Restricted accessResearch articleFirst published online 2010-9
Assessment of Mean Platelet Volume of Pregnant Women with Gestational Diabetes Mellitus and Impaired Glucose Tolerance as a Marker of Future Cardiovascular Disease Risk
Objective To assess the platelet count and mean platelet volume (MPV) of pregnant women with gestational diabetes mellitus (GDM) or gestational impaired glucose tolerance (GIGT) to find out whether GDM and GIGT are risk factors for future development of cardiovascular disease. Study design A 50-g oral glucose load (OGL) was administered to all participants and heamotologic parameters were studied at 24–28 gestational weeks. When plasma glucose ≥ 140 mg/dl (7.8 mmol/L) was measured following the OGL, a 100 g-3-h oral glucose tolerance test was undertaken. Results A significant difference was observed for MPV values between the GDM and normal OGL groups.
Conclusion Presence of a high MPV in GDM could demonstrate an increase in the risk for current and future thrombotic complications.
HannaFWPetersJR. Screening for gestational diabetes: past, present and future. Diabet Med2002;19:351–58.
2.
American Diabetes Association. Gestational diabetes mellitus. Diabetes Care2003;27:88–90.
3.
BockGManDalla CCampioniMPathogenesis of pre-diabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance. Diabetes2006;55:3536–49.
4.
MoleonJimenez JJCavanillasBueno ADel CastilloLuna JDPrevalence of gestational diabetes mellitus: Variations related to screening strategy used. Eur J Endocrinol2002;146:831–7.
5.
EvansMJ. Diabetes and pregnancy: a review of pathology. Br J Diabetes Vasc Dis2009;9:201–6.
GabbeSGGravesCR. Management of diabetes mellitus complicating pregnancy. Obstet Gynecol2003;102:857–68.
8.
KhawKTWarehamNBinghamSAssociation of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med2004;141:413–20.
9.
DaviglusMLStamlerJPirzadaAFavorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA2004;292:1588–92.
10.
KhandekarMMKhuranaASDeshmukhSDPlatelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol2006;59:146–9.
11.
CamurKiliçli NDemirtunçRKonuralpCCould mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit2005;11:387–92.
12.
ChuSGBeckerRCBergerPBMean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost2010;8:148–56.
13.
NadarSKLipGYBlannAD. Platelet morphology, soluble P selectin and platelet P selectin in acute ischaemic stroke. The West Birmingham Stroke Project. Thromb Haemost2004;92:1342–8.
14.
McCabeDJHarrisonPSidhuPSCirculating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack. Br J Haematol2004;126:861–9.
15.
O'MalleyTLanghornePEltonRAStewartC.Platelet size in stroke patients. Stroke1995;26:995–9.
16.
SharpePCTrinickT.Mean platelet volume in diabetes mellitus. Q J Med1993;6:739–42.
17.
KhuwajaAKRafiqueGWhiteFAzamSI. Macrovascular complications and their associated factors among persons with type 2 diabetes in Karachi, Pakistan: a multi-center study. J Pak Med Assoc2004;54:60–6.
18.
National Diabetes Data Group.Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes1979; 28:1039–57.
19.
MetzgerBEChoNHRostonSMRadvanyR.Pre-pregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus. Diabetes Care1993;16:1598–605.
KimCNewtonKMKnoppRH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care2002;25:1862–8.
22.
LeeAJHiscockRJWeinPGestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes. Diabetes Care2007;30:878–83.
23.
LöbnerKKnopffABaumgartenAPredictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes2006;55:792–7.
24.
LauenborgJHansenTJensenDMIncreasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population. Diabetes Care2004;27:1194–9.
25.
WeijersRNBekedamDJ. Relationship between gestational diabetes mellitus and type 2 diabetes: evidence of mitochondrial dysfunction. Clin Chem2007;53:377–83.
26.
CarrDBNewtonKMUtzschneiderKMModestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus. Diabetes Care2008;31:1037–9.
27.
VambergueADogninCBoulogneAIncreasing incidence of abnormal glucose tolerance in women with prior abnormal glucose tolerance during pregnancy: DIAGEST 2 study. Diabet Med2008;25:58–64.
28.
KoustaELawrenceNJGodslandIFInsulin resistance and β-cell dysfunction in normoglycaemic European women with a history of gestational diabetes. Clin Endocrinol2003;59:289–97.
29.
AnastasiouELekakisJPAlevizakiMImpaired endothelium-dependent vasodilatation in women with previous gestational diabetes. Diabetes Care1998;21:2111–5.
30.
WeberTAuerJO'RourkeMFArterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation2004;109:184–9.
31.
HuJNormanMWallensteenMGennserG.Increased large arterial stiffness and impaired acetylcholine induced skin vasodilatation in women with previous gestational diabetes mellitus. Br J Obstet Gynaecol1998;105:1279–87.
32.
SaldeenPOlofssonPLauriniRN. Structural, functional and circulatory placental changes associated with impaired glucose metabolism. Eur J Obstet Gynecol Reprod Biol2002;105:136–42.
33.
AlonsoASotoIUrgellesMFAcquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol2002;187:1337–42.
34.
JakubowskiJAThompsonCBVaillancourtRArachidonic acid metabolism by platelets of differing size. Br J Haematol1983;53: 503–11.
35.
ChamberlainKGTongMChiuEPeningtonDG. The relationship of human platelet density to platelet age: platelet population labeling by monoamine oxidase inhibition. Blood1989;73:1218–25.
36.
PereiraJCretneyCAsterRH. Variation of class I HLA antigen expression among platelet density cohorts: a possible index of platelet age? Blood1988;71:516–9.
37.
MartinJ.The relationship between megakaryocyte ploidy and platelet volume. Blood Cells1989;15:108–21.
38.
TavilYSenNYaziciHUMean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res2007;120:245–50.
39.
BoosCJLipGY. Assessment of mean platelet volume in coronary artery disease: what does it mean? Thromb Res2007;120:11–3.
40.
YinSMLiYQXieSFStudy on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus. Zhongua Fu Chan Ke Za Zhi2005;40:25–8.
41.
BozkurtNYilmazEBiriAThe mean platelet volume in gestational diabetes. J Thromb Thrombolysis2006;22:51–4.
42.
SaigoKYasunagaMRyoR.Mean platelet volume in diabetics. Rinsha Byar1992;40:215–7.
43.
De Pablos VelascoPLMarinMartinez FJPerezRodriguez FPrevalence and determinants of diabetes mellitus and glucose intolerance in a Canarian Caucasian population: comparison of the 1997 ADA and the 1995 WHO criteria: the Guia study. Diabet Med2001;18:235–41.
