Over the past 20 years there has been a massive worldwide investment in genetic research. Many claims have been made about the power of genetic knowledge to transform the practice of medicine. This aim of this symposium was to explore the role of genetic knowledge in the medical management at the present time and to anticipate future advances in treatment.
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References
1.
FatkinDCMacRaeSasakiT Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med 1999; 341:1715–24.
2.
Sen-ChowdhrySPSyrrisMcKennaWJ.Genetics of right ventricular cardiomyopathy. J Cardiovasc Electrophysiol 2005; 16:927–35.
3.
PearsonERBJStarkeyPowellRJ Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet 2003; 362:1275–81.
4.
GloynALERPearson,Antcliff JF Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004; 350:1838–49. Erratum in: N Engl J Med 2004; 351:1470.
5.
RibicCMDJSargentMooreMJ Tumor microsatelliteinstability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003; 349:247–57.
6.
YoungJMABarkerSimmsLA Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. Clin Gastroenterol Hepatol 2005; 3:254–63.
7.
Meijers-HeijboerHvan den OuwelandAKlijnJ Lowpenetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 2002; 31:55–9.
