This study aims to learn from past global health crises, encouraging industry leaders worldwide to take proactive steps in implementing extra health and safety measures for future potential crises. The research employs a quantitative approach to investigate a proposed model suggesting that hotel employees’ adherence to health and safety regulations is contingent on the availability of supportive organizational resources. An electronic questionnaire was administered to hotel employees in Egypt, resulting in 213 valid responses. The data was analyzed using SPSS 25 and AMOS 24. The findings indicate a strong connection between health and safety training, health and safety resources, and health and safety compliance. Additionally, the results reveal direct and significant links between health and safety compliance, stress reduction, improved employee resilience, and enhanced task performance. Moreover, significant indirect effects were found between health and safety training, health and safety resources, and healthy organizational outcomes, with health and safety compliance serving as a mediator. The current study provides a valuable theoretical and practical contribution on employee motivation to comply with health standards, employee-organization interactions, resilience, and crisis management to better prepare for future health crises.
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