Introduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients.
Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction.
Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was χ2 = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14.
Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.
Braunwald E (ed.). Heart Disease: A textbook of Cardiovascular Medicine. Philadelphia : W.B. Saunders, 1997.
2.
Ambrosioni E. , Bacchelli S., Degli Esposti D. et al. ACE inhibitors and atherosclerosis . Eur J Epidemiol1992 ;8:129-33.
3.
Kurtz TWThe ACE of hearts. Nature1992; 359:588-9.
4.
Singer DRJ , Missouris CG, Jeffery S.Angiotensin converting enzyme gene polymorphism. What to do about all the confusion?Circulation1996;94:236-9.
5.
Kim S., Iwao H.Molecular and cellular mechanisms of angiotensinII-mediated cardiovascular and renal diseases. Pharmacol Rev2000;52:11-34.
6.
Ranjith N., Pegoraro RJ, Rom L., Lanning PA, Naidoo DPRenin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians. Cardiovasc J S Afr2004;15(1):22-6.
Warnholtz A. , Nickenig G., Schulz E. et al. Increased NADH-oxidase mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation1999; 99:2027-33.
9.
De Gasparo M. , Catt KJ, Inagami T., Wright JW, Unger T.International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev2000;52:415-72.
10.
Timmermans PB , Wong PC, Chiu AT et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev1993 ;45:205-51.
11.
Bonnardeaux A. , Davies E., Jeunemaitre X. et al. Angiotensin II type 1 receptor gene polymorphism in human essential hypertension. Hypertension1994;24:63-9.
12.
Lin SY, Goodfriend TLAngiotensin receptors. Am J Physiol1970;218:1319-28.
13.
Ishigam T., Umemura S., Iwamoto T. et al. Molecular variant of angiotensinogen gene is associated with coronary atherosclerosis. Circulation1995;91:951-4.
14.
Messias A., Bruno Soares M., Clauber L. et al. The A1166C polymorphism of the angiotensin II type 1 receptor in acute myocardial infarction. Arq Bras Cardiol2004;83:404-08.
15.
Monika B., Zbingniew P., Danuta S. et al. Renin-angiotensin system gene polymorphism: assessment of the risk of coronary heart disease. Kardiol Pol2003 ;58:1-9.
16.
Berge KE, Bakken A., Bohn M., Erikssen J., Berg KADNA polymorphism at angiotensin II type 1 receptor locus and myocardial infarction . Clin Genet1997; 52:71-6.
17.
Lahiri DK, Bye S., Nurnberger JI Jr, Hodes ME, Crisp M.A non-organic and non-enzymatic extraction method gives high yields of genomic DNA from whole-blood samples than do nine other methods tested . J Biochem Biophys Methods1992;25:193-205.
18.
Badenhop RF , Wang XL, Wilcken DEAngiotensin-converting enzyme genotype in children and coronary events in their grandparents. Circulation1995;91:1655-8.
19.
Eichner JE, Christiansen VJ, Moore WE et al. Angiotensin converting enzyme gene polymorphism in a cohort of coronary angiography patients. Atherosclerosis2001;54:673-9.
20.
Guo D., Yulin S., Pavel H., Tadashi I.The angiotensin II type I receptor and receptor associated proteins . Cell Res2001;11:165-80.
21.
Ross R.Atherosclerosis: an inflammatory disease. N Engl J Med1999;340:115-26.
22.
Kishida M., Otsuka F., Ogura T. et al. Chronic treatment with amlodipine modulates adrenocortical angiotensin II receptor in spontaneously hypertensive rats. Life Sci2001;69:113-22.
23.
Jiang ZN, Zhao WS, Yu F. et al. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Chin Med J2001 ;114:1249-51.
24.
Tanaka Y., Tamura K., Koide Y. et al. The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP down regulates AT1R and ameliorates cardiomyocyte hypertrophy. FEBS Lett2005;579:1579-86.
25.
Yu J., Prado GN, Taylor L., Pal-Ghosh R., Polgar P.Hybrid formation between the intracellular faces of the bradykinin B2 and angiotensin II AT1 receptors and signal transduction. Int Immunopharmacol2002;2:1807-22.
26.
Mizuno T., Makino M., Fujiwara Y. et al. Renin-angiotensin system gene polymorphism in Japanese stroke patients . Int Congr Ser2003;1252:83-90.
27.
Jones A., Dhamrait SS, Payne JR et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension2003;42:500-06.
28.
Yan C., Zhan J., Feng W.Gene polymorphisms of angiotensin II type 1 receptor and angiotensin-converting enzyme in two ethnic groups living in Zhejing Province, China. J Renin Angiotensin Aldosterone Syst2005;6:132-7.
29.
Tiret L., Bonnadeaux A., Poirier O. et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type receptor gene polymorphism on risk of myocardial infarction. Lancet1994;344:910-13.
30.
Mehmet SU, Onder O., Mehmet Y. et al. Association between A/C 1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions of patients with acute myocardial infarction. Circ J2006;70:1275-9.
31.
Jones A., Dhamrait SS, Payne JR et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension2003;42:500-06.
32.
Gardemann A. , Fink M., Stricker J. et al. ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals. Atherosclerosis1998;139:153-9.
33.
Ashavaid TF , Shalia KK, Nair KG, Dalal JJACE and AT1R gene polymorphisms and hypertension in Indian population. J Clin Lab Anal2000 ;14:230-7.
34.
Prasad P, Tiwari AK, Kumar KM et al. Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. BMC Med Genet 2006;7:42-50. 35. Nigam PK, Narain VS, Hasan M. Serum lipid profiles in patients with acute myocardial infarction. Indian J Clin Biochem 2004;19(1):67-70.
