Since 1876, developments in nutritional science have followed those in chemistry, physiology, biochem istry and medicine. The essential relationship between food and body energy has been elucidated. The aetiology of diseases long known in human his tory has been traced to deficiencies of specific nutri ents, the 'vitamins', required in very small amounts. These substances have been isolated, identified and synthesised. Research in infant malnutrition has led to the recognition that comparatively small changes in biochemical programming during growth and development may cause disease later in life. Dietary 'roughage' has been found to have significance in dis ease prevention and prospects for the very sick have been improved by the development of alternative feeds. Knowledge of the human genome promises exciting new advances for nutrition in relation to public health and clinical medicine.
Anderson T.W., Suranyi G. and Beaton G. (1974). The effect on winter illness of large doses of vitamin C. Can Med Assoc J; 111, 31-42
2.
Ashwell M. (1993). McCance and Widdowson- A Scientific Partnership of 60 Years. London: British Nutrition Foundation
3.
Banga I., Ochoa S. and Peters R.A. (1939). Pyruvate oxidation in brain. VI. The active form of vitamin B1 and the role of C4 dicarboxylic acid. Biochem J; 33,1109-1121
4.
Barker D J P (1998). Mothers, Babies and Health in Later Life. London: Churchill Livingstone
5.
Bynum W.F. (1994). Science and the Practice of Medicine in the Nineteenth Century. Cambridge: Cambridge University Press
6.
Chick H., Macrae T.F., Martin A J P and Martin C.J. (1938). 111 Curative action of nicotine acid on pigs suffering from the effects of a diet consisting largely of maize. Biochem J; 32, 10-12
7.
Coursin D.B. (1954). Convulsive seizures in infants with pyridoxine deficient diet. JAMA; 154, 406-408
8.
Creagan E.T., Moertel C.G., O'Fallon R.J., Schutt A.J., O'Connell M.J., Rubin J., et al (1979). Failure of high dose vitamin C to benefit patients with advanced cancer. N Engl J Med; 301, 687-690
9.
Cuthbertson D.P. (1932). Observations on the disturbance of metabolism produced by injury to the limbs. QJM; 25, 233-246
10.
Dam K. ( 1935). The antihaemorrhagic factor of the chick. Biochem J; 29, 1273-1285
11.
Davidson L S P and Girdwood R.H. (1947). Folic acid as a therapeutic agent. BMJ; 1, 587-591
12.
Deluca H.F. (1982). Metabolism and molecular mechanism of action of vitamin D. Trans Biochem Soc; 10,147-158
13.
Dicke W.K. (1950). Coeliac Disease: Investigation of Harmful Effects of Certain Types of Cereal on Patients. Doctoral thesis, University of Utrecht
14.
Dickerson J W T (1986a). Food intolerance: fact or fallacy?Nursing; 3(8), 276-280
15.
Dickerson J W T (1986b). Hospital induced malnutrition: a cause for concern . The Professional Nurse; August, 293-296
16.
Dickerson J W T (1995). Nutrition, Brain Growth and Development. In: Essays on Auxology, pp. 444-445. (Edited by R Hauspie, G Lindgren and F Falkner). Welwyn Garden City: Castlemead Publications
17.
Dickerson J W T and Williams C.M. (1990). Vitamin-Related Disorders. In: The Metabolic and Molecular Basis of Acquired Disease, pp. 634-669. (Edited by R D Cohen, B Lewis, K G M M Alberti and A M Denman). London: Bailliere Tindall
18.
Drummond J.C. (1920). The nomenclature of the so-called accessory food factors (vitamins). Biochem J; 14, 660
19.
Evans H.M. and Bishop K.S. (1923). Existence of a hitherto unknown dietary factor essential for reproduction. JAMA; 81, 889-892
20.
Food Standards Committee (1974). Second Report on Bread and Flour. London: HM Stationery Office
21.
Ginter E. (1973). Cholesterol: vitamin C controls its transformation to bile acids. Science NY; 179, 702-707
22.
Golden M H N (1988). Marasmus and Kwashiorkor. In: Nutrition in the Clinical Management of Disease, pp. 88-109. Second Edition. (Edited by J W T Dickerson and H A Lee). London: Arnold
23.
Gyorgy P. (1971). Developments leading to the metabolic role of vitamin B6. Am J Clin Nutr; 24, 1250-1256
24.
