vasc Surg1984;1:171-180
Milne AA, Murphy WG, Reading SJ, Ruckley CVFibrin glue reduces suture line bleeding during carotid endarterectomy: a randomised trial. Eur J Vasc Endovasc Surg1995;10:91-94
6.
Milne AA, Murphy WG, Reading SJ, Ruckley CVA randomised trial of fibrin glue in peripheral vascular surgery. Vox Sang1996;70:210-212
7.
Jonas RA, Schoen FJ, Ziemer G., Britton L., Castaneda ARBiological sealants and knitted dacron conduits: comparison of collagen and fibrin glue pretreatments in circulatory models. Ann Thorac Surg1987;44:283-290
8.
Glimaker H., Bjorck CG, Hallstensson S., Ohlsen L., Westman B.Avoiding blow-out of the aortic stump by reinforcement with fibrin glue. A report of two cases. Eur J Vasc Surg1993;7:346-348
Ney AL, Kelly PH, Tsukayama DT, Bubrick MPFibrin glue-antibiotic suspension in the prevention of prosthetic graft infection . J Trauma1990;30:1000-1005
11.
Herring M., Gardner A., Glover J.A single-staged technique for seeding vascular grafts with autogenous endothelium . Surgery1978;84:498
12.
Kaehler J., Zilla P., Fasol R., Deutsch M., Kadletz M.Precoating substrate and surface configuration determine adherence and spreading of seeded endothelial cells on polytetrafluoroethylene grafts . J Vasc Surg1989;9:535-541
13.
Zilla P., Deutsch M., Meinhart J., et al. Clinical in vitro endothelialization of femoralpopliteal bypass grafts: an actuarial follow-up over three years. J Vasc Surg1994;19:540-548
14.
Greisler HP , Cziperle DJ, Kim DU, et al. Enhanced endothelialization of expanded polytetrafluoroethylene grafts by fibroblast growth factor type 1 pretreatment . Surgery1992;112: 224-255
15.
Gray JL, Kang SS, Zenni GC, et al. FGF-1 affixation stimulates EPTFE endothelialization without intimal hyperplasia. Surg Res1994;57:596-612
16.
Clowes AW, Kirkman TR, Reidy MAMechanisms of arterial graft healing: rapid trans-mural capillary ingrowth provides a source of intimal endothelium and smooth muscle in porous PTFE prostheses. Am J Pathol1986;123:220-230
17.
Zarge JI, Huang P., Husak V., et al. Fibrin glue containing fibroblast growth factor type 1 and heparin with autologous endothelial cells reduces intimal hyperplasia in a canine carotid artery balloon injury model. J Vasc Surg1997;25:840-849
18.
Kang S., Grosselin C., Ren D., Greisler HPSelective stimulation of endothelial cell proliferation with inhibition of smooth muscle cell proliferation by FIBRIN GLUEF-1 plus heparin delivered from fibrin glue suspensions. Surgery1995 ;118:280-287
Zarge JI, Husak V., Huang P., Greisler HPFibrin glue containing fibroblast growth factor type 1 and heparin decreases platelet deposition. Am J Surg1997 ;174:188-192
21.
Song SY, Chung JB, Moon YM, Kang JK, Park ISComparison of the hemostatic effect of endoscopic injection with fibrin glue and hypertonic saline-epinephrine for peptic ulcer bleeding: a prospective randomized trial. Endoscopy1997;29:827-833
22.
Moore MM, Freeman MGFibrin glue in breast surgery. J Long Term Effects of Medical Implants1998;8:133-142
23.
Shinohara K. , Kobayashi E., Yoshida T., et al. Effect of fibrin glue on small and large bowel anastomoses in the rat. Eur Surg Res1998;30:8-12
24.
Saitoh S., Nakatsuchi Y.Telescoping and glue technique in vein grafts for arterial defects . Plast Reconstr Surg1995;96:1401-1408
