Sage Journals: Discover world-class research

Abstract

Patients with T2DM have an increased risk of CVD. Prevention of CVD represents the major goal of all treatment of T2DM, and early intervention in those patients at particularly high risk is important.We measured the insulin sensitivity and plasma biomarkers of CVD to determine whether a home-based exercise training program improves biomarker levels and insulin sensitivity. Patients with T2DM (n=12), IGT (n=4) and healthy control subjects (n=9) were studied before and after eight weeks of exercise training by rowing ergometry at 65—70% of peak oxygen uptake. Conclusions: 1) patients with T2DM have elevated plasma concentrations of CVD biomarkers compared to the matched control and IGT groups; 2) a moderate to vigorous intensity home-based training program did not reduce plasma concentrations of these CVD markers; 3) insulin sensitivity improved as a result of exercise training in the control group, but not in the T2DM group.

Keywords

adhesion molecules endothelium exercise training risk factor

References

Boulbou, MS , Koukoulis, GN , Makri, ED , Petinaki, EA , Gourgoulianis, KI , Germenis, AE ( 2005) Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. Int J Cardiol 98(1): 39-44.

Maiorana, A. , O’Driscoll , G. , Cheetham, C. , et al. (2001 ) The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38: 860-6.

Miche, E. , Herrmann, G. , Nowak, M. , et al. (2006) Effect of an exercise training program on endothelial dysfunction in diabetic and non-diabetic patients with severe chronic heart failure. Clin Res Cardiol 95: i117-24.

Tonjes, A. , Scholz, M. , Fasshauer, M. , et al. (2007) Beneficial effects of a 4-week exercise program on plasma concentrations of adhesion molecules. Diabetes Care 30(3): e1.

Hatunic, M. , Finucane, F. , Burns, N. , Gasparro, D. , Nolan, JJ ( 2007) Vascular inflammatory markers in early-onset obese and type 2 diabetes subjects before and after three months’ aerobic exercise training. Diab Vasc Dis Res 4: 231-4.

Bluher, M. , Unger, R. , Rassoul, F. , Richter, V. , Paschke, R. ( 2002) Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes. Diabetologia 45: 210-6.

Gomez, JM , Vila, R. , Catalina, P. , Soler, J. , Badimon, L. , Sahun, M. ( 2008) The markers of inflammation and endothelial dysfunction in correlation with glycated haemoglobin are present in type 2 diabetes mellitus patients but not in their relatives. Glycoconj J 25: 573-9.

Kado, S. Nagata, N. ( 1999) Circulating intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 46: 143-8.

Caballero, AE , Arora, S. , Saouaf, R. , et al. (1999) Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes . Diabetes 48: 1856-62.

10.

Lim, SC , Caballero, AE , Smakowski, P. , LoGerfo, FW , Horton, ES , Veves, A. (1999) Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes Care 22: 1865-70.

11.

el-Mesallamy, H. , Suwailem, S. , Hamdy, N. (2007) Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients. Mediators Inflamm 2007: 73635.

12.

Natali, A. , Toschi, E. , Baldeweg, S. , et al. (2006) Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. Diabetes 55: 1133-40.

13.

Rudy, A. , Kowalska, I. , Straczkowski, M. , Kinalska, I. ( 2005) Homocysteine concentrations and vascular complications in patients with type 2 diabetes. Diabetes Metab 31: 112-7.

14.

Oberbach, A. , Tonjes, A. , Kloting, N. , et al. (2006) Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 154:577-85.

Cardiovascular disease markers in type 2 diabetes: the effects of a moderate home-based exercise training programme

Abstract

Keywords

References