Trial Protocol and Sample Result of a Study Comparing the ClearPlan Easy™ Fertility Monitor with Serum Hormone and Vaginal Ultrasound Measurements in the Determination of Ovulation
Free accessResearch articleFirst published online February, 2001
Trial Protocol and Sample Result of a Study Comparing the ClearPlan Easy™ Fertility Monitor with Serum Hormone and Vaginal Ultrasound Measurements in the Determination of Ovulation
This paper presents a preliminary result from a study designed to evaluate the ability of the ClearPlan Easy™ Fertility Monitor* to predict ovulation, compared with conventional methods of ovulation determination, i.e. serum hormone measurements (estradiol and luteinizing hormone) and vaginal ultrasound scans (follicle size and endometrium thickness). Fifty-five female volunteers will be monitored over 3 consecutive monthly cycles. Preliminary data gathered from one volunteer are included in this presentation. These data indicate that the ClearPlan Easy™ Fertility Monitor predicted ovulation as accurately as serum hormone measurements and vaginal ultrasound scans. The results show that this monitor has potential as a home-based ovulation predictor for couples attempting to conceive.
MartinezARZinamanMJJenningsVHLamprechtVM: Prediction and detection of the fertile period: the markers. Int J Fertil1995; 40: 139–155
2.
KerinJFEdmondsDKWarnesGMCoxLWSeamarkRFMathewsCD: Morphological and functional relations of Graafian follicle growth to ovulation in women using ultrasonic, laparoscopic and biochemical measurements. Br J Obstet Gynaecol1981; 88: 81–90
3.
MoghissiKSSynerFNEvansTN: A composite picture of the menstrual cycle. Am J Obstet Gynaecol1972; 114: 405–418
4.
World Health Organization (WHO) Task Force on Methods for Determination of the Fertile Period: Temporal relationships between ovulation and defined changes in the concentration of the plasma estradiol-17β, luteinizing hormone, follicle stimulating hormone and progesterone. II. Histologic dating. Am J Obstet Gynecol1981; 139: 886–895
5.
BurgerHG: Estradiol: the physiological basis of the fertile period. Int J Gynaecol Obstet1989; 1 (Suppl): 5–9
6.
PauersteinCJEddyCACroxattoHDHessRSiler-KhodrTMCroxattoHB: Temporal relationships of estrogen, progesterone and luteinizing hormone levels to ovulation in women and infra-human primates. Am J Obstet Gynaecol1978; 130: 876–886
7.
SpielerJMCollinsWP: Potential fertility — defining the window of opportunity. J Int Med Res2001; 29 (Suppl 1): 3A–13A
8.
BranchCMCollinsPOCollinsWP: Ovulation prediction: changes in the concentrations of urinary estrone-3-glucuronide, estradiol-17-β-glucuronide and estriol-16-α-glucuronide during conceptional cycles. J Steroid Biochem1982; 16: 345–347
9.
CatalanRCastellanosJMPalominoTSentiMAntolinMGalardRM: Correlation between plasma estradiol and estrone-3-glucuronide in urine during the monitoring of ovulation induction therapy. Int J Fertil1989; 34: 271–275
10.
CollinsWPBranchCMCollinsPO: Ovulation prediction and detection by the measurement of steroid glucuronides. In: Research on Fertility and Sterility (Cortes-PrietoJda PazA CampasNeves-e-CastroM, eds). Lancaster: MTP Press Ltd, 1981; p19
11.
AdekunleAOCollinsWPWhiteheadMI: Correlation of ovarian follicle size and the urinary excretion of oestrone glucuronide, luteinising hormone and pregnanediol-3-glucuronide in spontaneous cycles. Afr J Med Sci1988; 17: 77
12.
SchiphorstLEMCollinsWPRoystonJP: An estrogen test to determine the times of potential fertility in women. Fertil Steril1985; 44: 328–334
13.
World Health Organization: Temporal relationships between indices of the fertile period. Fertil Steril1983; 39: 647–655
14.
BourneTHHagströmH-GGranbergSJosefssonBHahlinMHellbergP: Ultrasound studies of vascular and morphological changes in the human uterus after a positive self-test for the urinary luteinising hormone surge. Hum Reprod1996; 11: 369–375
15.
BourneTHHagströmH-GHahlinMJosefssonBGranbergSHellbergP: Ultrasound studies of vascular and morphological changes in the human corpus luteum during the menstrual cycle. Fertil Steril199665: 753–758
16.
RoystonJP: Basal body temperature, ovulation and the risk of conception, with special reference to the lifetimes of sperm and egg. Biometrics198238: 397–406
17.
MayK: The Unipath personal contraceptive system. In: Natural Contraception Through Personal Hormone Monitoring (BonnarJ, ed). New York: The Parthenon Publishing Group, 1996; pp35–44
18.
RoetzerJ: Erveiterte Basaltemperaturmessung und Empfangnisregelung. Archiv fur Gynakologie1969; 206: 195
19.
The sympto-thermal method: ten years of change. Linacre Quarterly1978; 45: 368
20.
BehreHMKuhlageJGaßnerCSonntagBSchemCSchneiderHPG: Prediction of ovulation by urinary hormone measurements with the home use ClearPlan Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements. Hum Rep2000; 12: 2478–2482
