Restricted accessResearch articleFirst published online 2004-12
Effect of Simvastatin Versus Placebo on Treadmill Exercise Time Until the Onset of Intermittent Claudication in Older Patients With Peripheral Arterial Disease at Six Months and at One Year After Treatment
The authors conducted a study to investigate the effect of simvastatin after 6 months and 1 year on the time to onset of intermittent claudication during treadmill exercise in patients with peripheral arterial disease. Thirty-four patients were randomized to simvastatin, 35 were randomized to placebo. Simvastatin therapy resulted in a 24% increased treadmill exercise time until onset of intermittent claudication from baseline at 6 months and by 42% at 1 year.
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