Hill G.L., Blackett R.L., Pickford I., Burkinshaw L., Young G.A., Warren J.V., et al (1977). Malnutrition in surgical patients - an unrecognised problem. Lancet; 1, 689-692
25.
Holst A. and Froelich T. (1907). Experimental studies relating to ship beri-beri and scurvy. J Hyg (Lond); 7, 634-671
26.
Horsey J., Livesley B. and Dickerson J W T (1981). Ischaemic heart disease and aged patients: effect of ascorbic acid on lipoproteins. J Hum Nutr, 35, 53-58
27.
Howe G.M. (1972). Man, Environment and Disease in Britain. Hormondsworth: Penguin Books
28.
Kodicek E. (1974). The story of vitamin D from vitamin to hormone . Lancet; 1, 325-329
29.
Lee H.A. (1974). Historical Review of Parenteral Nutrition. In: Parenteral Nutrition in Acute Metabolic Illness, pp. 3-10. (Edited by H A Lee). London: Academic Press
30.
Loomis W.F. (1967). Skin pigment regulation of vitamin D synthesis in man. Science NY; 157, 501-506
31.
Mackarness R. (1976). Not All in the Mind. London : Pan Books
32.
Mccance R.A. and Widdowson E.M. (1942). Mineral metabolism of healthy adults on white and brown bread dietaries. J Physiol; 101, 44
33.
Mccollum E.V. (1957). A History of Nutrition. Boston, Massachusetts: Houghton Mifflin
34.
Mclaren D.S. (1974). The great protein fiasco. Lancet; 11, 93-96
35.
Mellanby E. (1950). A History of Nutrition. Baltimore : Williams and Wilkins
36.
Mitchell H.K., Snell E.E. and Williams R.J. (1941). The concentration of folic acid. J Am Chem Soc; 63, 2284
37.
Morse E., Rivers J. and Heughan A. (1988). The Family Guide to Food and Health. London: Berrie and Jenkins
38.
Mrc (Medical Research Council) (1953). Vitamin C Requirement of Human Adults.
39.
Report of the Vitamin C Sub-Committee of the Accessory Food Factors Committee. Special Report, Number 280. London : HM Stationery Office
40.
Needham J. and Baldwin E. (1949). Hopkins and Biochemistry 1861-1947. Cambridge: Heffer
41.
Older M W J, Edwards D. and Dickerson J W T (1980). A nutrient survey in elderly women with femoral fracture. BrJ Surg; 67, 884-886
42.
Painter N.S. and Burkitt D.P. (1971). Diverticular disease of the colon: a deficiency disease of Western civilisation. BMJ; 2, 450
43.
Poulter J.M., White W.F. and Dickerson J W T (1984). Ascorbic acid supplementation and five year survival rates in women with early breast cancer. Acta Vitaminol Enzymol; 6(3), 175-182
44.
Rickes E.L., Brink N.G., Koniuszy F.R., et al (1948). Crystalline vitamin B12. Science NY; 107, 396-397
45.
Schorah C.J. and Smithells R.W. (1991). Maternal vitamin nutrition and malformations of the neural tube. Nutr Res Revs; 4, 33-49
46.
Sharman I.M. (1974). Vitamin C: Historical Aspects. In: Vitamin C, p. 1. (Edited by G G Birch and K Parker). London: Applied Science Publishers
47.
Smith E.L. and Parke L F J (1948). Purification of the anti pernicious factor. Biochem J; 43, V111
48.
Szent-Gyorgi A. (1928). Observations on the function of peroxidase systems and the chemistry of the adrenal cortex: description of a new carbohydrate derivative. Biochem J; 22, 1387-1409
49.
Waugh W.A. and King C.G. (1932). Isolation and identification of vitamin C. J Biol Chem; 9, 325-331
50.
Who (World Health Organization) (1992). Prevention of Childhood Blindness. Geneva : World Health Organization
51.
Widdowson E.M. (1955). Assessment of the energy value of human foods . Proc Nutr Soc; 14, 142-154
52.
Williams C.D. (1935). Kwashiorkor: a nutritional disease of children associated with a maize diet. Lancet; 11,1151-1152
53.
Wills L. (1931). Treatment of 'pernicious anaemia of pregnancy' and 'tropical anaemia' with special reference to yeast extract as a curative agent. BMJ; 1, 1059-1064
