Venous thromboembolism (VTE) continues to be a major source of morbidity and mortality in the United States with an estimated incidence of greater than 600 000 clinically evident cases each year. It results in more than 200 000 deaths per year and is thought to be the number one cause of preventable in-hospital deaths. This review presents the history, pathophysiology, diagnostic considerations, and treatment options for VTE.
Mannucci PM. Venous thrombosis: the history of knowledge. Pathophysiol Haemost Thromb. 2002;32:209-212. 2. Hunter J. Observations on the inflammation of the internal coats of veins. Trans Soc Improv Med Chir Knowledge. 1793;1:18-25.
White RHThe epidemiology of venous thromboembolism. Circulation. 2003;107(23, suppl 1):14-18.
4.
Anderson FA, Wheeler HB, Goldberg RJA population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT Study . Arch Intern Med. 1991; 151:933-938.
5.
Silverstein MD, Heit JA, Mohr DNTrends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158:585-593.
6.
Kearon C.Natural history of venous thromboembolism. Circulation. 2003;107:122-130.
7.
Clagett P.Prevention of venous thromboembolism. Ann Surg. 1998;208:227-240.
8.
Lensing AW, Levi MM, Buller HRDiagnosis of deep-vein thrombosis using an objective Doppler method. Ann Intern Med. 1990;113:9-13.
9.
The PIOPED Investigators.JAMA. 1990;263:2743-2759.
10.
Schoepf UJ, Costello P.CT angiography for diagnosis of pulmonary embolism: state of the art. Radiology. 2004;230: 329-337.
11.
MacFarlane RGAn enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature. 1964;202:498-99.
Monroe DM, Hoffman M., Roberts HRPlatelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22: 1381-1389.
14.
Adams GL, Manson RJ, Turner I., et al. The balance of thrombosis and hemorrhage in surgery. Hematol Oncol Clin N Am. 2007;21:13-24.
15.
Camerer E., Kolsto A., Prydz H.Cell biology of tissue factor, the principal initiator of blood coagulation . Thromb Res. 1996;81:1-41.
16.
Mann KG, Butenas S., Brummel K.The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol. 2003;23:17-25.
17.
Furie B., Furie B.C. The molecular basis of blood coagulation. Cell. 1988;53:505-518.
18.
Rodgers GM, Greenberg CS, Shuman MACharacterization of the effects of cultured vascular cells on the activation of blood coagulation. Blood. 1983;61: 1155-1162.
19.
Edwards RL, Rickles FR, Bobrove AMMononuclear cell tissue factor: cell of origin and requirements for activation . Blood. 1979;30:311-316.
20.
Drake TA, Morrissey JH, Edgington TSSelective cellular expression of tissue factor in human tissues. Am J Pathol. 1989;134:1087-1097.
21.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA Jr.Interleukin-1 activation of vascular endothelium: effects on procoagulant activity and leukocyte adhesion. Am J Pathol. 1985;121:394-403.
22.
Nawroth PP, Stern DMModulation of endothelial cell hemostatic properties by tumor necrosis factor . J Exp Med. 1986;163:740-745.
23.
Nemerson Y.Tissue factor and hemostasis. Blood. 1988; 71:1-8.
24.
Butenas S., Mann KGKinetics of human factor VII activation. Biochemistry. 1996;46:333-337.
25.
Komiyama Y. , Pedersen AH, Kisiel W.Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor. Biochemistry. 1990;29:9418-9425.
26.
Lawson JH, Mann KGCooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. J Biol Chem.1991;266;11317-11327.
27.
Pieters J., Lindhout T., Hemker HCIn situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. Blood . 1989;74:1021-1024.
28.
Ahmad SS, Rawala-Sheikh R., Walsh PNComponents and assembly of the factor X activating complex. Semin Thromb Hemost. 1992;18:311-323.
29.
Dahlback B., Hildebrand B.Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci U S A. 1994;91:1396-1400.
30.
Jesty J., Lorenz A., Rodriquez J., Wun T.Initiation of the tissue factor pathway of coagulation in the presence of heparin: control by anti-thrombin III and tissue factor pathway inhibitor . Blood. 1996;272:2301-2307.
31.
DiScipio RG, Hermodson MA, Yates SG, Davie EWA comparison of human prothrombin, factor IX, factor X, and protein S. Biochemistry. 1977;16:698-706.
32.
Rijken DC, Sakharov DVBasic principles of thrombolysis: regulatory role of plasminogen. Thromb Res. 2001; 103:S41-S49.
33.
Bates SM, Greer IA, Pabinger I., et al. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133 (6 suppl):844S-886S.
