The real economy has been seriously hit in recent years, and the government has introduced relevant economic policies to stabilize and promote the development of the real economy. However, the policy uncertainty negatively affects the development of manufacturing enterprises, and the relevant influencing factors need to be analyzed for manufacturing enterprises to achieve long-term stable development. In this study, regression analysis is used to investigate manufacturing enterprises’ technological innovation’ and economic policy uncertainty (EPU)’s connection. Manufacturing enterprises’ innovation activities are negative correlated with EPU and leads to a sustainable lack of technological innovation in enterprises in the results. Meanwhile, in terms of R&D investment and invention patents, EPU has a greater degree of influence on technological innovation of non-state manufacturing enterprises. The proposed methods and viewpoints can provide a scientific research method for measuring the quality of enterprise innovation, that is, using the knowledge breadth method to test the quality of enterprise patents, effectively avoiding the drawbacks of using the number of patents to measure the quality of enterprise innovation.
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